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A8E5V7 (NAA60_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-alpha-acetyltransferase 60

EC=2.3.1.48
EC=2.3.1.88
Alternative name(s):
N-acetyltransferase 15
NatF catalytic subunit
Gene names
Name:naa60
Synonyms:nat15
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase By similarity.

Catalytic activity

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subcellular location

Golgi apparatus membrane By similarity.

Sequence similarities

Belongs to the acetyltransferase family. NAA60 subfamily.

Contains 1 N-acetyltransferase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 242242N-alpha-acetyltransferase 60
PRO_0000321570

Regions

Domain13 – 182170N-acetyltransferase

Sequences

Sequence LengthMass (Da)Tools
A8E5V7 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: D9F47EBE43CC3FDB

FASTA24227,575
        10         20         30         40         50         60 
MSEEERPAAL ADTILRFLCH DDIDTVKELC ADWFPIEYPD SWYRDITSNK KFFSLAATYN 

        70         80         90        100        110        120 
GQIVGMIVAE IKGRTKVHKE DGDILASSFS GDTQVAYILS LGVVKEFRKQ GIGSLLLESL 

       130        140        150        160        170        180 
KSHISSTAQD HCKALYLHVL TTNSNAIRFY ENRHFHQHHY LPYYYSIRGV LQDAYTYVLY 

       190        200        210        220        230        240 
LNGGHPPWTV MDYLQHLGSA LAGFSPCTLP QRIYRQAHTL LRSLLPWSSI SAKSGIEYSR 


TM 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC153734 mRNA. Translation: AAI53735.1.
RefSeqNP_001106444.1. NM_001112973.1.
UniGeneStr.42853.

3D structure databases

ProteinModelPortalA8E5V7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000060272; ENSXETP00000063481; ENSXETG00000031356.
GeneID100127619.
KEGGxtr:100127619.

Organism-specific databases

CTD79903.
XenbaseXB-GENE-941561. naa60.

Phylogenomic databases

GeneTreeENSGT00390000008314.
HOVERGENHBG061680.
OMATVKQLCG.
OrthoDBEOG7M0NT7.
TreeFamTF323980.

Gene expression databases

BgeeA8E5V7.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAA60_XENTR
AccessionPrimary (citable) accession number: A8E5V7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 13, 2007
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families