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A8EWD7

- IF2_ARCB4

UniProt

A8EWD7 - IF2_ARCB4

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Arcobacter butzleri (strain RM4018)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi396 – 4038GTPUniRule annotation
    Nucleotide bindingi442 – 4465GTPUniRule annotation
    Nucleotide bindingi496 – 4994GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciABUT367737:GHWO-2041-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:Abu_2043
    OrganismiArcobacter butzleri (strain RM4018)
    Taxonomic identifieri367737 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
    ProteomesiUP000001136: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 890890Translation initiation factor IF-2PRO_0000335455Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi367737.Abu_2043.

    Structurei

    3D structure databases

    ProteinModelPortaliA8EWD7.
    SMRiA8EWD7. Positions 791-883.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini387 – 554168tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni396 – 4038G1By similarity
    Regioni421 – 4255G2By similarity
    Regioni442 – 4454G3By similarity
    Regioni496 – 4994G4By similarity
    Regioni532 – 5343G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiCTIDIDY.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8EWD7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDTVRVYEI AEEAGASSQD VIAKAKDLGI ELKSPQTAVS YEDAEEITKY    50
    MMTGKSERLA TKPAKVKKVV KKEEVKKETE EIETPKEKIE TVQKVEKEII 100
    KKPELKKVEI SKPISKAPQK SEEESENLEN PNKIVPKRKG LVIIKKKRPK 150
    EEELEEQQTI TENQSKKQMK SLSEILGGVD DEEKSYNEPK NKENDDIKKQ 200
    KVKKEKKKPL IKTQDHGKKL DVDREYSDEF ASSDDSLLGE EIVLLDMDLS 250
    DSYKIFDEPK PQNIVNQSRS SKPAAFGNVP QGLKRGKRKK RIVRTQEKAE 300
    ITSVTIPEDI RVYEFAEACG KSPAEVITVL FSLGMMVTKN DFLKQDELEI 350
    LGEEFGIEVT VKDALEDVNY VETYNDEEDI DTSSFVTRPP VVTIMGHVDH 400
    GKTSLLDKIR SSKVAAGEAG GITQHITSYT VTKNGQEITF VDTPGHAAFS 450
    AMRARGANVT DIIIIVVAAD DGVKMQTEEV ISHAKASGCP IIVAMNKMDK 500
    ETANPDMVKA QMAEKGLTPI DWGGDIEFIG VSARTGDGIE DLLENILLQA 550
    EILELKADPT AKAKATVIEA SLEKGRGPVA NVIVQNGTLK IGDNIVCDTT 600
    FGRVKAITDD NGKPVKELGL SQTGTVLGLN EVPTTGSVLV AMDTEKEVRE 650
    IATTRAEHAR AKELSKSTKV SLEEMSGLIA EGKIKQLPVI IKADVGGSLE 700
    AIKGSLEKIA NDEVKVKVVH AAVGGITESD LVLAGASGEC IILGFNVRPT 750
    GSVKAKAKAD GVTINTYSII YDLIDDVKHA LSGMMSAVIR EENTGQAEVR 800
    DTFVVPKVGT VAGCLVTDGK VIRGGHARII RDGVVTYTGK ISSLKRFKDD 850
    VKEVANGYEC GIMFDKFNDI KVGDFIETFI QIEEKVSVDD 890
    Length:890
    Mass (Da):97,262
    Last modified:November 13, 2007 - v1
    Checksum:i59D97729EA9DF258
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000361 Genomic DNA. Translation: ABV68260.1.
    RefSeqiWP_012147925.1. NC_009850.1.
    YP_001490930.1. NC_009850.1.

    Genome annotation databases

    EnsemblBacteriaiABV68260; ABV68260; Abu_2043.
    GeneIDi5625285.
    KEGGiabu:Abu_2043.
    PATRICi20965452. VBIArcBut20197_1990.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000361 Genomic DNA. Translation: ABV68260.1 .
    RefSeqi WP_012147925.1. NC_009850.1.
    YP_001490930.1. NC_009850.1.

    3D structure databases

    ProteinModelPortali A8EWD7.
    SMRi A8EWD7. Positions 791-883.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 367737.Abu_2043.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV68260 ; ABV68260 ; Abu_2043 .
    GeneIDi 5625285.
    KEGGi abu:Abu_2043.
    PATRICi 20965452. VBIArcBut20197_1990.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi CTIDIDY.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci ABUT367737:GHWO-2041-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RM4018.

    Entry informationi

    Entry nameiIF2_ARCB4
    AccessioniPrimary (citable) accession number: A8EWD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3