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A8ERV3

- SYL_ARCB4

UniProt

A8ERV3 - SYL_ARCB4

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Arcobacter butzleri (strain RM4018)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei589 – 5891ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciABUT367737:GHWO-401-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Abu_0402
    OrganismiArcobacter butzleri (strain RM4018)
    Taxonomic identifieri367737 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeArcobacter
    ProteomesiUP000001136: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 821821Leucine--tRNA ligasePRO_1000057341Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi367737.Abu_0402.

    Structurei

    3D structure databases

    ProteinModelPortaliA8ERV3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi586 – 5905"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8ERV3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYISKDIEK KWQNFWSENQ SFEPSSSKTK EKKYILSMFP YPSGRIHMGH    50
    VRNYCIGDAF ARHFRKSDFN VLHPIGWDSF GMPAENAAIK HKLHPKKWTY 100
    ENIDYMRDEL KSLGLSFSKN REFATSDELY TKWEQEFIIK MYEAGIIYRK 150
    SATVNWCPHD QTVLANEQLE EGCCWRCGTE VVQKEMPGYY IGITKYAQEL 200
    LDDLEKLKED WPSQVLTMQE NWIGRSEGLE FKFDLSKESR AKLERAFTKY 250
    FVFTTRPDTI YGVSYSALAP EHPIVKYIVE KNLLPEKKIK AIKAMQKIPE 300
    RDRATQEKEG IDLEIEVMHP LTGKTIPVWV ANFVLSSYGG GAVMAVPAHD 350
    QRDFEFAKKY NLPIKQVIVG PDGIIENQTE AYTAEGRLIE SENFTGVTNI 400
    EAKKAIIYHF EQNSFGIKKV NYKLRDWGVS RQRYWGAPIP FIHCEKCGLV 450
    PEKIENLPVA LPEDVEITGE GNPLDTHPTW KHCTCPKCGE KATRETDTLD 500
    TFVQSSWYFL RYATDNKKWN EVGISKEDSD YWMDVDQYIG GIEHAILHLL 550
    YARFFTKVLR DLGYTNSSEP FKKLLTQGMV LKDGAKMSKS KGNVVDPDLI 600
    IDKYGADTAR LFILFAAPPT KELEWNDSAV EGAFRFIKKF FERAENVNQN 650
    GLDNFKSIDH SALSKEEKEA RKKVYEALLK SNEVFTKTYT FNTLIASCME 700
    ALNALQTQKN DSIWAEGYYI LTNILEPIIP HACWELSKKL FDLKNFDGKI 750
    ELKEEVFALE SIILAVTVNG KKRCEIEVAP DTSKDEILVK AKIASAKWLE 800
    NSEILKEIVV PNKLVNFVIK G 821
    Length:821
    Mass (Da):94,469
    Last modified:November 13, 2007 - v1
    Checksum:iC1F899A1C28CB234
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000361 Genomic DNA. Translation: ABV66677.1.
    RefSeqiYP_001489346.1. NC_009850.1.

    Genome annotation databases

    EnsemblBacteriaiABV66677; ABV66677; Abu_0402.
    GeneIDi5624639.
    KEGGiabu:Abu_0402.
    PATRICi20962162. VBIArcBut20197_0394.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000361 Genomic DNA. Translation: ABV66677.1 .
    RefSeqi YP_001489346.1. NC_009850.1.

    3D structure databases

    ProteinModelPortali A8ERV3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 367737.Abu_0402.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABV66677 ; ABV66677 ; Abu_0402 .
    GeneIDi 5624639.
    KEGGi abu:Abu_0402.
    PATRICi 20962162. VBIArcBut20197_0394.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci ABUT367737:GHWO-401-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RM4018.

    Entry informationi

    Entry nameiSYL_ARCB4
    AccessioniPrimary (citable) accession number: A8ERV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3