Reviewed, UniProtKB/Swiss-Prot A8ERB8 (PANC_ARCB4)

Names and origin

Protein names

Recommended name:
    Pantothenate synthetase
      Short name=PS
    EC=6.3.2.1
Alternative name(s):
    Pantoate--beta-alanine ligase
    Pantoate-activating enzyme

Gene names

Name:	panC
Ordered Locus Names:	Abu_0215

Organism

Arcobacter butzleri (strain RM4018) [Complete proteome] [HAMAP]

Taxonomic identifier

367737 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.
Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP MF_00158
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP MF_00158
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential.
Miscellaneous	The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.
Sequence similarities	Belongs to the pantothenate synthetase family.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pantothenate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Pantothenate synthetase HAMAP MF_00158		PRO_1000076837
Regions
	Nucleotide binding	27 – 34	8	ATP By similarity
	Nucleotide binding	143 – 146	4	ATP By similarity
	Nucleotide binding	180 – 183	4	ATP By similarity
Sites
	Active site	34	1	Proton donor By similarity
	Binding site	58	1	Beta-alanine By similarity
	Binding site	58	1	Pantoate By similarity
	Binding site	149	1	Pantoate By similarity
	Binding site	172	1	ATP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	A8ERB8-1 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 27DF86B08536B23E	FASTA	272	30,807
	10 20 30 40 50 60 MQVLKTIEEL QNIRKNSLGK VGLVPTMGAL HNGHISLIKQ ARNENDIVIV SIFVNPTQFL 70 80 90 100 110 120 PGEDLDAYPR RDEADKKICQ MCKVNYVFMP EISTMYTKEE VLVKAPNKSY ILEGKTRPGH 130 140 150 160 170 180 FDGVLQVVLK LFNLTQPTNA YFGKKDAQQL TLIQQMVKNF FLPINIVPCD IVREEDGLAL 190 200 210 220 230 240 SSRNIYLNPT QRKDALLISK SLYMAGSLIS SGERSVKAVK DKIYEVMSIL DVEYVAIVDK 250 260 270 EFNELETIEP TNTIILVVAR FGNTRLLDNI WL

References

[1]

"The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri." Miller W.G., Parker C.T., Rubenfield M., Mendz G.L., Woesten M.M.S.M., Ussery D.W., Stolz J.F., Binnewies T.T., Hallin P.F., Wang G., Malek J.A., Rogosin A., Stanker L.H., Mandrell R.E. PLoS ONE 2:E1358-E1358(2007) [PubMed: 18159241] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000361 Genomic DNA. Translation: ABV66492.1.
RefSeq	YP_001489161.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A8ERB8.
Genome annotation databases
GeneID	5623748.
GenomeReviews	Gene locus Abu_0215 in contig CP000361_GR.
KEGG	abu:Abu_0215.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ASSKENH.
Family and domain databases
HAMAP	MF_00158. [Tree]
InterPro	IPR004821. Cyt_trans_rel. IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR21299:SF1. Pantoate_ligase. 1 hit.
Pfam	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00125. cyt_tran_rel. 1 hit. TIGR00018. panC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANC_ARCB4

Accession

Primary (citable) accession number: A8ERB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 13, 2007
Last modified:	November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)