Reviewed, UniProtKB/Swiss-Prot A8EWG2 (ARGB_ARCB4)

Names and origin

Protein names

Recommended name:
    Acetylglutamate kinase
    EC=2.7.2.8
Alternative name(s):
    NAG kinase
      Short name=AGK
    N-acetyl-L-glutamate 5-phosphotransferase

Gene names

Name:	argB
Ordered Locus Names:	Abu_2068

Organism

Arcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]

Taxonomic identifier

367737 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP acetylglutamate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Acetylglutamate kinase HAMAP MF_00082		PRO_1000057537
Regions
	Region	64 – 65	2	Substrate binding By similarity
Sites
	Binding site	86	1	Substrate By similarity
	Binding site	181	1	Substrate By similarity
	Site	29	1	Transition state stabilizer By similarity
	Site	241	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8EWG2-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: A10AB968BB8A3A2C	FASTA	301	32,330
	10 20 30 40 50 60 MAQTNPKVQT LIDAIPYFKK FYGKTIVIKY GGSAQTSDDL KEKFAQDIVL LTLLGIKPVV 70 80 90 100 110 120 VHGGGARITE LLNKLEIPSS FVDGYRVTCK ESMRVVEMVL SGEINKNIAS LLNFHGAKAI 130 140 150 160 170 180 GISGKDSGII KAVPKDGGKF GYTGDITSVN GELINNLIKE GFIPVIAPIA NGDEANHPGF 190 200 210 220 230 240 NINADVAACE IAMALKAQKV IFLTDTIGVL NKSGELIQTL DKANVEMFKK DGTIAGGMIP 250 260 270 280 290 300 KVDSCIEAIH NGVNKAHIID GRVEHSILLE LFTSDGIGTQ FIRVDNPNNG IDIEKLLNKQ D

References

[1]

"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri." Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E. PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000361 Genomic DNA. Translation: ABV68285.1.
RefSeq	YP_001490955.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8EWG2.
Genome annotation databases
GeneID	5624882.
GenomeReviews	Gene locus Abu_2068 in contig CP000361_GR.
KEGG	abu:Abu_2068.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FVIKYGG.
Family and domain databases
HAMAP	MF_00082. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR011148. GlcNAc_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
TIGRFAMs	TIGR00761. argB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ARCB4

Accession

Primary (citable) accession number: A8EWG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	November 3, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)