Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A8F1F2 (GCH1_RICM5) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:RMA_0545
OrganismRickettsia massiliae (strain Mtu5) [Complete proteome] [HAMAP]
Taxonomic identifier416276 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000058676

Sites

Metal binding791Zinc By similarity
Metal binding821Zinc By similarity
Metal binding1501Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A8F1F2 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 26CE21BEDD4C0F45

FASTA18921,555
        10         20         30         40         50         60 
MSKPTREEAK EAVRTLLKFI GEDPSREGLL KTPDRVINSY AEIFSGYGKD VAKILNTKFY 

        70         80         90        100        110        120 
ETCNFQDFIL LNIKFTSFCE HHILPFNGTV DIAYVPDNCI VGISKLARIV NIFARRLQIQ 

       130        140        150        160        170        180 
EKMTVQIAES VQENLKPLGV AVKISAVHSC MSMRGVMQDN SVMNTMHYTG IFAEQQKYRH 


EFLNLTAKR 

« Hide

References

[1]"Lateral gene transfer between obligate intracellular bacteria: evidence from the Rickettsia massiliae genome."
Blanc G., Ogata H., Robert C., Audic S., Claverie J.-M., Raoult D.
Genome Res. 17:1657-1664(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Mtu5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000683 Genomic DNA. Translation: ABV84738.1.
RefSeqYP_001499285.1. NC_009900.1.

3D structure databases

ProteinModelPortalA8F1F2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING416276.RMA_0545.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV84738; ABV84738; RMA_0545.
GeneID5665257.
KEGGrms:RMA_0545.
PATRIC17895382. VBIRicMas83254_0674.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAVIVVTEC.
OrthoDBEOG6XHC8G.
ProtClustDBPRK09347.

Enzyme and pathway databases

BioCycRMAS416276:GJD3-553-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_RICM5
AccessionPrimary (citable) accession number: A8F1F2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways