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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Arcobacter butzleri (strain RM4018)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi396 – 403GTPUniRule annotation8
Nucleotide bindingi442 – 446GTPUniRule annotation5
Nucleotide bindingi496 – 499GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciABUT367737:G1G6I-2046-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:Abu_2043
OrganismiArcobacter butzleri (strain RM4018)
Taxonomic identifieri367737 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
Proteomesi
  • UP000001136 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003354551 – 890Translation initiation factor IF-2Add BLAST890

Proteomic databases

PRIDEiA8EWD7

Interactioni

Protein-protein interaction databases

STRINGi367737.Abu_2043

Structurei

3D structure databases

ProteinModelPortaliA8EWD7
SMRiA8EWD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini387 – 554tr-type GAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni396 – 403G1By similarity8
Regioni421 – 425G2By similarity5
Regioni442 – 445G3By similarity4
Regioni496 – 499G4By similarity4
Regioni532 – 534G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QHU Bacteria
COG0532 LUCA
HOGENOMiHOG000076906
KOiK02519
OMAiDNRTGGY
OrthoDBiPOG091H00EY

Family and domain databases

Gene3Di3.40.50.10050, 1 hit
HAMAPiMF_00100_B IF_2_B, 1 hit
InterProiView protein in InterPro
IPR006847 IF2_N
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR000178 TF_IF2_bacterial-like
IPR015760 TIF_IF2
IPR023115 TIF_IF2_dom3
IPR036925 TIF_IF2_dom3_sf
IPR009000 Transl_B-barrel_sf
PANTHERiPTHR43381 PTHR43381, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF11987 IF-2, 1 hit
PF04760 IF2_N, 2 hits
SUPFAMiSSF50447 SSF50447, 2 hits
SSF52156 SSF52156, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00487 IF-2, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit
PS01176 IF2, 1 hit

Sequencei

Sequence statusi: Complete.

A8EWD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTVRVYEI AEEAGASSQD VIAKAKDLGI ELKSPQTAVS YEDAEEITKY
60 70 80 90 100
MMTGKSERLA TKPAKVKKVV KKEEVKKETE EIETPKEKIE TVQKVEKEII
110 120 130 140 150
KKPELKKVEI SKPISKAPQK SEEESENLEN PNKIVPKRKG LVIIKKKRPK
160 170 180 190 200
EEELEEQQTI TENQSKKQMK SLSEILGGVD DEEKSYNEPK NKENDDIKKQ
210 220 230 240 250
KVKKEKKKPL IKTQDHGKKL DVDREYSDEF ASSDDSLLGE EIVLLDMDLS
260 270 280 290 300
DSYKIFDEPK PQNIVNQSRS SKPAAFGNVP QGLKRGKRKK RIVRTQEKAE
310 320 330 340 350
ITSVTIPEDI RVYEFAEACG KSPAEVITVL FSLGMMVTKN DFLKQDELEI
360 370 380 390 400
LGEEFGIEVT VKDALEDVNY VETYNDEEDI DTSSFVTRPP VVTIMGHVDH
410 420 430 440 450
GKTSLLDKIR SSKVAAGEAG GITQHITSYT VTKNGQEITF VDTPGHAAFS
460 470 480 490 500
AMRARGANVT DIIIIVVAAD DGVKMQTEEV ISHAKASGCP IIVAMNKMDK
510 520 530 540 550
ETANPDMVKA QMAEKGLTPI DWGGDIEFIG VSARTGDGIE DLLENILLQA
560 570 580 590 600
EILELKADPT AKAKATVIEA SLEKGRGPVA NVIVQNGTLK IGDNIVCDTT
610 620 630 640 650
FGRVKAITDD NGKPVKELGL SQTGTVLGLN EVPTTGSVLV AMDTEKEVRE
660 670 680 690 700
IATTRAEHAR AKELSKSTKV SLEEMSGLIA EGKIKQLPVI IKADVGGSLE
710 720 730 740 750
AIKGSLEKIA NDEVKVKVVH AAVGGITESD LVLAGASGEC IILGFNVRPT
760 770 780 790 800
GSVKAKAKAD GVTINTYSII YDLIDDVKHA LSGMMSAVIR EENTGQAEVR
810 820 830 840 850
DTFVVPKVGT VAGCLVTDGK VIRGGHARII RDGVVTYTGK ISSLKRFKDD
860 870 880 890
VKEVANGYEC GIMFDKFNDI KVGDFIETFI QIEEKVSVDD
Length:890
Mass (Da):97,262
Last modified:November 13, 2007 - v1
Checksum:i59D97729EA9DF258
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000361 Genomic DNA Translation: ABV68260.1
RefSeqiWP_012147925.1, NC_009850.1

Genome annotation databases

EnsemblBacteriaiABV68260; ABV68260; Abu_2043
GeneIDi24303366
KEGGiabu:Abu_2043

Similar proteinsi

Entry informationi

Entry nameiIF2_ARCB4
AccessioniPrimary (citable) accession number: A8EWD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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