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A8EUB2

- ASSY_ARCB4

UniProt

A8EUB2 - ASSY_ARCB4

Protein

Argininosuccinate synthase

Gene

argG

Organism
Arcobacter butzleri (strain RM4018)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei92 – 921CitrullineUniRule annotation
    Binding sitei97 – 971CitrullineUniRule annotation
    Binding sitei122 – 1221ATP; via amide nitrogenUniRule annotation
    Binding sitei124 – 1241AspartateUniRule annotation
    Binding sitei128 – 1281AspartateUniRule annotation
    Binding sitei128 – 1281CitrullineUniRule annotation
    Binding sitei129 – 1291AspartateUniRule annotation
    Binding sitei132 – 1321CitrullineUniRule annotation
    Binding sitei189 – 1891CitrullineUniRule annotation
    Binding sitei198 – 1981CitrullineUniRule annotation
    Binding sitei274 – 2741CitrullineUniRule annotation
    Binding sitei286 – 2861CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 209ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciABUT367737:GHWO-1277-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Abu_1279
    OrganismiArcobacter butzleri (strain RM4018)
    Taxonomic identifieri367737 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
    ProteomesiUP000001136: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413Argininosuccinate synthasePRO_0000321300Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi367737.Abu_1279.

    Structurei

    3D structure databases

    ProteinModelPortaliA8EUB2.
    SMRiA8EUB2. Positions 8-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8EUB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKKDIKKVV LAYSGGLDTS IILKWLQDEY NAEVITFTAD LGQGEEVEPA    50
    RQKAIACGIK PENVFILDIK EEFVKDYVFP MFRANAIYEG EYLLGTSIAR 100
    PLIAKKLVEI ANQKGAEAVS HGATGKGNDQ VRFELGALAL NPDLKVIAPW 150
    REWTLNSRES LLEYAKKNGI EISQKHVDEN GNPKISPYSM DANLLHISYE 200
    GLHLENPANE PEESMWLWTN SPEQAPDEAE YITIGYKNGD PISINGKELS 250
    PATLLKTLND YGNKHGIGRV DIVENRYVGM KARGCYETPG GTIMLKAHRA 300
    IESLTLDREA AHLKDELMPR YAKLIYQGYW FSPEREMLQA AIDATQKNVE 350
    GTVRLKLYKG NVTVVGRESS KSLYDDAYST FEKDEVYNQK DAEGFIRLNA 400
    LRFIIAGKKN NKK 413
    Length:413
    Mass (Da):46,373
    Last modified:November 13, 2007 - v1
    Checksum:iE035334064CC2470
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000361 Genomic DNA. Translation: ABV67536.1.
    RefSeqiWP_012012952.1. NC_009850.1.
    YP_001490205.1. NC_009850.1.

    Genome annotation databases

    EnsemblBacteriaiABV67536; ABV67536; Abu_1279.
    GeneIDi5625040.
    KEGGiabu:Abu_1279.
    PATRICi20963924. VBIArcBut20197_1260.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000361 Genomic DNA. Translation: ABV67536.1 .
    RefSeqi WP_012012952.1. NC_009850.1.
    YP_001490205.1. NC_009850.1.

    3D structure databases

    ProteinModelPortali A8EUB2.
    SMRi A8EUB2. Positions 8-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 367737.Abu_1279.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV67536 ; ABV67536 ; Abu_1279 .
    GeneIDi 5625040.
    KEGGi abu:Abu_1279.
    PATRICi 20963924. VBIArcBut20197_1260.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci ABUT367737:GHWO-1277-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RM4018.

    Entry informationi

    Entry nameiASSY_ARCB4
    AccessioniPrimary (citable) accession number: A8EUB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3