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Protein

NAD kinase

Gene

nadK

Organism
Rickettsia canadensis (strain McKiel)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Proton acceptorUniRule annotation1
Binding sitei49NADUniRule annotation1
Binding sitei144NADUniRule annotation1
Binding sitei152NAD; via carbonyl oxygenUniRule annotation1
Binding sitei216NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 45NADUniRule annotation2
Nucleotide bindingi114 – 115NADUniRule annotation2
Nucleotide bindingi155 – 160NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:A1E_03130
OrganismiRickettsia canadensis (strain McKiel)
Taxonomic identifieri293613 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000007056 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000054401 – 255NAD kinaseAdd BLAST255

Interactioni

Protein-protein interaction databases

STRINGi293613.A1E_03130.

Structurei

3D structure databases

ProteinModelPortaliA8EYX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000139847.
KOiK00858.
OMAiHESTVSI.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A8EYX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNINKIALIY NKDYKSLAII EEIKKLYNYC EVEEAEVIIV IGGDGALLHN
60 70 80 90 100
IHCYMHLNIP FYGVNLGSLG FLMNTLDTKN LLQNIHDSTV TILNPLLMQA
110 120 130 140 150
KDTSGQIYTA LAINEVSIFR KTNQAAKFRI DVNGIERMSE LVADGALVAT
160 170 180 190 200
PAGSSAYNLS AGGPILPLES NMLCLTPICA FRPRRWHGAL LLSSATIKFE
210 220 230 240 250
IFNTTKRPVN ATADFQEFNN IIQVTVSSTK DKPIKLLFNK NHTLEDRIIK

EQFGG
Length:255
Mass (Da):28,332
Last modified:November 13, 2007 - v1
Checksum:i52D5BBD838DFABAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000409 Genomic DNA. Translation: ABV73561.1.
RefSeqiWP_012148757.1. NC_009879.1.

Genome annotation databases

EnsemblBacteriaiABV73561; ABV73561; A1E_03130.
KEGGircm:A1E_03130.
PATRICi17885925. VBIRicCan89738_0672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000409 Genomic DNA. Translation: ABV73561.1.
RefSeqiWP_012148757.1. NC_009879.1.

3D structure databases

ProteinModelPortaliA8EYX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi293613.A1E_03130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV73561; ABV73561; A1E_03130.
KEGGircm:A1E_03130.
PATRICi17885925. VBIRicCan89738_0672.

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000139847.
KOiK00858.
OMAiHESTVSI.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADK_RICCK
AccessioniPrimary (citable) accession number: A8EYX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.