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A8EZ02

- SYL_RICCK

UniProt

A8EZ02 - SYL_RICCK

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia canadensis (strain McKiel)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei605 – 6051ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRCAN293613:GHI3-653-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:A1E_03250
    OrganismiRickettsia canadensis (strain McKiel)
    Taxonomic identifieri293613 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000007056: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 834834Leucine--tRNA ligasePRO_1000009417Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi293613.A1E_03250.

    Structurei

    3D structure databases

    ProteinModelPortaliA8EZ02.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 4611"HIGH" regionAdd
    BLAST
    Motifi602 – 6065"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiPVIHCPK.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8EZ02-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQIEQKWQQ IWDDEKAFEV SNECNKPKYY VLEMLPYPSG KIHVGHVRNY    50
    SIGDVIARFM NMQGFNVLHP MGWDAFGLPA ENAAIKNNVH PKEWTYSNVD 100
    NMQQQLKSMG FAYDWSRVIN SCDPQYYKYE QKFFLELYER NLAYQKEALV 150
    NWDPVDNTVL ANEQVVDGRG WRSGAIIEKR YLKQWFLKIT DYAEELLNEI 200
    KNLKEWPEAV RSMQEKWIGK SIGANFYFKV KDNEDAIIEV FSTKPETIFG 250
    ASFIGIAFNH PIIEKLISKT PEISNFITKC LHITGSSELE KAEKDGILTS 300
    LYVIHPFDPS IILPVIITNF VLMDYGTGAI FGCPAHDERD HELAVKMNLP 350
    IKQVIEADID VHKIAYTEDG ILINSDFLNG LTNNEAKQKV IKEIEKLQIG 400
    KRSINYRLKD WGISRQRFWG CPIPMIYCKV CDIVPVPYKD LPVTLPDNVK 450
    FNGHGNPLDH HPTWKHVNCP KCDKPAIRET DTFDTFFESS WYFTRYCNSH 500
    ATDMTDKKAC DYWLPVDKYI GGIEHAVMHL LYARFFTKVM NEQNYVSVRE 550
    PFKGLFTQGM VLHATYKDEH NNWLYPDEVV KKDNKFFHKK SGNLVVQGRI 600
    EKMSKSKKNL IDLETMQKQY GADAIRLFVL SDSPPEKDLE WSVSGLEGCS 650
    RFINKLEHMF KVIASLKDDV TGINKELNRL VHLTIKYVAE DIKHFALNRA 700
    IARMRELSNA ISSEFSKEVM DVKTVKYGFN VLVQLLNPFI PHITEEIWQK 750
    LGNKERLYKT AFPAFDESML ELDTYVMAVQ VNGKLRDTYE FNNSASDYEI 800
    KQITINLPKV QKFLEGTEPK KIIFVPRKIV NIIV 834
    Length:834
    Mass (Da):96,715
    Last modified:November 13, 2007 - v1
    Checksum:iF03D4890B99F6947
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000409 Genomic DNA. Translation: ABV73585.1.
    RefSeqiWP_012148781.1. NC_009879.1.
    YP_001492370.1. NC_009879.1.

    Genome annotation databases

    EnsemblBacteriaiABV73585; ABV73585; A1E_03250.
    GeneIDi5626196.
    KEGGircm:A1E_03250.
    PATRICi17885973. VBIRicCan89738_0696.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000409 Genomic DNA. Translation: ABV73585.1 .
    RefSeqi WP_012148781.1. NC_009879.1.
    YP_001492370.1. NC_009879.1.

    3D structure databases

    ProteinModelPortali A8EZ02.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 293613.A1E_03250.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV73585 ; ABV73585 ; A1E_03250 .
    GeneIDi 5626196.
    KEGGi rcm:A1E_03250.
    PATRICi 17885973. VBIRicCan89738_0696.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi PVIHCPK.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RCAN293613:GHI3-653-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Rickettsia canadensis."
      Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: McKiel.

    Entry informationi

    Entry nameiSYL_RICCK
    AccessioniPrimary (citable) accession number: A8EZ02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3