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A8EWD7

- IF2_ARCB4

UniProt

A8EWD7 - IF2_ARCB4

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Protein
Translation initiation factor IF-2
Gene
infB, Abu_2043
Organism
Arcobacter butzleri (strain RM4018)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi396 – 4038GTP By similarity
Nucleotide bindingi442 – 4465GTP By similarity
Nucleotide bindingi496 – 4994GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: UniProtKB-HAMAP
  3. translation initiation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciABUT367737:GHWO-2041-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2
Gene namesi
Name:infB
Ordered Locus Names:Abu_2043
OrganismiArcobacter butzleri (strain RM4018)
Taxonomic identifieri367737 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
ProteomesiUP000001136: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 890890Translation initiation factor IF-2UniRule annotation
PRO_0000335455Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi367737.Abu_2043.

Structurei

3D structure databases

ProteinModelPortaliA8EWD7.
SMRiA8EWD7. Positions 791-883.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini387 – 554168tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni396 – 4038G1 By similarity
Regioni421 – 4255G2 By similarity
Regioni442 – 4454G3 By similarity
Regioni496 – 4994G4 By similarity
Regioni532 – 5343G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0532.
HOGENOMiHOG000076906.
KOiK02519.
OMAiCTIDIDY.
OrthoDBiEOG67HJSV.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00100_B. IF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8EWD7-1 [UniParc]FASTAAdd to Basket

« Hide

MSDTVRVYEI AEEAGASSQD VIAKAKDLGI ELKSPQTAVS YEDAEEITKY    50
MMTGKSERLA TKPAKVKKVV KKEEVKKETE EIETPKEKIE TVQKVEKEII 100
KKPELKKVEI SKPISKAPQK SEEESENLEN PNKIVPKRKG LVIIKKKRPK 150
EEELEEQQTI TENQSKKQMK SLSEILGGVD DEEKSYNEPK NKENDDIKKQ 200
KVKKEKKKPL IKTQDHGKKL DVDREYSDEF ASSDDSLLGE EIVLLDMDLS 250
DSYKIFDEPK PQNIVNQSRS SKPAAFGNVP QGLKRGKRKK RIVRTQEKAE 300
ITSVTIPEDI RVYEFAEACG KSPAEVITVL FSLGMMVTKN DFLKQDELEI 350
LGEEFGIEVT VKDALEDVNY VETYNDEEDI DTSSFVTRPP VVTIMGHVDH 400
GKTSLLDKIR SSKVAAGEAG GITQHITSYT VTKNGQEITF VDTPGHAAFS 450
AMRARGANVT DIIIIVVAAD DGVKMQTEEV ISHAKASGCP IIVAMNKMDK 500
ETANPDMVKA QMAEKGLTPI DWGGDIEFIG VSARTGDGIE DLLENILLQA 550
EILELKADPT AKAKATVIEA SLEKGRGPVA NVIVQNGTLK IGDNIVCDTT 600
FGRVKAITDD NGKPVKELGL SQTGTVLGLN EVPTTGSVLV AMDTEKEVRE 650
IATTRAEHAR AKELSKSTKV SLEEMSGLIA EGKIKQLPVI IKADVGGSLE 700
AIKGSLEKIA NDEVKVKVVH AAVGGITESD LVLAGASGEC IILGFNVRPT 750
GSVKAKAKAD GVTINTYSII YDLIDDVKHA LSGMMSAVIR EENTGQAEVR 800
DTFVVPKVGT VAGCLVTDGK VIRGGHARII RDGVVTYTGK ISSLKRFKDD 850
VKEVANGYEC GIMFDKFNDI KVGDFIETFI QIEEKVSVDD 890
Length:890
Mass (Da):97,262
Last modified:November 13, 2007 - v1
Checksum:i59D97729EA9DF258
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000361 Genomic DNA. Translation: ABV68260.1.
RefSeqiWP_012147925.1. NC_009850.1.
YP_001490930.1. NC_009850.1.

Genome annotation databases

EnsemblBacteriaiABV68260; ABV68260; Abu_2043.
GeneIDi5625285.
KEGGiabu:Abu_2043.
PATRICi20965452. VBIArcBut20197_1990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000361 Genomic DNA. Translation: ABV68260.1 .
RefSeqi WP_012147925.1. NC_009850.1.
YP_001490930.1. NC_009850.1.

3D structure databases

ProteinModelPortali A8EWD7.
SMRi A8EWD7. Positions 791-883.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 367737.Abu_2043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV68260 ; ABV68260 ; Abu_2043 .
GeneIDi 5625285.
KEGGi abu:Abu_2043.
PATRICi 20965452. VBIArcBut20197_1990.

Phylogenomic databases

eggNOGi COG0532.
HOGENOMi HOG000076906.
KOi K02519.
OMAi CTIDIDY.
OrthoDBi EOG67HJSV.

Enzyme and pathway databases

BioCyci ABUT367737:GHWO-2041-MONOMER.

Family and domain databases

Gene3Di 3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00100_B. IF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RM4018.

Entry informationi

Entry nameiIF2_ARCB4
AccessioniPrimary (citable) accession number: A8EWD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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