A8E7C2 (A8E7C2_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Novel protein similar to human and mouse Rho GTPase activating protein 21 (ARHGAP21) EMBL CAP09397.1

Gene names

Name:	arhgap21b ZFIN ZDB-GENE-030131-4944
Synonyms:	si:ch211-175p12.1 ZFIN ZDB-GENE-030131-4944
ORF Names:	CH211-175P12.1-001 EMBL CAP09397.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL CAP09397.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	1702 AA.
Sequence status	Fragment.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities

Contains 1 PDZ (DHR) domain. RuleBase RU003354 Contains 1 PH domain. RuleBase RU003350 SAAS SAAS000198 Contains 1 Rho-GAP domain. SAAS SAAS000198

Ontologies

Keywords
Molecular function	GTPase activation SAAS SAAS000198
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL CAP09397.1

Sequences

	Sequence		Length	Mass (Da)
	A8E7C2 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: F3B5358E4DBBFD7D	FASTA	1,702	187,793
	10 20 30 40 50 60 RPRNRLEPMD TIFVKQVKEG GPAHSAGLCT GDRIVKVNGE SIIGKTYSQV IGLIQNSHTF 70 80 90 100 110 120 LELCVMPKDE DILQLAYSQD AYLKGHDAYS GNARHIPEPP PICYPRVDCK PPGMAQATET 130 140 150 160 170 180 SAPGVVSSDL GYRVEIPVPP SPPPPIPKTQ TAVCVCNESV RTVVVPPDVH MGLMVQGHRG 190 200 210 220 230 240 DYGLVGPDPM LIRARPGTVS GGRPPYLHPR KADMFPSGYH GDPYAIPPTH YVPASSITSP 250 260 270 280 290 300 ATHQNIDWRT YQTYREYIDN KGIHAYSRTV QERLDSLRAA SQSTHGGPHC GPQPGWGNKL 310 320 330 340 350 360 RRRSTSHDRA YQGPSMLPPR SASQDRMSGA ERAAHARDWP PRSVSSDGLI RKPRAHSSDY 370 380 390 400 410 420 VEHGELVSAA PWAAPVDRQL YSRVDQRSRP SRQSLPPRAV LYRPPTGYGM SVRGNAGSHK 430 440 450 460 470 480 HSSRTDIPPT AGFPERPRNG INQAKEPPSK DQSGTVVGNR ILNSASNQSR TRAETMQSPE 490 500 510 520 530 540 SGKDISVGYR SASYSAPPLQ RPKGGASTQR TSSRDVKGLP VNGSSPVEGV VLREKPPTGK 550 560 570 580 590 600 GTPQPLRHPS YILAVNDTDG SEPAGGGVCW LPNDARREMR MQRLGERLDS SFCSSNLDES 610 620 630 640 650 660 LDSIPFIDEP ASPSVDHDGS HIPASVVISG AQAALSDSPS PSTPSPLMRR QLSHDQESLR 670 680 690 700 710 720 NAILESGTKT ERSKSYDEGL DNYREEGRGR SSKPSLRVFR KALDGHKSDD SSSRRDSSTE 730 740 750 760 770 780 IFSDSTKEGW LHFRQLNTEK GKRVGGGMRP WKQMYAVLRG HSLYLYKDKK EGLAHVNSQL 790 800 810 820 830 840 EDDPQSISIK ACLIDISYSD TKRKNVLRLT TSDCEYLFQA EGREDMLSWI RVIQENSNLD 850 860 870 880 890 900 EENAAVTSTD LINRKLKEYI SMSAPSSKTE PSPKTSRQSL SIRQTLLGGS SKSQSPYSPK 910 920 930 940 950 960 NEQDRSKDDS SPPRDKAAWR RGIPGLKKKP QDKRPAAGVT FGVRLDNCPP AQTNKFVPLI 970 980 990 1000 1010 1020 VEVCCKLVED RGLEYTGIYR VPGNNAAISS MQEELDTKGM TDIDIQDDKW RDLNVISSLL 1030 1040 1050 1060 1070 1080 KSFFRKLPEP LFTNEKYSNF IDANRMEDPV ERLKALKRLI HELPDHHYET LKFLSGHLKT 1090 1100 1110 1120 1130 1140 VSENCEKNKM EPRNLAIVFG PTLVRTSEDN MTHMVTHMPD QYKIVETLIQ QYDWFFTEDG 1150 1160 1170 1180 1190 1200 DEEPTTTVEQ ESTVQSQPVP NIDHLLTNIG RTAPSPGDVS DSTTSDSAKS KQGSWGTGKD 1210 1220 1230 1240 1250 1260 QYSSELLRTS IFASRKRKKP KDKPQPSSSD DDLDASFSKK DLPVQNDPNW PADDQTEDAE 1270 1280 1290 1300 1310 1320 SEVGLDDQRT EDDDQSPGDG LDLTSENKQL ITEHLPQQTC PSSKINTSPK PSYHMTRQSS 1330 1340 1350 1360 1370 1380 LSDHPSNYDD GCVSDLGTLN STSSQASVPR IRHGRTTGHW MESAGMGLGA EVCSITSDYS 1390 1400 1410 1420 1430 1440 TTSSMTFHTG VESIALSPEV QSVAESRGDD ADDERSELIS EGRPMETDSE SDLSVFAVGR 1450 1460 1470 1480 1490 1500 DGVPAEDSSQ LGGSVTPLQD VPSLIPSHRI IACDTLARKR GSRQKTDSES SADGSRSDKE 1510 1520 1530 1540 1550 1560 STRISRVLEA VKGRSTGSLS SSSRSESERA EPMWRIKITD RLKCRLRTSA DDMFGVGSQR 1570 1580 1590 1600 1610 1620 TRSPETRSKR KSNIRRRHTM GGQRDFAELS VIGDWQRVEG NELSAMDRLK PKCSSQDFSI 1630 1640 1650 1660 1670 1680 RDWIARERHR TSNPEVSLDV LDLHSSRSRD LLSAGPSHSY LGQHLNGDVA VAQGKSLSLG 1690 1700 ADAHPHKLSG AQVVRSRFYQ YL

References

[1]	Matthews N. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX005226 Genomic DNA. Translation: CAP09397.1.
IPI	IPI00494982.
UniGene	Dr.132678.
3D structure databases
ProteinModelPortal	A8E7C2.
ModBase	Search...
Protein-protein interaction databases
STRING	A8E7C2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ZFIN	ZDB-GENE-030131-4944. arhgap21b.
Phylogenomic databases
eggNOG	fiNOG09740.
GeneTree	ENSGT00600000084250.
HOGENOM	HBG505226.
HOVERGEN	HBG106694.
OMA	YSTTSSM.
OrthoDB	EOG4RR6GG.
Gene expression databases
Bgee	A8E7C2.
Family and domain databases
InterPro	IPR001478. PDZ/DHR/GLGF. IPR001605. PH_dom-spectrin-type. IPR011993. PH_type. IPR001849. Pleckstrin_homology. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:1.10.555.10. RhoGAP. 1 hit.
Pfam	PF00595. PDZ. 1 hit. PF00169. PH. 1 hit. PF00620. RhoGAP. 1 hit. [Graphical view]
PRINTS	PR00683. SPECTRINPH.
SMART	SM00228. PDZ. 1 hit. SM00233. PH. 1 hit. SM00324. RhoGAP. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit. SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50106. PDZ. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50238. RHOGAP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8E7C2_DANRE

Accession

Primary (citable) accession number: A8E7C2

Entry history

Integrated into UniProtKB/TrEMBL:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)