Skip Header

Contribute Send feedback
Read comments (?) or add your own

A8EVQ3 (DCUP_ARCB4) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:Abu_1786
OrganismArcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]
Taxonomic identifier367737 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325623

Regions

Region23 – 275Substrate binding By similarity

Sites

Binding site731Substrate By similarity
Binding site1511Substrate By similarity
Binding site2061Substrate By similarity
Binding site3211Substrate By similarity
Site731Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
A8EVQ3 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: E8C8D1E68408ABA6

FASTA34639,125
        10         20         30         40         50         60 
MSKIFVDACF RKETPYTPVW MMRQAGRYLP EYMEVRAKAG NFLNLCHNPE LAAEVTIQPL 

        70         80         90        100        110        120 
DIVGVDAAIL FSDILVVPNE MGMKLDFLKG EGPVFDKPIK TEADLDALIG GEEAANKLTY 

       130        140        150        160        170        180 
VYETIKILKQ RLPQDKALIG FTGAPWTLAT YMIEGQGTKT YNLCKKMMYS NPEFLHKILR 

       190        200        210        220        230        240 
RVTDVVKFYM EKQIEAGVDV VQIFDSWAAA IEPSKYDEFS WKYMVEIAEY LKEKYPHIPV 

       250        260        270        280        290        300 
IMFPKGIAAF IERGLVYGNF DVFGVDWGTP MALAKEKLGE KYVLQGNMEP CRLYSKEATT 

       310        320        330        340 
MCVEGIQNIM GGNGHIFNLG HGILPDVPVE NAIHFVKECQ RVSKKA

« Hide

References

[1]"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri."
Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E.
PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RM4018.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000361 Genomic DNA. Translation: ABV68026.1.
RefSeqYP_001490696.1. NC_009850.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA8EVQ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5624866.
GenomeReviewsGene locus Abu_1786 in contig CP000361_GR.
KEGGabu:Abu_1786.
PATRIC20964936. VBIArcBut20197_1753.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycABUT367737:ABU_1786-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_ARCB4
AccessionPrimary (citable) accession number: A8EVQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 13, 2007
Last modified: January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents