Reviewed, UniProtKB/Swiss-Prot A8ESF7 (ARLY_ARCB4)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Abu_0616

Organism

Arcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]

Taxonomic identifier

367737 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Argininosuccinate lyase HAMAP MF_00006		PRO_0000321428

Sequences

	Sequence		Length	Mass (Da)
	A8ESF7-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 39894DCA14309DDF	FASTA	466	52,817
	10 20 30 40 50 60 MSNQNNQNNQ ILKNTNAQIL DEFNASIMFD KELYAQDIKG SIAHSKMLAS QGILTNEEQK 70 80 90 100 110 120 AIEKGLFQVK SEIESGEFKF SLAYEDIHMA VETRLTEIIG EPGKKLHTAR SRNDQVCTDF 130 140 150 160 170 180 TLYVQDKTLS IKEQLKELVA TFVDIASLHT TTLIPGMTHL QHAQPLNFGF HLLAYANMFK 190 200 210 220 230 240 RDYERFESSF ERNNYSPLGS AALAGTPHNI NRELTAQTLG FTAPTLNAMD TVSNRDFALE 250 260 270 280 290 300 ILFNISTTMM HISRISEELI LWSSYEFQFV RMSDQYATTS SIMPQKKNPD VPELLRGKTG 310 320 330 340 350 360 RVYGNLISLL TVMKGLPLAY NKDTQEDKEG VFDSVKTVEI SISILNEVIK TMIVNVDKMQ 370 380 390 400 410 420 NACKIGHLTA TDLADYLVQK QNMPFRTAYY ITKDVVALAN SLNKDISELS IDEIRKANDE 430 440 450 460 LKNINEDIVL YLDLKNSMNA RNSFGGTSTK QTESQIEYFK KWLENK

References

[1]

"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri." Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E. PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000361 Genomic DNA. Translation: ABV66881.1.
RefSeq	YP_001489550.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8ESF7.
Genome annotation databases
GeneID	5623098.
GenomeReviews	Gene locus Abu_0616 in contig CP000361_GR.
KEGG	abu:Abu_0616.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ATDTRLY.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ARCB4

Accession

Primary (citable) accession number: A8ESF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 13, 2007
Last modified:	November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)