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A8E7N9

- GDF6B_DANRE

UniProt

A8E7N9 - GDF6B_DANRE

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Protein
Growth/differentiation factor 6-B
Gene
gdf6b, dynamo, si:ch211-244a23.2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. growth Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 6-B
Short name:
GDF-6-B
Alternative name(s):
Growth differentiation factor 6b
Protein dynamo
Gene namesi
Name:gdf6b
Synonyms:dynamo
ORF Names:si:ch211-244a23.2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-980526-442. gdf6b.

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Propeptidei22 – 287266 Reviewed prediction
PRO_0000342705Add
BLAST
Chaini293 – 412120Growth/differentiation factor 6-B
PRO_5000146904Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi311 ↔ 377 By similarityBy similarity
Disulfide bondi340 ↔ 409 By similarityBy similarity
Disulfide bondi344 ↔ 411 By similarityBy similarity
Disulfide bondi376 – 376Interchain By similarityBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expression is correlated temporally and spatially with somitogenesis. At late gastrula stage, expressed in the posterior presumptive neural plate. During somitogenesis, expression becomes restricted along the dorsoventral axis of the trunk neural tube in an anterior-to-posterior progression so that upon completion of somitogenesis, expression is seen exclusively in the ventral spinal cord with the exclusion of the floor plate and adjacent neural cells.1 Publication

Inductioni

By shh.1 Publication

Gene expression databases

BgeeiA8E7N9.

Interactioni

Subunit structurei

Homodimer; disulfide-linked By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliA8E7N9.
SMRiA8E7N9. Positions 308-412.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG249531.
HOGENOMiHOG000231514.
HOVERGENiHBG107938.
InParanoidiO12938.
OMAiILVVFTR.
PhylomeDBiA8E7N9.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8E7N9-1 [UniParc]FASTAAdd to Basket

« Hide

MCACGILLTF TLLLHFLGVH SMNPLFPSAS RGMKVSKSVP AEGNRRAKYG    50
KNVLSASLLS GDIQSRRAIK DAIEPHDYMI SIYKTFSAAE KLGLNASFFR 100
SSKAANTITS FVDEGQDDHL NSPLWRQKYL FDVSTLSENV EILGAELRIY 150
TKISGSFRAS ETGPVEIQLL SCQSHTVLDS QTLDLEDAHK PKWEVFDVWE 200
IFKERQHHSH GTRFCLELRA TLDNPEREID LQYLGFHRHG RPQLKKAILV 250
VFTRSKKRQS LFYEKREKIK LWGLDSIGKE RRSHSKTRRS RRTALPNRHG 300
KRHGKKSKSR CSKKPLHVNF RELGWDDWVI APLDYEAYHC EGMCDFPLRS 350
HLEPTNHAII QTLMNSMNPS NMPPSCCVPS KLSPISILYI DAGNNVVYKQ 400
YEDMVVESCG CR 412
Length:412
Mass (Da):47,068
Last modified:November 13, 2007 - v1
Checksum:i984B6CE085B0001B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201H → Q in CAA68102. 1 Publication
Sequence conflicti212 – 2121T → N in CAA68102. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99769 mRNA. Translation: CAA68102.1.
BX649562, BX571825 Genomic DNA. Translation: CAP09513.1.
BX571825, BX649562 Genomic DNA. Translation: CAP09561.1.
RefSeqiNP_571062.1. NM_130987.1.
UniGeneiDr.75756.

Genome annotation databases

GeneIDi30180.
KEGGidre:30180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99769 mRNA. Translation: CAA68102.1 .
BX649562 , BX571825 Genomic DNA. Translation: CAP09513.1 .
BX571825 , BX649562 Genomic DNA. Translation: CAP09561.1 .
RefSeqi NP_571062.1. NM_130987.1.
UniGenei Dr.75756.

3D structure databases

ProteinModelPortali A8E7N9.
SMRi A8E7N9. Positions 308-412.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 30180.
KEGGi dre:30180.

Organism-specific databases

CTDi 30180.
ZFINi ZDB-GENE-980526-442. gdf6b.

Phylogenomic databases

eggNOGi NOG249531.
HOGENOMi HOG000231514.
HOVERGENi HBG107938.
InParanoidi O12938.
OMAi ILVVFTR.
PhylomeDBi A8E7N9.
TreeFami TF316134.

Miscellaneous databases

NextBioi 20806648.

Gene expression databases

Bgeei A8E7N9.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00669. INHIBINA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Dynamo, a new zebrafish DVR member of the TGF-beta superfamily is expressed in the posterior neural tube and is up-regulated by Sonic hedgehog."
    Bruneau S., Rosa F.M.
    Mech. Dev. 61:199-212(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Tissue: Embryo.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.

Entry informationi

Entry nameiGDF6B_DANRE
AccessioniPrimary (citable) accession number: A8E7N9
Secondary accession number(s): O12938
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: November 13, 2007
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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