A8EWE5 (AROA_ARCB4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Abu_2051

Organism

Arcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]

Taxonomic identifier

367737 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 425	425	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000099664

Sequences

	Sequence		Length	Mass (Da)
	A8EWE5 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: EF0AF824298094EA	FASTA	425	47,047
	10 20 30 40 50 60 MEKFNIKKLT KPFNIEIDSI ASDKSISHRC AMFSLFSNQT SYIKNYLTAE DTLNTLSIVE 70 80 90 100 110 120 QLGAKIKRDG SYVEITPTST LTEPSDVLDC GNSGTAMRLF CGLLASVEGS FILTGDKYLR 130 140 150 160 170 180 NRPMKRVADP LRSIGALIDG RENGNKAPLF IRGVKELKPF TYHSPVDSAQ VKSAMILAAL 190 200 210 220 230 240 RANGISRYKE NELTRDHTER MLNGMGATLE YDNDGFINIH PLNGHLKPLN ITVPTDPSSA 250 260 270 280 290 300 FFFAVAAAIT SKSRVLIKNV TLNPTRVEAY QVLKRMGVIV NFIEKENVYE PIGDIEVINN 310 320 330 340 350 360 ELNGVDVSEN ISWLIDELPA LSIAMSLAKG KSKVSNAKEL RVKESDRISS VVNNLKLCKV 370 380 390 400 410 420 DFTEFEDGYE IVGGSLQKAV IDSHGDHRIA MSFAIAGLNC DMDIEDIQCI ETSFPNFKEI LDSLY

References

[1]

"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri." Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E. PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RM4018.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000361 Genomic DNA. Translation: ABV68268.1.
RefSeq	YP_001490938.1. NC_009850.1.
3D structure databases
ProteinModelPortal	A8EWE5.
ModBase	Search...
Protein-protein interaction databases
STRING	A8EWE5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5625293.
GenomeReviews	Gene locus Abu_2051 in contig CP000361_GR.
KEGG	abu:Abu_2051.
PATRIC	20965468. VBIArcBut20197_1998.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	GEDPRST.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	ABUT367737:ABU_2051-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_ARCB4

Accession

Primary (citable) accession number: A8EWE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program