Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A8EXZ8 (DDL_RICCK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:A1E_01430
OrganismRickettsia canadensis (strain McKiel) [Complete proteome] [HAMAP]
Taxonomic identifier293613 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000074781

Regions

Domain154 – 348195ATP-grasp
Nucleotide binding181 – 23252ATP By similarity

Sites

Metal binding3011Magnesium or manganese 1 By similarity
Metal binding3151Magnesium or manganese 1 By similarity
Metal binding3151Magnesium or manganese 2 By similarity
Metal binding3171Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
A8EXZ8 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: 6F5D21B9135895D7

FASTA35439,848
        10         20         30         40         50         60 
MHQYQIHWVE HSEVKILSNI VVRLEYKERG VKSITNRRAR HDAVSESKSI DYSGKKHIAL 

        70         80         90        100        110        120 
VAGGMSAERE VSLVSSKGVS KALIALGYKV TFIDMGADIA FKLQEIKPDI VFNCLHGTYG 

       130        140        150        160        170        180 
EDGCLSGLLN IMRIPYTHSG VLSSALAFDK IYSRSWFLTN NINMAESIVV NKSDNIKIEP 

       190        200        210        220        230        240 
MKRPYVIKPI TQGSSIGIEV IFEEDDFNFA NYDFPYGDQV IIEKYIKGRE LQVAVLNGKA 

       250        260        270        280        290        300 
LGVLEIKLLK NRFYDYETKY TEGFAEHLCP APIPTNLYDK LLIESEKIYK TMNCKGPARV 

       310        320        330        340        350 
EFLLEDQTNK LYALEINTHP GMTPLSIVPE IAAYAGINFT NLIEEIIKAA SFES 

« Hide

References

[1]"Complete genome sequence of Rickettsia canadensis."
Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M.
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: McKiel.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000409 Genomic DNA. Translation: ABV73231.1.
RefSeqYP_001492016.1. NC_009879.1.

3D structure databases

ProteinModelPortalA8EXZ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING293613.A1E_01430.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABV73231; ABV73231; A1E_01430.
GeneID5626289.
KEGGrcm:A1E_01430.
PATRIC17885175. VBIRicCan89738_0310.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAKYTEGFA.
OrthoDBEOG6ND0KB.
ProtClustDBPRK01372.

Enzyme and pathway databases

BioCycRCAN293613:GHI3-287-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
IPR022436. RPE2.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
TIGR03774. RPE2. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_RICCK
AccessionPrimary (citable) accession number: A8EXZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways