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A8F0M4

- RUVC_RICM5

UniProt

A8F0M4 - RUVC_RICM5

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Protein
Crossover junction endodeoxyribonuclease RuvC
Gene
ruvC, RMA_0166
Organism
Rickettsia massiliae (strain Mtu5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71Magnesium By similarity
Metal bindingi67 – 671Magnesium By similarity
Metal bindingi140 – 1401Magnesium By similarity
Metal bindingi143 – 1431Magnesium By similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciRMAS416276:GJD3-170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:RMA_0166
OrganismiRickettsia massiliae (strain Mtu5)
Taxonomic identifieri416276 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000001311: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Crossover junction endodeoxyribonuclease RuvCUniRule annotation
PRO_0000332437Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416276.RMA_0166.

Structurei

3D structure databases

ProteinModelPortaliA8F0M4.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.

Phylogenomic databases

eggNOGiCOG0817.
HOGENOMiHOG000012181.
KOiK01159.
OrthoDBiEOG6RG044.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.
PROSITEiPS01321. RUVC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8F0M4-1 [UniParc]FASTAAdd to Basket

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MIILGIDPAL GSLGWAVVAK ETAQLKYLAS GIIKTNSKDA IHHRLAFINS    50
TLEKVILEYQ PNMAAIEETF VNTNSVTSLK LGYARGAIMS LIGRYNLDMR 100
EFKPNTVKKT VTGYGHAEKD QILHMIKLLL PGTFLITNSD EADAVAIAYT 150
CLVTKNY 157
Length:157
Mass (Da):17,274
Last modified:April 29, 2008 - v2
Checksum:iDE9428D09C8D10F8
GO

Sequence cautioni

The sequence ABV84460.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000683 Genomic DNA. Translation: ABV84460.1. Different initiation.
RefSeqiYP_001499007.1. NC_009900.1.

Genome annotation databases

EnsemblBacteriaiABV84460; ABV84460; RMA_0166.
GeneIDi5664995.
KEGGirms:RMA_0166.
PATRICi17894454. VBIRicMas83254_0220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000683 Genomic DNA. Translation: ABV84460.1 . Different initiation.
RefSeqi YP_001499007.1. NC_009900.1.

3D structure databases

ProteinModelPortali A8F0M4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416276.RMA_0166.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV84460 ; ABV84460 ; RMA_0166 .
GeneIDi 5664995.
KEGGi rms:RMA_0166.
PATRICi 17894454. VBIRicMas83254_0220.

Phylogenomic databases

eggNOGi COG0817.
HOGENOMi HOG000012181.
KOi K01159.
OrthoDBi EOG6RG044.

Enzyme and pathway databases

BioCyci RMAS416276:GJD3-170-MONOMER.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00228. ruvC. 1 hit.
PROSITEi PS01321. RUVC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Lateral gene transfer between obligate intracellular bacteria: evidence from the Rickettsia massiliae genome."
    Blanc G., Ogata H., Robert C., Audic S., Claverie J.-M., Raoult D.
    Genome Res. 17:1657-1664(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mtu5.

Entry informationi

Entry nameiRUVC_RICM5
AccessioniPrimary (citable) accession number: A8F0M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 40 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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