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A8E7N9

- GDF6B_DANRE

UniProt

A8E7N9 - GDF6B_DANRE

Protein

Growth/differentiation factor 6-B

Gene

gdf6b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. growth Source: InterPro

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth/differentiation factor 6-B
    Short name:
    GDF-6-B
    Alternative name(s):
    Growth differentiation factor 6b
    Protein dynamo
    Gene namesi
    Name:gdf6bImported
    Synonyms:dynamoImported
    ORF Names:si:ch211-244a23.2
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 19

    Organism-specific databases

    ZFINiZDB-GENE-980526-442. gdf6b.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 287266Sequence AnalysisPRO_0000342705Add
    BLAST
    Chaini293 – 412120Growth/differentiation factor 6-BSequence AnalysisPRO_5000146904Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi311 ↔ 377By similarity
    Disulfide bondi340 ↔ 409By similarity
    Disulfide bondi344 ↔ 411By similarity
    Disulfide bondi376 – 376InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Expression is correlated temporally and spatially with somitogenesis. At late gastrula stage, expressed in the posterior presumptive neural plate. During somitogenesis, expression becomes restricted along the dorsoventral axis of the trunk neural tube in an anterior-to-posterior progression so that upon completion of somitogenesis, expression is seen exclusively in the ventral spinal cord with the exclusion of the floor plate and adjacent neural cells.1 Publication

    Inductioni

    By shh.1 Publication

    Gene expression databases

    BgeeiA8E7N9.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA8E7N9.
    SMRiA8E7N9. Positions 308-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Sequence Analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG249531.
    HOGENOMiHOG000231514.
    HOVERGENiHBG107938.
    InParanoidiO12938.
    OMAiILVVFTR.
    PhylomeDBiA8E7N9.
    TreeFamiTF316134.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A8E7N9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCACGILLTF TLLLHFLGVH SMNPLFPSAS RGMKVSKSVP AEGNRRAKYG    50
    KNVLSASLLS GDIQSRRAIK DAIEPHDYMI SIYKTFSAAE KLGLNASFFR 100
    SSKAANTITS FVDEGQDDHL NSPLWRQKYL FDVSTLSENV EILGAELRIY 150
    TKISGSFRAS ETGPVEIQLL SCQSHTVLDS QTLDLEDAHK PKWEVFDVWE 200
    IFKERQHHSH GTRFCLELRA TLDNPEREID LQYLGFHRHG RPQLKKAILV 250
    VFTRSKKRQS LFYEKREKIK LWGLDSIGKE RRSHSKTRRS RRTALPNRHG 300
    KRHGKKSKSR CSKKPLHVNF RELGWDDWVI APLDYEAYHC EGMCDFPLRS 350
    HLEPTNHAII QTLMNSMNPS NMPPSCCVPS KLSPISILYI DAGNNVVYKQ 400
    YEDMVVESCG CR 412
    Length:412
    Mass (Da):47,068
    Last modified:November 13, 2007 - v1
    Checksum:i984B6CE085B0001B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201H → Q in CAA68102. (PubMed:9076689)Curated
    Sequence conflicti212 – 2121T → N in CAA68102. (PubMed:9076689)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99769 mRNA. Translation: CAA68102.1.
    BX649562, BX571825 Genomic DNA. Translation: CAP09513.1.
    BX571825, BX649562 Genomic DNA. Translation: CAP09561.1.
    RefSeqiNP_571062.1. NM_130987.1.
    UniGeneiDr.75756.

    Genome annotation databases

    GeneIDi30180.
    KEGGidre:30180.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99769 mRNA. Translation: CAA68102.1 .
    BX649562 , BX571825 Genomic DNA. Translation: CAP09513.1 .
    BX571825 , BX649562 Genomic DNA. Translation: CAP09561.1 .
    RefSeqi NP_571062.1. NM_130987.1.
    UniGenei Dr.75756.

    3D structure databases

    ProteinModelPortali A8E7N9.
    SMRi A8E7N9. Positions 308-412.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 30180.
    KEGGi dre:30180.

    Organism-specific databases

    CTDi 30180.
    ZFINi ZDB-GENE-980526-442. gdf6b.

    Phylogenomic databases

    eggNOGi NOG249531.
    HOGENOMi HOG000231514.
    HOVERGENi HBG107938.
    InParanoidi O12938.
    OMAi ILVVFTR.
    PhylomeDBi A8E7N9.
    TreeFami TF316134.

    Miscellaneous databases

    NextBioi 20806648.

    Gene expression databases

    Bgeei A8E7N9.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dynamo, a new zebrafish DVR member of the TGF-beta superfamily is expressed in the posterior neural tube and is up-regulated by Sonic hedgehog."
      Bruneau S., Rosa F.M.
      Mech. Dev. 61:199-212(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
      Tissue: EmbryoImported.
    2. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.

    Entry informationi

    Entry nameiGDF6B_DANRE
    AccessioniPrimary (citable) accession number: A8E7N9
    Secondary accession number(s): O12938
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3