Reviewed, UniProtKB/Swiss-Prot A8ERG2 (PYRB_ARCB4)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	Abu_0261

Organism

Arcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]

Taxonomic identifier

367737 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_1000057008

Sequences

	Sequence		Length	Mass (Da)
	A8ERG2-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 0C623460192C91EB	FASTA	295	33,236
	10 20 30 40 50 60 MQHLIRTSDF TKEEILDIFE DARGFLDFKP CEILKGKIIV TLFFENSTRT RSSFEIAAKR 70 80 90 100 110 120 LGAEIVNLDV GTSSTKKGET MYDTVANINA MGPDAIVIRH SECGLPESLI GYVDCPIINA 130 140 150 160 170 180 GDGRHSHPTQ ALLDLFTIYE HFNGQTEGKK IAIVGDVRNS RVAGSNRRLL PRFGIDVNLV 190 200 210 220 230 240 APDCFKYEGN EFKQFNTIAE VIDDMDVVMS LRSQLERHNI TYFESLQEYA KDFCITPELM 250 260 270 280 290 EGRDFLLLHP GPVNRNIDIS DEVLKDPRCK VLEQVRNGVA VRAAILKKLI LNNKN

References

[1]

"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri." Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E. PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000361 Genomic DNA. Translation: ABV66536.1.
RefSeq	YP_001489205.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5624951.
GenomeReviews	Gene locus Abu_0261 in contig CP000361_GR.
KEGG	abu:Abu_0261.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A8ERG2. YFAGPEE.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_ARCB4

Accession

Primary (citable) accession number: A8ERG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 13, 2007
Last modified:	June 16, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)