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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Rickettsia canadensis (strain McKiel)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi301Magnesium or manganese 1UniRule annotation1
Metal bindingi315Magnesium or manganese 1UniRule annotation1
Metal bindingi315Magnesium or manganese 2UniRule annotation1
Metal bindingi317Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi181 – 232ATPUniRule annotationAdd BLAST52

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:A1E_01430
OrganismiRickettsia canadensis (strain McKiel)
Taxonomic identifieri293613 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
Proteomesi
  • UP000007056 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000747811 – 354D-alanine--D-alanine ligaseAdd BLAST354

Interactioni

Protein-protein interaction databases

STRINGi293613.A1E_01430.

Structurei

3D structure databases

ProteinModelPortaliA8EXZ8.
SMRiA8EXZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 348ATP-graspUniRule annotationAdd BLAST195

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPF. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000011592.
KOiK01921.
OMAiYETKYTE.
OrthoDBiPOG091H00GT.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
IPR022436. RPE2.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
TIGR03774. RPE2. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A8EXZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHQYQIHWVE HSEVKILSNI VVRLEYKERG VKSITNRRAR HDAVSESKSI
60 70 80 90 100
DYSGKKHIAL VAGGMSAERE VSLVSSKGVS KALIALGYKV TFIDMGADIA
110 120 130 140 150
FKLQEIKPDI VFNCLHGTYG EDGCLSGLLN IMRIPYTHSG VLSSALAFDK
160 170 180 190 200
IYSRSWFLTN NINMAESIVV NKSDNIKIEP MKRPYVIKPI TQGSSIGIEV
210 220 230 240 250
IFEEDDFNFA NYDFPYGDQV IIEKYIKGRE LQVAVLNGKA LGVLEIKLLK
260 270 280 290 300
NRFYDYETKY TEGFAEHLCP APIPTNLYDK LLIESEKIYK TMNCKGPARV
310 320 330 340 350
EFLLEDQTNK LYALEINTHP GMTPLSIVPE IAAYAGINFT NLIEEIIKAA

SFES
Length:354
Mass (Da):39,848
Last modified:November 13, 2007 - v1
Checksum:i6F5D21B9135895D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000409 Genomic DNA. Translation: ABV73231.1.
RefSeqiWP_012148430.1. NC_009879.1.

Genome annotation databases

EnsemblBacteriaiABV73231; ABV73231; A1E_01430.
KEGGircm:A1E_01430.

Similar proteinsi

Entry informationi

Entry nameiDDL_RICCK
AccessioniPrimary (citable) accession number: A8EXZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: August 30, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families