A8ESX1 (A8ESX1_ARCB4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenylate kinase 2 HAMAP MF_00235
Short name=AK 2 HAMAP MF_00235
EC=2.7.4.3 HAMAP MF_00235

Alternative name(s):
ATP-AMP transphosphorylase 2 HAMAP MF_00235

Gene names

Name:	adk2 HAMAP MF_00235 EMBL ABV67045.1
Ordered Locus Names:	Abu_0780

Organism

Arcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]

Taxonomic identifier

367737 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth By similarity. HAMAP MF_00235
Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00235 RuleBase RU003331
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP MF_00235
Subunit structure	Monomer By similarity. HAMAP MF_00235 RuleBase RU003331
Subcellular location	Cytoplasm By similarity HAMAP MF_00235 RuleBase RU003331.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, AMP binding and LID. The LID domain closes over the site of phosphoryl transfer upon ATP binding By similarity. HAMAP MF_00235
Sequence similarities	Belongs to the adenylate kinase family. HAMAP MF_00235 RuleBase RU003330

Ontologies

Keywords
Biological process	Nucleotide biosynthesis HAMAP MF_00235
Cellular component	Cytoplasm HAMAP MF_00235
Ligand	ATP-binding HAMAP MF_00235 RuleBase RU003331 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00235 RuleBase RU003330 EMBL ABV67045.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity HAMAP MF_00235
	Nucleotide binding	34 – 62	29	AMP By similarity HAMAP MF_00235

Sequences

	Sequence		Length	Mass (Da)
	A8ESX1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 5F67905557D3EA0D	FASTA	189	21,233
	10 20 30 40 50 60 MKKLFLIIGA PGSGKTTDAE LIASKYTNVT HYSTGDMFRA EVASGSQRGQ IIDTYIKAGN 70 80 90 100 110 120 IVPIDIAIET ILMAIKNAPT DIIVIDGYPR SIEQMLELDK YLEKEDAVKL LNCIEVEVSE 130 140 150 160 170 180 EVARDRVLGR SRGADDNIEV FNNRMKVYKE PLEQIKEFYS KRGLLKIING EGTIKEIVDE MDTFIQSRI

References

[1]

"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri." Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E. PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000361 Genomic DNA. Translation: ABV67045.1.
RefSeq	YP_001489714.1. NC_009850.1.
3D structure databases
ProteinModelPortal	A8ESX1.
ModBase	Search...
Protein-protein interaction databases
STRING	A8ESX1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5624903.
GenomeReviews	Gene locus Abu_0780 in contig CP000361_GR.
KEGG	abu:Abu_0780.
PATRIC	20962928. VBIArcBut20197_0769.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0563.
HOGENOM	HBG630208.
OMA	EMQKYIL.
ProtClustDB	PRK00279.
Family and domain databases
HAMAP	MF_00235. Adenylate_kinase_Adk. [Tree]
InterPro	IPR000850. Adenylate_kin. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8ESX1_ARCB4

Accession

Primary (citable) accession number: A8ESX1

Entry history

Integrated into UniProtKB/TrEMBL:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)