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A8EWD7

- IF2_ARCB4

UniProt

A8EWD7 - IF2_ARCB4

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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Arcobacter butzleri (strain RM4018)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi396 – 4038GTPUniRule annotation
Nucleotide bindingi442 – 4465GTPUniRule annotation
Nucleotide bindingi496 – 4994GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: UniProtKB-HAMAP
  2. GTP binding Source: UniProtKB-KW
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciABUT367737:GHWO-2041-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Abu_2043
OrganismiArcobacter butzleri (strain RM4018)
Taxonomic identifieri367737 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
ProteomesiUP000001136: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 890890Translation initiation factor IF-2PRO_0000335455Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi367737.Abu_2043.

Structurei

3D structure databases

ProteinModelPortaliA8EWD7.
SMRiA8EWD7. Positions 791-883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini387 – 554168tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni396 – 4038G1By similarity
Regioni421 – 4255G2By similarity
Regioni442 – 4454G3By similarity
Regioni496 – 4994G4By similarity
Regioni532 – 5343G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiCTIDIDY.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8EWD7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDTVRVYEI AEEAGASSQD VIAKAKDLGI ELKSPQTAVS YEDAEEITKY
60 70 80 90 100
MMTGKSERLA TKPAKVKKVV KKEEVKKETE EIETPKEKIE TVQKVEKEII
110 120 130 140 150
KKPELKKVEI SKPISKAPQK SEEESENLEN PNKIVPKRKG LVIIKKKRPK
160 170 180 190 200
EEELEEQQTI TENQSKKQMK SLSEILGGVD DEEKSYNEPK NKENDDIKKQ
210 220 230 240 250
KVKKEKKKPL IKTQDHGKKL DVDREYSDEF ASSDDSLLGE EIVLLDMDLS
260 270 280 290 300
DSYKIFDEPK PQNIVNQSRS SKPAAFGNVP QGLKRGKRKK RIVRTQEKAE
310 320 330 340 350
ITSVTIPEDI RVYEFAEACG KSPAEVITVL FSLGMMVTKN DFLKQDELEI
360 370 380 390 400
LGEEFGIEVT VKDALEDVNY VETYNDEEDI DTSSFVTRPP VVTIMGHVDH
410 420 430 440 450
GKTSLLDKIR SSKVAAGEAG GITQHITSYT VTKNGQEITF VDTPGHAAFS
460 470 480 490 500
AMRARGANVT DIIIIVVAAD DGVKMQTEEV ISHAKASGCP IIVAMNKMDK
510 520 530 540 550
ETANPDMVKA QMAEKGLTPI DWGGDIEFIG VSARTGDGIE DLLENILLQA
560 570 580 590 600
EILELKADPT AKAKATVIEA SLEKGRGPVA NVIVQNGTLK IGDNIVCDTT
610 620 630 640 650
FGRVKAITDD NGKPVKELGL SQTGTVLGLN EVPTTGSVLV AMDTEKEVRE
660 670 680 690 700
IATTRAEHAR AKELSKSTKV SLEEMSGLIA EGKIKQLPVI IKADVGGSLE
710 720 730 740 750
AIKGSLEKIA NDEVKVKVVH AAVGGITESD LVLAGASGEC IILGFNVRPT
760 770 780 790 800
GSVKAKAKAD GVTINTYSII YDLIDDVKHA LSGMMSAVIR EENTGQAEVR
810 820 830 840 850
DTFVVPKVGT VAGCLVTDGK VIRGGHARII RDGVVTYTGK ISSLKRFKDD
860 870 880 890
VKEVANGYEC GIMFDKFNDI KVGDFIETFI QIEEKVSVDD
Length:890
Mass (Da):97,262
Last modified:November 13, 2007 - v1
Checksum:i59D97729EA9DF258
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000361 Genomic DNA. Translation: ABV68260.1.
RefSeqiWP_012147925.1. NC_009850.1.
YP_001490930.1. NC_009850.1.

Genome annotation databases

EnsemblBacteriaiABV68260; ABV68260; Abu_2043.
GeneIDi5625285.
KEGGiabu:Abu_2043.
PATRICi20965452. VBIArcBut20197_1990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000361 Genomic DNA. Translation: ABV68260.1 .
RefSeqi WP_012147925.1. NC_009850.1.
YP_001490930.1. NC_009850.1.

3D structure databases

ProteinModelPortali A8EWD7.
SMRi A8EWD7. Positions 791-883.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 367737.Abu_2043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV68260 ; ABV68260 ; Abu_2043 .
GeneIDi 5625285.
KEGGi abu:Abu_2043.
PATRICi 20965452. VBIArcBut20197_1990.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi CTIDIDY.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci ABUT367737:GHWO-2041-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RM4018.

Entry informationi

Entry nameiIF2_ARCB4
AccessioniPrimary (citable) accession number: A8EWD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3