A8ET36 (TRPC_ARCB4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	Abu_0850

Organism

Arcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]

Taxonomic identifier

367737 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000057870

Sequences

	Sequence		Length	Mass (Da)
	A8ET36 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 5A763A49CC33C065	FASTA	263	29,886
	10 20 30 40 50 60 MILDEIIEKT KEDLILRKEK LNFEELEKKL KTINSKPKDV KTFLKSTKEE PIRIIAEVKK 70 80 90 100 110 120 ASPSKGIIKE DFNPLEIALE YSQNGANAIS VLTEPHYFKG NLEYLSTIKN SVSTPLLRKD 130 140 150 160 170 180 FIVDKYQIAE ALLYGADFIL LIAKALNEKE LKELYEYARS LDLEVLVEIH DNEDLTKALN 190 200 210 220 230 240 SNATIIGINH RNLGTFEMDM ALCDKLIPLI PKDKIIVAES GVSDTEVIKR LHNVGADAFL 250 260 IGEHFMRVPS IKDELTKFKN TLN

References

[1]

"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri." Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E. PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RM4018.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000361 Genomic DNA. Translation: ABV67110.1.
RefSeq	YP_001489779.1. NC_009850.1.
3D structure databases
ProteinModelPortal	A8ET36.
ModBase	Search...
Protein-protein interaction databases
STRING	A8ET36.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5623458.
GenomeReviews	Gene locus Abu_0850 in contig CP000361_GR.
KEGG	abu:Abu_0850.
PATRIC	20963068. VBIArcBut20197_0835.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
HOGENOM	HBG540956.
OMA	FFPEQVK.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	ABUT367737:ABU_0850-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_ARCB4

Accession

Primary (citable) accession number: A8ET36

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program