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A8EZ58

- MDH_RICCK

UniProt

A8EZ58 - MDH_RICCK

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Protein
Malate dehydrogenase
Gene
mdh, A1E_03540
Organism
Rickettsia canadensis (strain McKiel)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351NAD By similarity
Binding sitei84 – 841Substrate By similarity
Binding sitei90 – 901Substrate By similarity
Binding sitei97 – 971NAD By similarity
Binding sitei122 – 1221Substrate By similarity
Binding sitei153 – 1531Substrate By similarity
Active sitei177 – 1771Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NAD By similarity
Nucleotide bindingi120 – 1223NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRCAN293613:GHI3-710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:A1E_03540
OrganismiRickettsia canadensis (strain McKiel)
Taxonomic identifieri293613 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000007056: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Malate dehydrogenaseUniRule annotation
PRO_1000026490Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi293613.A1E_03540.

Structurei

3D structure databases

ProteinModelPortaliA8EZ58.
SMRiA8EZ58. Positions 1-314.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYAPSAFV.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A8EZ58-1 [UniParc]FASTAAdd to Basket

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MKKNPKISLI GSGNIGGTLA HLISIKELGD IVLFDVAEGV PQGKALDLMQ    50
AGTMLGSDIK IKGSNNYKDI EGSDAIIITA GLPRKPGMSR DDLISVNTKI 100
MKDVAQNIKK YAPSAFVIVI TNPLDVMVYV ILKESGLPHN KVIGMAGVLD 150
SSRFNLFLAE EFKVSVNSVN SIVLGGHGEA MVPLARYSTV SGIPIPDLIK 200
MGLSSNENIE KIIDRTRNGG GEIVALLKTG SAYYAPATSA IEMLESYLKD 250
KRQILTCAAY LQGEYGIHDL YVGVPIIIGT EGVLNVIELQ LTKEEKALFD 300
KSVEGVRKLI EMVK 314
Length:314
Mass (Da):33,786
Last modified:November 13, 2007 - v1
Checksum:i6E9B6E5939D8B890
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000409 Genomic DNA. Translation: ABV73641.1.
RefSeqiYP_001492426.1. NC_009879.1.

Genome annotation databases

EnsemblBacteriaiABV73641; ABV73641; A1E_03540.
GeneIDi5625980.
KEGGircm:A1E_03540.
PATRICi17886097. VBIRicCan89738_0756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000409 Genomic DNA. Translation: ABV73641.1 .
RefSeqi YP_001492426.1. NC_009879.1.

3D structure databases

ProteinModelPortali A8EZ58.
SMRi A8EZ58. Positions 1-314.
ModBasei Search...

Protein-protein interaction databases

STRINGi 293613.A1E_03540.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV73641 ; ABV73641 ; A1E_03540 .
GeneIDi 5625980.
KEGGi rcm:A1E_03540.
PATRICi 17886097. VBIRicCan89738_0756.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YAPSAFV.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci RCAN293613:GHI3-710-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rickettsia canadensis."
    Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: McKiel.

Entry informationi

Entry nameiMDH_RICCK
AccessioniPrimary (citable) accession number: A8EZ58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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