A8EV89 (AROC_ARCB4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	Abu_1614

Organism

Arcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]

Taxonomic identifier

367737 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Chorismate synthase HAMAP MF_00300		PRO_1000059308

Sequences

	Sequence		Length	Mass (Da)
	A8EV89 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 4A3B1DAA655C9815	FASTA	358	39,240
	10 20 30 40 50 60 MNTFGHRFRF TTFGESHGKA LGCIVDGVPA GIKIDEKFIQ SEMDRRKPGQ NKFATQRKEG 70 80 90 100 110 120 DVVEILSGVF EGMTTGTSIS MIIFNENQKS GDYSNIKDLF RPGHADFTYF NKYGIRDYRG 130 140 150 160 170 180 GGRSSARETA ARVAAGAIAK LLLKELNIDI RSGICEINGI QASNFDFENV KDSEIYALDK 190 200 210 220 230 240 SVEEEQKNAI LEARNSHNSV GGVALVNVKN CPIGLGEPLY FKLDSQIANA MMSINAVKAV 250 260 270 280 290 300 EIGDGILASK VKGYENNDQI RKAGFKTNHT GGILGGISNG DEINVKVYFK ATPSIFIEQE 310 320 330 340 350 TIDIYNNEVN CNLKGRHDPC VAVRGSVVAE SMMALVLADM VLLNLSSKIE NIKKVYEK

References

[1]

"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri." Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E. PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RM4018.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000361 Genomic DNA. Translation: ABV67862.1.
RefSeq	YP_001490532.1. NC_009850.1.
3D structure databases
ProteinModelPortal	A8EV89.
SMR	A8EV89. Positions 1-358.
ModBase	Search...
Protein-protein interaction databases
STRING	A8EV89.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5624627.
GenomeReviews	Gene locus Abu_1614 in contig CP000361_GR.
KEGG	abu:Abu_1614.
PATRIC	20964590. VBIArcBut20197_1586.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0082.
HOGENOM	HBG292336.
OMA	GVQGGIS.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	ABUT367737:ABU_1614-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_ARCB4

Accession

Primary (citable) accession number: A8EV89

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program