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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Arcobacter butzleri (strain RM4018)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei151GTPUniRule annotation1
Binding sitei155GTPUniRule annotation1
Binding sitei199GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 37GTPUniRule annotation5
Nucleotide bindingi120 – 122GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, SeptationUniRule annotation

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotationImported
Ordered Locus Names:Abu_1379Imported
OrganismiArcobacter butzleri (strain RM4018)Imported
Taxonomic identifieri367737 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
Proteomesi
  • UP000001136 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Protein-protein interaction databases

STRINGi367737.Abu_1379.

Structurei

3D structure databases

ProteinModelPortaliA8EUL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 217TubulinInterPro annotationAdd BLAST193
Domaini222 – 341Tubulin_CInterPro annotationAdd BLAST120

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiGMAMMGI.
OrthoDBiPOG091H02KK.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.

Sequencei

Sequence statusi: Complete.

A8EUL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLFREDDI RVDMPSKVLS NNLPKIAVIG VGGGGCNMIN HMIDEGSHKI
60 70 80 90 100
DLIVANTDLK VLHVSKAPKK IELGHKLNNG FGAGMDPEVG RNSALESYEE
110 120 130 140 150
IKETLKGSDI VFVAAGLGGG TGTGAAAIIA KAAREVGALT VSVVTKPFSF
160 170 180 190 200
EGKMRAGLAN LGLEELKKVS DSLIVISNDK LTEIVDASLG IKNAFKIVDN
210 220 230 240 250
ILYQAVNGMS EVILNPGSGA DINADFADVK TIMKHKGIAL MGIGKAKGEE
260 270 280 290 300
ATQRALENAI NSPLLEKVPL DGAKGILIHF TVNPEISLLA ISDIMETVHE
310 320 330 340 350
KVDQNAQIIF GTTTDATFDR DEVKITIIAT GFESKNEEKS DSQDQTEDIE
360 370
SIKIENAETS LDTPPLMRGY TIEYPLN
Length:377
Mass (Da):40,296
Last modified:November 13, 2007 - v1
Checksum:iA8F25BB17B5C88E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000361 Genomic DNA. Translation: ABV67634.1.
RefSeqiWP_012013040.1. NC_009850.1.

Genome annotation databases

EnsemblBacteriaiABV67634; ABV67634; Abu_1379.
GeneIDi24304439.
KEGGiabu:Abu_1379.
PATRICi20964122. VBIArcBut20197_1357.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000361 Genomic DNA. Translation: ABV67634.1.
RefSeqiWP_012013040.1. NC_009850.1.

3D structure databases

ProteinModelPortaliA8EUL0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi367737.Abu_1379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV67634; ABV67634; Abu_1379.
GeneIDi24304439.
KEGGiabu:Abu_1379.
PATRICi20964122. VBIArcBut20197_1357.

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiGMAMMGI.
OrthoDBiPOG091H02KK.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiIPR000158. Cell_div_FtsZ.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PfamiPF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
[Graphical view]
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA8EUL0_ARCB4
AccessioniPrimary (citable) accession number: A8EUL0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.