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Protein

Catalase-peroxidase

Gene

katG

Organism
Arcobacter butzleri (strain RM4018)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei92 – 921Transition state stabilizerUniRule annotation
Active sitei96 – 961Proton acceptorUniRule annotation
Metal bindingi264 – 2641Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciABUT367737:GHWO-1546-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Abu_1548
OrganismiArcobacter butzleri (strain RM4018)
Taxonomic identifieri367737 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
Proteomesi
  • UP000001136 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 735735Catalase-peroxidasePRO_0000354721Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki95 ↔ 223Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249)UniRule annotation
Cross-linki223 ↔ 249Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-95)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA8EV24.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi367737.Abu_1548.

Structurei

3D structure databases

ProteinModelPortaliA8EV24.
SMRiA8EV24. Positions 20-733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8EV24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKCPMGFG TTNPMVRNGG TSNKDWWPNQ LNLKILSQHS NKVNPLGSDF
60 70 80 90 100
DYAKEFSKLD YDALKADLTA LMTDSQDWWP ADYGHYGPLF IRMAWHSAGT
110 120 130 140 150
YRTGDGRGGA STGSQRLAPL NSWPDNANLD KARRLLWPIK QKYGNKISWA
160 170 180 190 200
DLMILAGNVA LESMGLKTFG FSGGRVDVWE PEEDIYWGKE AQWLATSDKE
210 220 230 240 250
NSRYSGDRDL ENPLAAVQMG LIYVNPEGPD GVPDPIKSGI DIRETFARMA
260 270 280 290 300
MDDEETVALT AGGHTFGKCH GAGDAANVGA EPEAEGLVAQ GLGWLSKFLS
310 320 330 340 350
GKGDDTITSG IEGSWTANPT RWDNEYFDIL LSYDWELTKS PAGAWQWIPK
360 370 380 390 400
NPKEEHLAPA AHDKTKKVTT IMTTADMAMK MDPIYAKISK RFHENPQEFA
410 420 430 440 450
DAFARAWFKL THRDLGPKSK YIGPEIPKED LIWQDPIPPI NYEIIDEKDI
460 470 480 490 500
EILKEKLLSS SLGVSKLVSL AWASASTYRD SDKRGGANGA RIALEPQRSW
510 520 530 540 550
ESNSYLNLDE SLKILETIKG EFNSSNSNKK VSLADLIVLG GCAAVEKAAK
560 570 580 590 600
DAGFNIKVPF TAGRADATQE QTHVESFSHL EPIADGFRNY SKAKYTLSTE
610 620 630 640 650
ELLIDKAQLL SLTIPEMIVL VGGMRVLGAN YANSDLGVFT SNVGVLSNDF
660 670 680 690 700
FVNLLDMKTA WYPTTQEEDS FVGKDRQSGS MKYSASRVDL LFGSNSQLRA
710 720 730
VSEVYAQEDS KEKFVQDFIN AWTKVMNLDR FDIKK
Length:735
Mass (Da):81,448
Last modified:November 13, 2007 - v1
Checksum:i5459DB4B5E9D6BC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000361 Genomic DNA. Translation: ABV67797.1.
RefSeqiWP_012013181.1. NC_009850.1.

Genome annotation databases

EnsemblBacteriaiABV67797; ABV67797; Abu_1548.
GeneIDi24305679.
KEGGiabu:Abu_1548.
PATRICi20964454. VBIArcBut20197_1518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000361 Genomic DNA. Translation: ABV67797.1.
RefSeqiWP_012013181.1. NC_009850.1.

3D structure databases

ProteinModelPortaliA8EV24.
SMRiA8EV24. Positions 20-733.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi367737.Abu_1548.

Proteomic databases

PRIDEiA8EV24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV67797; ABV67797; Abu_1548.
GeneIDi24305679.
KEGGiabu:Abu_1548.
PATRICi20964454. VBIArcBut20197_1518.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciABUT367737:GHWO-1546-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RM4018.

Entry informationi

Entry nameiKATG_ARCB4
AccessioniPrimary (citable) accession number: A8EV24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 13, 2007
Last modified: December 9, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.