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A8EZ02

- SYL_RICCK

UniProt

A8EZ02 - SYL_RICCK

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia canadensis (strain McKiel)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei605 – 6051ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCAN293613:GHI3-653-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:A1E_03250
OrganismiRickettsia canadensis (strain McKiel)
Taxonomic identifieri293613 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000007056: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Leucine--tRNA ligasePRO_1000009417Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi293613.A1E_03250.

Structurei

3D structure databases

ProteinModelPortaliA8EZ02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionAdd
BLAST
Motifi602 – 6065"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8EZ02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQIEQKWQQ IWDDEKAFEV SNECNKPKYY VLEMLPYPSG KIHVGHVRNY
60 70 80 90 100
SIGDVIARFM NMQGFNVLHP MGWDAFGLPA ENAAIKNNVH PKEWTYSNVD
110 120 130 140 150
NMQQQLKSMG FAYDWSRVIN SCDPQYYKYE QKFFLELYER NLAYQKEALV
160 170 180 190 200
NWDPVDNTVL ANEQVVDGRG WRSGAIIEKR YLKQWFLKIT DYAEELLNEI
210 220 230 240 250
KNLKEWPEAV RSMQEKWIGK SIGANFYFKV KDNEDAIIEV FSTKPETIFG
260 270 280 290 300
ASFIGIAFNH PIIEKLISKT PEISNFITKC LHITGSSELE KAEKDGILTS
310 320 330 340 350
LYVIHPFDPS IILPVIITNF VLMDYGTGAI FGCPAHDERD HELAVKMNLP
360 370 380 390 400
IKQVIEADID VHKIAYTEDG ILINSDFLNG LTNNEAKQKV IKEIEKLQIG
410 420 430 440 450
KRSINYRLKD WGISRQRFWG CPIPMIYCKV CDIVPVPYKD LPVTLPDNVK
460 470 480 490 500
FNGHGNPLDH HPTWKHVNCP KCDKPAIRET DTFDTFFESS WYFTRYCNSH
510 520 530 540 550
ATDMTDKKAC DYWLPVDKYI GGIEHAVMHL LYARFFTKVM NEQNYVSVRE
560 570 580 590 600
PFKGLFTQGM VLHATYKDEH NNWLYPDEVV KKDNKFFHKK SGNLVVQGRI
610 620 630 640 650
EKMSKSKKNL IDLETMQKQY GADAIRLFVL SDSPPEKDLE WSVSGLEGCS
660 670 680 690 700
RFINKLEHMF KVIASLKDDV TGINKELNRL VHLTIKYVAE DIKHFALNRA
710 720 730 740 750
IARMRELSNA ISSEFSKEVM DVKTVKYGFN VLVQLLNPFI PHITEEIWQK
760 770 780 790 800
LGNKERLYKT AFPAFDESML ELDTYVMAVQ VNGKLRDTYE FNNSASDYEI
810 820 830
KQITINLPKV QKFLEGTEPK KIIFVPRKIV NIIV
Length:834
Mass (Da):96,715
Last modified:November 13, 2007 - v1
Checksum:iF03D4890B99F6947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000409 Genomic DNA. Translation: ABV73585.1.
RefSeqiYP_001492370.1. NC_009879.1.

Genome annotation databases

EnsemblBacteriaiABV73585; ABV73585; A1E_03250.
GeneIDi5626196.
KEGGircm:A1E_03250.
PATRICi17885973. VBIRicCan89738_0696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000409 Genomic DNA. Translation: ABV73585.1 .
RefSeqi YP_001492370.1. NC_009879.1.

3D structure databases

ProteinModelPortali A8EZ02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 293613.A1E_03250.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV73585 ; ABV73585 ; A1E_03250 .
GeneIDi 5626196.
KEGGi rcm:A1E_03250.
PATRICi 17885973. VBIRicCan89738_0696.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RCAN293613:GHI3-653-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rickettsia canadensis."
    Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: McKiel.

Entry informationi

Entry nameiSYL_RICCK
AccessioniPrimary (citable) accession number: A8EZ02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3