A8EWM0 (SYR_ARCB4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	Abu_2129

Organism

Arcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]

Taxonomic identifier

367737 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 529	529	Arginine--tRNA ligase HAMAP MF_00123		PRO_1000057806
Regions
	Motif	113 – 123	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	A8EWM0 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 5FA7D83A08CE371E	FASTA	529	60,326
	10 20 30 40 50 60 MQNLVKEFIE KVLETNIVLE KPKDVSLGHY ATPVAFSLAK ELKKSPMLIA QELVTKLENP 70 80 90 100 110 120 SLFEKIEAVN GFINFKLSPL FLQSLVDDAL SNKENFAKQH KKSEKILLEY VSANPTGPLH 130 140 150 160 170 180 IGHARGAIFG DSLARVGKYL GYDITTEYYI NDAGSQMDLL GLSVNLAARD FIYGEDVSYP 190 200 210 220 230 240 EVYYRGDYLI DIANQIIQDY GKDYLYDEKN FKDIALLGKD FVMNLIIKDL KDLGIEFDNF 250 260 270 280 290 300 VSEKSLYSSW NETKRVLEEN GSLYDKDDKT YLKSTQYGDD SDRVVVRDNG IPTYLAGDII 310 320 330 340 350 360 YHKNKYDRNF DRYINIWGAD HHGYITRVKA AIEFLGNDSS KLEVLLSQMV QLLKGGEPYK 370 380 390 400 410 420 MSKRKGNVIL MSEITEEIGS DALRFIFLTK KSDTHLEFDI DTLKNQDSSN PIFYINYAHA 430 440 450 460 470 480 RINQVFVKAG VNFDDIKDIS FEKLNQDGLN LVYESLLLES ILVEAFAKRD MQKITEYLYN 490 500 510 520 LASSIHKFYN EHKIIGSDEQ NLYLKVLSIA ALSIKVGLKL LGIEAKEIM

References

[1]

"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri." Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E. PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RM4018.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000361 Genomic DNA. Translation: ABV68343.1.
RefSeq	YP_001491013.1. NC_009850.1.
3D structure databases
ProteinModelPortal	A8EWM0.
ModBase	Search...
Protein-protein interaction databases
STRING	A8EWM0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5624606.
GenomeReviews	Gene locus Abu_2129 in contig CP000361_GR.
KEGG	abu:Abu_2129.
PATRIC	20965622. VBIArcBut20197_2072.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0018.
HOGENOM	HBG695395.
OMA	FDVYFHE.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	ABUT367737:ABU_2129-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_ARCB4

Accession

Primary (citable) accession number: A8EWM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program