Reviewed, UniProtKB/Swiss-Prot A8ESC9 (NTPA_ARCB4)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

Abu_0586

Organism

Arcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]

Taxonomic identifier

367737 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Nucleoside-triphosphatase		PRO_1000068409

Sequences

	Sequence		Length	Mass (Da)
	A8ESC9-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 8B1A3899903F6195	FASTA	199	22,058
	10 20 30 40 50 60 MKIVLASANK GKIKEFERLL PNDEIVAFSE ILGKIEIDED KDTFKGNAIK KAQTIYDELQ 70 80 90 100 110 120 KINFGDVVVI SDDSGISVPV LGNAPGVYSA RYAGLNASDK ENNEKLKAEL NKLGLEKTPA 130 140 150 160 170 180 FYTACIAIVY KNEVYTVHGW MYGEVLNKEI GTNGFGYDPM FIPNGYDKTL GELDEGVKKE 190 FSHRSKALKL AMKVLEVIL

References

[1]

"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri." Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E. PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000361 Genomic DNA. Translation: ABV66853.1.
RefSeq	YP_001489522.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5623750.
GenomeReviews	Gene locus Abu_0586 in contig CP000361_GR.
KEGG	abu:Abu_0586.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NTPA_ARCB4

Accession

Primary (citable) accession number: A8ESC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	September 2, 2008
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)