UniProtKB - A8EQW9 (SYE1_ARCB4)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Glutamate--tRNA ligase 1
Gene
gltX1
Organism
Arcobacter butzleri (strain RM4018)
Status
Functioni
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation
Catalytic activityi
ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 243 | ATPUniRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- glutamate-tRNA ligase activity Source: UniProtKB-EC
- tRNA binding Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- glutamyl-tRNA aminoacylation Source: InterPro
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | ABUT367737:G1G6I-58-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate--tRNA ligase 1UniRule annotation (EC:6.1.1.17UniRule annotation)Alternative name(s): Glutamyl-tRNA synthetase 1UniRule annotation Short name: GluRS 1UniRule annotation |
Gene namesi | Name:gltX1UniRule annotation Ordered Locus Names:Abu_0058 |
Organismi | Arcobacter butzleri (strain RM4018) |
Taxonomic identifieri | 367737 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Arcobacter › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000330951 | 1 – 469 | Glutamate--tRNA ligase 1Add BLAST | 469 |
Interactioni
Subunit structurei
Monomer.UniRule annotation
Protein-protein interaction databases
STRINGi | 367737.Abu_0058. |
Structurei
3D structure databases
ProteinModelPortali | A8EQW9. |
SMRi | A8EQW9. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 8 – 18 | "HIGH" regionUniRule annotationAdd BLAST | 11 | |
Motifi | 240 – 244 | "KMSKS" regionUniRule annotation | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105C20. Bacteria. COG0008. LUCA. |
HOGENOMi | HOG000252722. |
KOi | K01885. |
OMAi | AYYAFDT. |
OrthoDBi | POG091H021W. |
Family and domain databases
CDDi | cd00808. GluRS_core. 1 hit. |
Gene3Di | 1.10.10.350. 1 hit. 3.40.50.620. 1 hit. |
HAMAPi | MF_00022. Glu_tRNA_synth_type1. 1 hit. |
InterProi | View protein in InterPro IPR008925. aa-tRNA-synth_I_codon-bd. IPR020751. aa-tRNA-synth_I_codon-bd_sub2. IPR001412. aa-tRNA-synth_I_CS. IPR004527. Glu-tRNA-ligase_bac/mito. IPR000924. Glu/Gln-tRNA-synth. IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom. IPR033910. GluRS_core. IPR014729. Rossmann-like_a/b/a_fold. |
Pfami | View protein in Pfam PF00749. tRNA-synt_1c. 1 hit. |
PRINTSi | PR00987. TRNASYNTHGLU. |
SUPFAMi | SSF48163. SSF48163. 1 hit. |
TIGRFAMsi | TIGR00464. gltX_bact. 1 hit. |
PROSITEi | View protein in PROSITE PS00178. AA_TRNA_LIGASE_I. 1 hit. |
i Sequence
Sequence statusi: Complete.
A8EQW9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAITRFAPSP TGYLHIGGLR TSLYSYLWAR KTGGEFRLRI EDTDLARNSE
60 70 80 90 100
EAMKAIIDAF DWVGLNYDGE VFYQSKRTDI YKQYIDKLLE SGNAYKCYMS
110 120 130 140 150
KEELDALRAA QEAAKQTPRY DGTWRPEPGK ELPPVPAGVE PVIRIKAPTT
160 170 180 190 200
GTIEFDDGVK GHMKFDANQV DDYVIARSNG MPTYNFVVAI DDALMGMTDV
210 220 230 240 250
IRGDDHLSNT PKQIVVYNAL GFKVPKFYHV PMINNPEGKK LSKRDGAMDV
260 270 280 290 300
MDYKRLGYLP EALLNFLVRL GWSNGDQEIF SMKEMLELFD PSNINKSASS
310 320 330 340 350
YNGEKLLWLN SEYIKAVSNE RLIEELKFFD LDLSNYPKKN EILDLAKQRA
360 370 380 390 400
QTLVELKKSI TDIIDIPTSY EESGVKKFIK EDTKELLEKY LLLLESNKNS
410 420 430 440 450
LDSVEKIEEF TKPFINDNGL KFPQLFQPIR IALTGGTQAP SVYDIIFILG
460
YDEIFKRINE ALKRNFQNT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000361 Genomic DNA. Translation: ABV66343.1. |
RefSeqi | WP_012011968.1. NC_009850.1. |
Genome annotation databases
EnsemblBacteriai | ABV66343; ABV66343; Abu_0058. |
GeneIDi | 24304370. |
KEGGi | abu:Abu_0058. |
Similar proteinsi
Entry informationi
Entry namei | SYE1_ARCB4 | |
Accessioni | A8EQW9Primary (citable) accession number: A8EQW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 28, 2018 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |