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A8E5V7

- NAA60_XENTR

UniProt

A8E5V7 - NAA60_XENTR

Protein

N-alpha-acetyltransferase 60

Gene

naa60

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. H4 histone acetyltransferase activity Source: UniProtKB
    2. peptide alpha-N-acetyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. chromosome segregation Source: UniProtKB
    3. histone H4 acetylation Source: UniProtKB
    4. N-terminal peptidyl-methionine acetylation Source: UniProtKB
    5. nucleosome assembly Source: UniProtKB

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Chromosome partition

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-alpha-acetyltransferase 60 (EC:2.3.1.48, EC:2.3.1.88)
    Alternative name(s):
    N-acetyltransferase 15
    NatF catalytic subunit
    Gene namesi
    Name:naa60
    Synonyms:nat15
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-941561. naa60.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 242242N-alpha-acetyltransferase 60PRO_0000321570Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiA8E5V7.

    Structurei

    3D structure databases

    ProteinModelPortaliA8E5V7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 182170N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000008314.
    HOVERGENiHBG061680.
    OMAiTVKQLCG.
    OrthoDBiEOG7M0NT7.
    TreeFamiTF323980.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A8E5V7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEEERPAAL ADTILRFLCH DDIDTVKELC ADWFPIEYPD SWYRDITSNK    50
    KFFSLAATYN GQIVGMIVAE IKGRTKVHKE DGDILASSFS GDTQVAYILS 100
    LGVVKEFRKQ GIGSLLLESL KSHISSTAQD HCKALYLHVL TTNSNAIRFY 150
    ENRHFHQHHY LPYYYSIRGV LQDAYTYVLY LNGGHPPWTV MDYLQHLGSA 200
    LAGFSPCTLP QRIYRQAHTL LRSLLPWSSI SAKSGIEYSR TM 242
    Length:242
    Mass (Da):27,575
    Last modified:November 13, 2007 - v1
    Checksum:iD9F47EBE43CC3FDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC153734 mRNA. Translation: AAI53735.1.
    RefSeqiNP_001106444.1. NM_001112973.1.
    UniGeneiStr.42853.

    Genome annotation databases

    EnsembliENSXETT00000060272; ENSXETP00000063481; ENSXETG00000031356.
    GeneIDi100127619.
    KEGGixtr:100127619.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC153734 mRNA. Translation: AAI53735.1 .
    RefSeqi NP_001106444.1. NM_001112973.1.
    UniGenei Str.42853.

    3D structure databases

    ProteinModelPortali A8E5V7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000060272 ; ENSXETP00000063481 ; ENSXETG00000031356 .
    GeneIDi 100127619.
    KEGGi xtr:100127619.

    Organism-specific databases

    CTDi 79903.
    Xenbasei XB-GENE-941561. naa60.

    Phylogenomic databases

    GeneTreei ENSGT00390000008314.
    HOVERGENi HBG061680.
    OMAi TVKQLCG.
    OrthoDBi EOG7M0NT7.
    TreeFami TF323980.

    Gene expression databases

    Bgeei A8E5V7.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiNAA60_XENTR
    AccessioniPrimary (citable) accession number: A8E5V7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3