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Protein

Ribonuclease 3

Gene

rnc

Organism
Rickettsia massiliae (strain Mtu5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46MagnesiumUniRule annotation1
Active sitei50UniRule annotation1
Metal bindingi119MagnesiumUniRule annotation1
Active sitei122UniRule annotation1
Metal bindingi122MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:RMA_0164
OrganismiRickettsia massiliae (strain Mtu5)
Taxonomic identifieri416276 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000001311 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000758031 – 227Ribonuclease 3Add BLAST227

Proteomic databases

PRIDEiA8F0M2

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA8F0M2
SMRiA8F0M2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 133RNase IIIUniRule annotationAdd BLAST130
Domaini158 – 226DRBMUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246808
KOiK03685
OMAiLTHKSCK

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

A8F0M2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESFETLEKL LSYSFKNKEL LIEALSHPSL RQHHEYKDDK DYERLEFLGD
60 70 80 90 100
AVLNLVITEI LFRNFANYNE GHLAKIRSYL VCKETICMVG AKLTLKNYII
110 120 130 140 150
MTHGEEVAGG RDNLNNIENA TEALIAAIYL DSNIETTYDI IEKLWAEFIK
160 170 180 190 200
VQNLTDYDPK TALQEWAQAS DHHLPIYRLI KREGASHSST FTVLVKVKDY
210 220
EQTGTGHAIK EAEKNAARSL LHRLKND
Length:227
Mass (Da):26,089
Last modified:November 13, 2007 - v1
Checksum:iD676C2E05063FF78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000683 Genomic DNA Translation: ABV84458.1
RefSeqiWP_012152436.1, NC_009900.1

Genome annotation databases

EnsemblBacteriaiABV84458; ABV84458; RMA_0164
KEGGirms:RMA_0164

Similar proteinsi

Entry informationi

Entry nameiRNC_RICM5
AccessioniPrimary (citable) accession number: A8F0M2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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