A8EWV7 (A8EWV7_ARCB4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid A disaccharide synthase EMBL ABV68430.1
EC=2.4.1.182 EMBL ABV68430.1

Gene names

Name:	lpxB EMBL ABV68430.1
Ordered Locus Names:	Abu_2217

Organism

Arcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]

Taxonomic identifier

367737 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL ABV68430.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8EWV7 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: E8BC116D7EE72BD8	FASTA	347	40,227
	10 20 30 40 50 60 MKLLVCAMET SSNIHLKELK KYLDDDIELI GVFDKELGNP LYDLTTLAIM GFVDALKKLR 70 80 90 100 110 120 FFFRLRDELV ELACDCDKVL LMDSSGFNLP LAKKLRETYP NKEIIYYILP QAWAWKKGRV 130 140 150 160 170 180 KKLEAYCSKL CSIIPFESEI YNDKNKITYV GHPLLDEIKE FKTTFIETNK IAFMPGSRKT 190 200 210 220 230 240 EITNLLPIFK ELVKKIPNKE YILIIPSKFD DEYIKKIYGD INEFSISRNA HESLLEAEYA 250 260 270 280 290 300 FICSGTATLE AALIGTPFTL SYIAKRFDFF IGKLFVKLNF VGLANIFFEK MGKEPLHSEF 310 320 330 340 LQENVTVENL FNDYNTLNKE QFFNNSKLLR EYLKNGSSQN MAQIIKN

References

[1]

"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri." Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E. PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000361 Genomic DNA. Translation: ABV68430.1.
RefSeq	YP_001491100.1. NC_009850.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8EWV7.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5623491.
GenomeReviews	Gene locus Abu_2217 in contig CP000361_GR.
KEGG	abu:Abu_2217.
PATRIC	20965800. VBIArcBut20197_2161.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	NANEKAA.
ProtClustDB	PRK14089.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A8EWV7_ARCB4

Accession

Primary (citable) accession number: A8EWV7

Entry history

Integrated into UniProtKB/TrEMBL:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)