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A8EXV2

- DEF_RICCK

UniProt

A8EXV2 - DEF_RICCK

Protein

Peptide deformylase

Gene

def

Organism
Rickettsia canadensis (strain McKiel)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi99 – 991IronUniRule annotation
    Metal bindingi141 – 1411IronUniRule annotation
    Active sitei142 – 1421UniRule annotation
    Metal bindingi145 – 1451IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciRCAN293613:GHI3-238-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:A1E_01200
    OrganismiRickettsia canadensis (strain McKiel)
    Taxonomic identifieri293613 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group
    ProteomesiUP000007056: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 175175Peptide deformylasePRO_1000023134Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi293613.A1E_01200.

    Structurei

    3D structure databases

    ProteinModelPortaliA8EXV2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243509.
    KOiK01462.
    OMAiQQANNST.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8EXV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSILPIVTAP DERLKQKSHR VLEVTDQTRK FMDDMLKTMY HEDAAGLAAV    50
    QVGILKRILV IDIKDHDPVE RPKDFYPLFI VNPDIIDKSE ELVTANEGCI 100
    SVPRQRVEVA RPESIKIKYL DYHNKQQELE ANDWLARVIQ HEYDHLEGKL 150
    MIDYLSSLKR DVVLRKLKKL KNNIV 175
    Length:175
    Mass (Da):20,399
    Last modified:November 13, 2007 - v1
    Checksum:i2E6D5E1ABCC9EF5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000409 Genomic DNA. Translation: ABV73185.1.
    RefSeqiYP_001491970.1. NC_009879.1.

    Genome annotation databases

    EnsemblBacteriaiABV73185; ABV73185; A1E_01200.
    GeneIDi5626146.
    KEGGircm:A1E_01200.
    PATRICi17885065. VBIRicCan89738_0258.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000409 Genomic DNA. Translation: ABV73185.1 .
    RefSeqi YP_001491970.1. NC_009879.1.

    3D structure databases

    ProteinModelPortali A8EXV2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 293613.A1E_01200.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV73185 ; ABV73185 ; A1E_01200 .
    GeneIDi 5626146.
    KEGGi rcm:A1E_01200.
    PATRICi 17885065. VBIRicCan89738_0258.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243509.
    KOi K01462.
    OMAi QQANNST.
    OrthoDBi EOG664CMF.

    Enzyme and pathway databases

    BioCyci RCAN293613:GHI3-238-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Rickettsia canadensis."
      Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M.
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: McKiel.

    Entry informationi

    Entry nameiDEF_RICCK
    AccessioniPrimary (citable) accession number: A8EXV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3