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A8EU19

- PNP_ARCB4

UniProt

A8EU19 - PNP_ARCB4

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Abu_1183
Organism
Arcobacter butzleri (strain RM4018)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi506 – 5061Magnesium By similarity
Metal bindingi512 – 5121Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciABUT367737:GHWO-1181-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Abu_1183
OrganismiArcobacter butzleri (strain RM4018)
Taxonomic identifieri367737 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
ProteomesiUP000001136: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329503Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi367737.Abu_1183.

Structurei

3D structure databases

ProteinModelPortaliA8EU19.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini571 – 63161KH
Add
BLAST
Domaini657 – 72468S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8EU19-1 [UniParc]FASTAAdd to Basket

« Hide

MSKVCEFELN GKQEIFEFEK VAKQSNGAVL AKIGNAVVLA TVVSEFDNPV    50
SEDFTPLTVQ YIEKTYAAAK LPGGFIKREG KPSDFETLTS RVIDRSLRPL 100
FPKGYVYPTT ITVMVLSADK NVDLQTLSLN AANAALYTSN LPIKKSVCGV 150
RVGKIENTLV INPTNEQLEN STLDLYVAGS KEELLMIEMK TISSSELVEI 200
DIEAFTKIHN TNEMDEDALV EAIAFAQNAL KEANLTYEKA FEEVSKEKFE 250
VELVKFTIEE SVINYVRDNF SNDIKEAIKK LAKSERATQL KDVAKMISKN 300
EYCISNEIEF NTIYEAVSVV KREIVRAMIV NERVRADGRG LKDVRPISIE 350
TNILPSTHSS CLFTRGETQA LVIGTIAGPK DGQMYEVLTD KSTSMENFMV 400
HYNFPGFSVG EAKPMFGVGR RELGHGNLAK KALEATIDKD YNETVRLVSE 450
ILESNGSSSM ATVCGGSLAL KAAGIPISDL VAGVAMGMVV ENDKYAILTD 500
IMGLEDHDGD MDFKVAGTSK GITALQMDIK LGGIELSVLK EALLQAKEGR 550
THILSLMKDA EKDIVPSGAL PLIEQFAIDP SKIMVVIGKA GATIKEIIEK 600
FTVSIDLDKE NGTVKVSGGN KQNIIDACEH IKTISNNAPS KKDASKNIDF 650
EKLYSEDEVV IGKVERLADF GAFILLPKGG EGLLHISKIS KDRVKNVADV 700
LSIGQELEVK VLKVKKDRIE LSSAN 725
Length:725
Mass (Da):79,350
Last modified:November 13, 2007 - v1
Checksum:i805C35F8C17E7933
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000361 Genomic DNA. Translation: ABV67443.1.
RefSeqiWP_012012877.1. NC_009850.1.
YP_001490112.1. NC_009850.1.

Genome annotation databases

EnsemblBacteriaiABV67443; ABV67443; Abu_1183.
GeneIDi5624774.
KEGGiabu:Abu_1183.
PATRICi20963738. VBIArcBut20197_1170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000361 Genomic DNA. Translation: ABV67443.1 .
RefSeqi WP_012012877.1. NC_009850.1.
YP_001490112.1. NC_009850.1.

3D structure databases

ProteinModelPortali A8EU19.
ModBasei Search...

Protein-protein interaction databases

STRINGi 367737.Abu_1183.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV67443 ; ABV67443 ; Abu_1183 .
GeneIDi 5624774.
KEGGi abu:Abu_1183.
PATRICi 20963738. VBIArcBut20197_1170.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci ABUT367737:GHWO-1181-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RM4018.

Entry informationi

Entry nameiPNP_ARCB4
AccessioniPrimary (citable) accession number: A8EU19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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