Reviewed,
UniProtKB/Swiss-Prot A8EXI2 (LEP_RICCK)
Last modified
July 13, 2010.
Version 28.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and originHide
| Protein names | Recommended name: Signal peptidase I Short name=SPase I EC=3.4.21.89 Alternative name(s): Leader peptidase I | ||||
| Gene names |
| ||||
| Organism | Rickettsia canadensis (strain McKiel) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 293613 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group |
Protein attributesHide
| Sequence length | 265 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)Hide
| Catalytic activity | Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins. |
| Subcellular location | Cell inner membrane; Single-pass type II membrane protein Potential. |
| Sequence similarities | Belongs to the peptidase S26 family. |
OntologiesHide
| Keywords | |
|---|---|
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | serine-type peptidase activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)Hide
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 265 | 265 | Signal peptidase I | PRO_0000316274 | |||||
Regions | |||||||||
| Topological domain | 1 – 19 | 19 | Cytoplasmic Potential | ||||||
| Transmembrane | 20 – 40 | 21 | Helical; Potential | ||||||
| Topological domain | 41 – 265 | 225 | Periplasmic Potential | ||||||
Sites | |||||||||
| Active site | 44 | 1 | By similarity | ||||||
| Active site | 107 | 1 | By similarity | ||||||
SequencesHide
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ReferencesHide
| [1] | "Complete genome sequence of Rickettsia canadensis." Madan A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Dasch G., Eremeeva M. Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-referencesHide
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000409 Genomic DNA. Translation: ABV73065.1. |
| RefSeq | YP_001491850.1. |
3D structure databases | |
| SMR | A8EXI2. Positions 31-239. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A8EXI2. |
Genome annotation databases | |
| GeneID | 5626394. |
| GenomeReviews | Gene locus A1E_00585 in contig CP000409_GR. |
| KEGG | rcm:A1E_00585. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG0681. |
| HOGENOM | HBG596607. |
| OMA | KPWIESV. |
| ProtClustDB | CLSK870751. |
Family and domain databases | |
| InterPro | IPR000223. Pept_S26A_signal_pept_1. IPR019758. Pept_S26A_signal_pept_1_CS. IPR019757. Pept_S26A_signal_pept_1_Lys-AS. IPR019759. Peptidase_S24_S26_cons-reg. IPR015927. Peptidase_S24_S26A/B/C. IPR011056. Peptidase_S24_S26A/B/C_b-rbn. [Graphical view] |
| Gene3D | G3DSA:2.10.109.10. Pept_S24_S26_C. 1 hit. |
| Pfam | PF00717. Peptidase_S24. 1 hit. [Graphical view] |
| PRINTS | PR00727. LEADERPTASE. |
| SUPFAM | SSF51306. Pept_S24_S26_C. 1 hit. |
| TIGRFAMs | TIGR02227. sigpep_I_bact. 1 hit. |
| PROSITE | PS00760. SPASE_I_2. 1 hit. PS00761. SPASE_I_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry informationHide
| Entry name | LEP_RICCK | ||||||||
| Accession | Primary (citable) accession number: A8EXI2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documentsHide
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


