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A8E7N9

- GDF6B_DANRE

UniProt

A8E7N9 - GDF6B_DANRE

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Protein

Growth/differentiation factor 6-B

Gene

gdf6b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. growth Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 6-B
Short name:
GDF-6-B
Alternative name(s):
Growth differentiation factor 6b
Protein dynamo
Gene namesi
Name:gdf6bImported
Synonyms:dynamoImported
ORF Names:si:ch211-244a23.2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-980526-442. gdf6b.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 287266Sequence AnalysisPRO_0000342705Add
BLAST
Chaini293 – 412120Growth/differentiation factor 6-BSequence AnalysisPRO_5000146904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi311 ↔ 377By similarity
Disulfide bondi340 ↔ 409By similarity
Disulfide bondi344 ↔ 411By similarity
Disulfide bondi376 – 376InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expression is correlated temporally and spatially with somitogenesis. At late gastrula stage, expressed in the posterior presumptive neural plate. During somitogenesis, expression becomes restricted along the dorsoventral axis of the trunk neural tube in an anterior-to-posterior progression so that upon completion of somitogenesis, expression is seen exclusively in the ventral spinal cord with the exclusion of the floor plate and adjacent neural cells.1 Publication

Inductioni

By shh.1 Publication

Gene expression databases

BgeeiA8E7N9.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Structurei

3D structure databases

ProteinModelPortaliA8E7N9.
SMRiA8E7N9. Positions 308-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Sequence Analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG249531.
HOGENOMiHOG000231514.
HOVERGENiHBG107938.
InParanoidiA8E7N9.
OMAiILVVFTR.
PhylomeDBiA8E7N9.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8E7N9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCACGILLTF TLLLHFLGVH SMNPLFPSAS RGMKVSKSVP AEGNRRAKYG
60 70 80 90 100
KNVLSASLLS GDIQSRRAIK DAIEPHDYMI SIYKTFSAAE KLGLNASFFR
110 120 130 140 150
SSKAANTITS FVDEGQDDHL NSPLWRQKYL FDVSTLSENV EILGAELRIY
160 170 180 190 200
TKISGSFRAS ETGPVEIQLL SCQSHTVLDS QTLDLEDAHK PKWEVFDVWE
210 220 230 240 250
IFKERQHHSH GTRFCLELRA TLDNPEREID LQYLGFHRHG RPQLKKAILV
260 270 280 290 300
VFTRSKKRQS LFYEKREKIK LWGLDSIGKE RRSHSKTRRS RRTALPNRHG
310 320 330 340 350
KRHGKKSKSR CSKKPLHVNF RELGWDDWVI APLDYEAYHC EGMCDFPLRS
360 370 380 390 400
HLEPTNHAII QTLMNSMNPS NMPPSCCVPS KLSPISILYI DAGNNVVYKQ
410
YEDMVVESCG CR
Length:412
Mass (Da):47,068
Last modified:November 13, 2007 - v1
Checksum:i984B6CE085B0001B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201H → Q in CAA68102. (PubMed:9076689)Curated
Sequence conflicti212 – 2121T → N in CAA68102. (PubMed:9076689)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99769 mRNA. Translation: CAA68102.1.
BX649562, BX571825 Genomic DNA. Translation: CAP09513.1.
BX571825, BX649562 Genomic DNA. Translation: CAP09561.1.
RefSeqiNP_571062.1. NM_130987.1.
UniGeneiDr.75756.

Genome annotation databases

GeneIDi30180.
KEGGidre:30180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99769 mRNA. Translation: CAA68102.1 .
BX649562 , BX571825 Genomic DNA. Translation: CAP09513.1 .
BX571825 , BX649562 Genomic DNA. Translation: CAP09561.1 .
RefSeqi NP_571062.1. NM_130987.1.
UniGenei Dr.75756.

3D structure databases

ProteinModelPortali A8E7N9.
SMRi A8E7N9. Positions 308-412.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 30180.
KEGGi dre:30180.

Organism-specific databases

CTDi 30180.
ZFINi ZDB-GENE-980526-442. gdf6b.

Phylogenomic databases

eggNOGi NOG249531.
HOGENOMi HOG000231514.
HOVERGENi HBG107938.
InParanoidi A8E7N9.
OMAi ILVVFTR.
PhylomeDBi A8E7N9.
TreeFami TF316134.

Miscellaneous databases

NextBioi 20806648.

Gene expression databases

Bgeei A8E7N9.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00669. INHIBINA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dynamo, a new zebrafish DVR member of the TGF-beta superfamily is expressed in the posterior neural tube and is up-regulated by Sonic hedgehog."
    Bruneau S., Rosa F.M.
    Mech. Dev. 61:199-212(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Tissue: EmbryoImported.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.

Entry informationi

Entry nameiGDF6B_DANRE
AccessioniPrimary (citable) accession number: A8E7N9
Secondary accession number(s): O12938
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3