Reviewed, UniProtKB/Swiss-Prot A8ESX7 (ALR_ARCB4)

Names and origin

Protein names

Recommended name:
    Alanine racemase
    EC=5.1.1.1

Gene names

Name:	alr
Ordered Locus Names:	Abu_0786

Organism

Arcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]

Taxonomic identifier

367737 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity.
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: HAMAP cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Alanine racemase HAMAP MF_01201		PRO_1000138580
Sites
	Active site	33	1	Proton acceptor; specific for D-alanine By similarity
	Active site	249	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	33	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8ESX7-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 71AAD7F5F06A761E	FASTA	340	38,545
	10 20 30 40 50 60 MAKILLSKEN LFYNLDVISK KAGSKEKVAV VLKDNAYGHG LVEIATLAKE FGIKKAVVRT 70 80 90 100 110 120 IDDALKIEKL FDFILVLAEK SFHTYSHTFH IALNSLEDID KLPNNSNVHI KVDTGMHRNG 130 140 150 160 170 180 IYPEDLEKAF LGLLERNIKV TGVFTHHRGA DELSTDFFWQ KENFSLVKKS VKNICEKLFL 190 200 210 220 230 240 PIPLFHSCNS AALFRTENFD EDFTRVGIAT YGYLDDSDVF NFPKLKPVMS LWASRLSTRI 250 260 270 280 290 300 LKKGQSVGYG GTFTTTEDML VSTYDVGYGD GFLRLNERKS YTTPKGYKVL GRVSMDNLSL 310 320 330 340 NTDDEKVCIF DDVRELAKIH DTITYEITTT LNPNIEKEII

References

[1]

"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri." Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E. PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000361 Genomic DNA. Translation: ABV67051.1.
RefSeq	YP_001489720.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8ESX7.
Genome annotation databases
GeneID	5624141.
GenomeReviews	Gene locus Abu_0786 in contig CP000361_GR.
KEGG	abu:Abu_0786.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	GHETISA.
Family and domain databases
HAMAP	MF_01201. [Tree]
InterPro	IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR000821. Ala_racemase_reg. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR_ARCB4

Accession

Primary (citable) accession number: A8ESX7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 13, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)