Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A8EYX8

- NADK_RICCK

UniProt

A8EYX8 - NADK_RICCK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NAD kinase

Gene

nadK

Organism
Rickettsia canadensis (strain McKiel)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton acceptorUniRule annotation
Binding sitei49 – 491NADUniRule annotation
Binding sitei144 – 1441NADUniRule annotation
Binding sitei152 – 1521NAD; via carbonyl oxygenUniRule annotation
Binding sitei216 – 2161NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 452NADUniRule annotation
Nucleotide bindingi114 – 1152NADUniRule annotation
Nucleotide bindingi155 – 1606NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCAN293613:GHI3-629-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:A1E_03130
OrganismiRickettsia canadensis (strain McKiel)
Taxonomic identifieri293613 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
ProteomesiUP000007056: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255NAD kinasePRO_1000005440Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi293613.A1E_03130.

Structurei

3D structure databases

ProteinModelPortaliA8EYX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000139847.
KOiK00858.
OMAiHESTVSI.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A8EYX8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNINKIALIY NKDYKSLAII EEIKKLYNYC EVEEAEVIIV IGGDGALLHN
60 70 80 90 100
IHCYMHLNIP FYGVNLGSLG FLMNTLDTKN LLQNIHDSTV TILNPLLMQA
110 120 130 140 150
KDTSGQIYTA LAINEVSIFR KTNQAAKFRI DVNGIERMSE LVADGALVAT
160 170 180 190 200
PAGSSAYNLS AGGPILPLES NMLCLTPICA FRPRRWHGAL LLSSATIKFE
210 220 230 240 250
IFNTTKRPVN ATADFQEFNN IIQVTVSSTK DKPIKLLFNK NHTLEDRIIK

EQFGG
Length:255
Mass (Da):28,332
Last modified:November 13, 2007 - v1
Checksum:i52D5BBD838DFABAE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000409 Genomic DNA. Translation: ABV73561.1.
RefSeqiWP_012148757.1. NC_009879.1.
YP_001492346.1. NC_009879.1.

Genome annotation databases

EnsemblBacteriaiABV73561; ABV73561; A1E_03130.
GeneIDi5626432.
KEGGircm:A1E_03130.
PATRICi17885925. VBIRicCan89738_0672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000409 Genomic DNA. Translation: ABV73561.1 .
RefSeqi WP_012148757.1. NC_009879.1.
YP_001492346.1. NC_009879.1.

3D structure databases

ProteinModelPortali A8EYX8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 293613.A1E_03130.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV73561 ; ABV73561 ; A1E_03130 .
GeneIDi 5626432.
KEGGi rcm:A1E_03130.
PATRICi 17885925. VBIRicCan89738_0672.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000139847.
KOi K00858.
OMAi HESTVSI.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci RCAN293613:GHI3-629-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rickettsia canadensis."
    Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: McKiel.

Entry informationi

Entry nameiNADK_RICCK
AccessioniPrimary (citable) accession number: A8EYX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3