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A8ERV3

- SYL_ARCB4

UniProt

A8ERV3 - SYL_ARCB4

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Protein
Leucine--tRNA ligase
Gene
leuS, Abu_0402
Organism
Arcobacter butzleri (strain RM4018)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei589 – 5891ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciABUT367737:GHWO-401-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Abu_0402
OrganismiArcobacter butzleri (strain RM4018)
Taxonomic identifieri367737 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
ProteomesiUP000001136: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 821821Leucine--tRNA ligaseUniRule annotation
PRO_1000057341Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi367737.Abu_0402.

Structurei

3D structure databases

ProteinModelPortaliA8ERV3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionUniRule annotation
Add
BLAST
Motifi586 – 5905"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8ERV3-1 [UniParc]FASTAAdd to Basket

« Hide

MEYISKDIEK KWQNFWSENQ SFEPSSSKTK EKKYILSMFP YPSGRIHMGH    50
VRNYCIGDAF ARHFRKSDFN VLHPIGWDSF GMPAENAAIK HKLHPKKWTY 100
ENIDYMRDEL KSLGLSFSKN REFATSDELY TKWEQEFIIK MYEAGIIYRK 150
SATVNWCPHD QTVLANEQLE EGCCWRCGTE VVQKEMPGYY IGITKYAQEL 200
LDDLEKLKED WPSQVLTMQE NWIGRSEGLE FKFDLSKESR AKLERAFTKY 250
FVFTTRPDTI YGVSYSALAP EHPIVKYIVE KNLLPEKKIK AIKAMQKIPE 300
RDRATQEKEG IDLEIEVMHP LTGKTIPVWV ANFVLSSYGG GAVMAVPAHD 350
QRDFEFAKKY NLPIKQVIVG PDGIIENQTE AYTAEGRLIE SENFTGVTNI 400
EAKKAIIYHF EQNSFGIKKV NYKLRDWGVS RQRYWGAPIP FIHCEKCGLV 450
PEKIENLPVA LPEDVEITGE GNPLDTHPTW KHCTCPKCGE KATRETDTLD 500
TFVQSSWYFL RYATDNKKWN EVGISKEDSD YWMDVDQYIG GIEHAILHLL 550
YARFFTKVLR DLGYTNSSEP FKKLLTQGMV LKDGAKMSKS KGNVVDPDLI 600
IDKYGADTAR LFILFAAPPT KELEWNDSAV EGAFRFIKKF FERAENVNQN 650
GLDNFKSIDH SALSKEEKEA RKKVYEALLK SNEVFTKTYT FNTLIASCME 700
ALNALQTQKN DSIWAEGYYI LTNILEPIIP HACWELSKKL FDLKNFDGKI 750
ELKEEVFALE SIILAVTVNG KKRCEIEVAP DTSKDEILVK AKIASAKWLE 800
NSEILKEIVV PNKLVNFVIK G 821
Length:821
Mass (Da):94,469
Last modified:November 13, 2007 - v1
Checksum:iC1F899A1C28CB234
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000361 Genomic DNA. Translation: ABV66677.1.
RefSeqiYP_001489346.1. NC_009850.1.

Genome annotation databases

EnsemblBacteriaiABV66677; ABV66677; Abu_0402.
GeneIDi5624639.
KEGGiabu:Abu_0402.
PATRICi20962162. VBIArcBut20197_0394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000361 Genomic DNA. Translation: ABV66677.1 .
RefSeqi YP_001489346.1. NC_009850.1.

3D structure databases

ProteinModelPortali A8ERV3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 367737.Abu_0402.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABV66677 ; ABV66677 ; Abu_0402 .
GeneIDi 5624639.
KEGGi abu:Abu_0402.
PATRICi 20962162. VBIArcBut20197_0394.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ABUT367737:GHWO-401-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RM4018.

Entry informationi

Entry nameiSYL_ARCB4
AccessioniPrimary (citable) accession number: A8ERV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 13, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi