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A8EYU2

- PNP_RICCK

UniProt

A8EYU2 - PNP_RICCK

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Rickettsia canadensis (strain McKiel)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi487 – 4871MagnesiumUniRule annotation
    Metal bindingi493 – 4931MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciRCAN293613:GHI3-592-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:A1E_02925
    OrganismiRickettsia canadensis (strain McKiel)
    Taxonomic identifieri293613 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000007056: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 747747Polyribonucleotide nucleotidyltransferasePRO_0000329817Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi293613.A1E_02925.

    Structurei

    3D structure databases

    ProteinModelPortaliA8EYU2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini554 – 61360KHUniRule annotationAdd
    BLAST
    Domaini623 – 69169S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiGRMHIMD.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8EYU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFNEITKSVT WNGKVLELST GKIARQADGS VTVKMGNSVL LCTAVVANTA    50
    KEGIGFFPLT INYREMAYAV GKIPGGFFKR EGKASEREVL VSRLIDRPIR 100
    PLFHPAFVNE THVTCTVLSY DPETPVDILA IIGASAALAL SPAPYLEIVA 150
    ASKVGLINGE FVLNPTLELL KTSQLDLVVA GTTESVMMVE SEAHLLSEAQ 200
    MLEAVKFGFE SFQPVVKIIK ELAEEAKRPK LEMQDLYPSV LKNEIEQLFA 250
    KEIEQAFAIK SKQERSTSLD LISEKVITHF ISNIENKKYN NYQIESALKS 300
    VESDILRKEI LEKNKRIDGR STMDIRQIAC EVGLLPSAHG SALFTRGETQ 350
    SLVSSTLGTS LDEQIVDNLE GEYKERFMLN YIFPPYSVNE AMPMKAPSRR 400
    EVGHGKLAWR AINPILPNKV QFPYSIRVVA ETTESNGSSS MATVCGSSLA 450
    LMQTGIPIKA PVAGIAMGLV KEGKKFAVLS DILGDEDYFG DMDFKVAGTS 500
    EGITALQMDI KISGVDFKIM KVALEQARLG RLHILEQMNK VISKPNSELS 550
    KNAPSTTTIK IDKDKIRDII GPGGKIIKEI CETSGAKIDI SDDGTVSVYA 600
    ADRDKLKIAS DKIKAIAIEP EIGEIFNGTV TKILDSGAFI NYLGNKDGFV 650
    HISEISEERI DTVSSVIKQG DIVKVKLIGF DNKGKAKLTI KNADKDKSLN 700
    NPKPQNSINN AKENSEHVRC DSIKKRAWNE DNNAETAEFI TERKYFN 747
    Length:747
    Mass (Da):82,109
    Last modified:November 13, 2007 - v1
    Checksum:i11AA65929395FD43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000409 Genomic DNA. Translation: ABV73525.1.
    RefSeqiWP_012148722.1. NC_009879.1.
    YP_001492310.1. NC_009879.1.

    Genome annotation databases

    EnsemblBacteriaiABV73525; ABV73525; A1E_02925.
    GeneIDi5626345.
    KEGGircm:A1E_02925.
    PATRICi17885841. VBIRicCan89738_0631.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000409 Genomic DNA. Translation: ABV73525.1 .
    RefSeqi WP_012148722.1. NC_009879.1.
    YP_001492310.1. NC_009879.1.

    3D structure databases

    ProteinModelPortali A8EYU2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 293613.A1E_02925.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV73525 ; ABV73525 ; A1E_02925 .
    GeneIDi 5626345.
    KEGGi rcm:A1E_02925.
    PATRICi 17885841. VBIRicCan89738_0631.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi GRMHIMD.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci RCAN293613:GHI3-592-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Rickettsia canadensis."
      Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: McKiel.

    Entry informationi

    Entry nameiPNP_RICCK
    AccessioniPrimary (citable) accession number: A8EYU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3