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Protein

Glutamate--tRNA ligase 1

Gene

gltX1

Organism
Rickettsia canadensis (strain McKiel)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei242ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRCAN293613:G1G6U-349-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 1UniRule annotation
Short name:
GluRS 1UniRule annotation
Gene namesi
Name:gltX1UniRule annotation
Ordered Locus Names:A1E_01635
OrganismiRickettsia canadensis (strain McKiel)
Taxonomic identifieri293613 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000007056 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003677561 – 463Glutamate--tRNA ligase 1Add BLAST463

Proteomic databases

PRIDEiA8EY39

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi293613.A1E_01635

Structurei

3D structure databases

ProteinModelPortaliA8EY39
SMRiA8EY39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 20"HIGH" regionUniRule annotationAdd BLAST11
Motifi239 – 243"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A8EY39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNVITRFAP SPTGFLHIGS ARTALFNYLF ARHHNGKFLL RIEDTDKERS
60 70 80 90 100
TNEAVEAIFS GLKWLGLDWD GEVIFQSKRN DLYKETALKL LQAGKAYYCF
110 120 130 140 150
TSQEEIEKQR QKALENKQYF IFNSDWRDKD PAAYPTDIKP VIRLKTPREG
160 170 180 190 200
SITIRDTLQG DVVIENSHID DMVLLRSDGT ATYMLAVVVD DHDMGITHII
210 220 230 240 250
RGDDHLTNAA RQIAIYQACG YAVPSMTHIP LIHGADGAKL SKRHGALGVA
260 270 280 290 300
AYKDMGYLPE SVCNYLLRLG WSHGDDEIIS MDQAIKWFNL DSLGKSPAKL
310 320 330 340 350
DFANMNSLNA HYLRLLDNDS ATSKTVERLR QNYNVSKQEV IYINQAIRSL
360 370 380 390 400
LVRSETLLDL VQLAQIYLVD SPIIYKQDAK EIIENCDKDL IKQVIENLNK
410 420 430 440 450
LKQFDKESVQ NKFKEIATHN GLKLNELMKP VRALITGMTA SPSVFEIAEI
460
LGKENILKRL KII
Length:463
Mass (Da):52,518
Last modified:November 13, 2007 - v1
Checksum:i345DB7B2127C606C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000409 Genomic DNA Translation: ABV73272.1
RefSeqiWP_012148471.1, NC_009879.1

Genome annotation databases

EnsemblBacteriaiABV73272; ABV73272; A1E_01635
KEGGircm:A1E_01635

Similar proteinsi

Entry informationi

Entry nameiSYE1_RICCK
AccessioniPrimary (citable) accession number: A8EY39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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