A8E5V7 (NAA60_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-alpha-acetyltransferase 60
EC=2.3.1.48
EC=2.3.1.88

Alternative name(s):
N-acetyltransferase 15
NatF catalytic subunit

Gene names

Name:	naa60
Synonyms:	nat15

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase By similarity.
Catalytic activity	Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA. Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Golgi apparatus membrane By similarity.
Sequence similarities	Belongs to the acetyltransferase family. NAA60 subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Chromosome partition
Cellular component	Golgi apparatus Membrane
Molecular function	Acyltransferase Chromatin regulator Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	N-terminal peptidyl-methionine acetylation Inferred from sequence or structural similarity. Source: UniProtKB cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB chromosome segregation Inferred from sequence or structural similarity. Source: UniProtKB nucleosome assembly Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	Golgi membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	H4 histone acetyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB peptide alpha-N-acetyltransferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	N-alpha-acetyltransferase 60		PRO_0000321570
Regions
	Domain	13 – 182	170	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	A8E5V7 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: D9F47EBE43CC3FDB	FASTA	242	27,575
	10 20 30 40 50 60 MSEEERPAAL ADTILRFLCH DDIDTVKELC ADWFPIEYPD SWYRDITSNK KFFSLAATYN 70 80 90 100 110 120 GQIVGMIVAE IKGRTKVHKE DGDILASSFS GDTQVAYILS LGVVKEFRKQ GIGSLLLESL 130 140 150 160 170 180 KSHISSTAQD HCKALYLHVL TTNSNAIRFY ENRHFHQHHY LPYYYSIRGV LQDAYTYVLY 190 200 210 220 230 240 LNGGHPPWTV MDYLQHLGSA LAGFSPCTLP QRIYRQAHTL LRSLLPWSSI SAKSGIEYSR TM

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC153734 mRNA. Translation: AAI53735.1.
RefSeq	NP_001106444.1. NM_001112973.1.
UniGene	Str.42853.
3D structure databases
ProteinModelPortal	A8E5V7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSXETT00000060272; ENSXETP00000063481; ENSXETG00000031356.
GeneID	100127619.
KEGG	xtr:100127619.
Organism-specific databases
CTD	79903.
Xenbase	XB-GENE-941561. naa60.
Phylogenomic databases
GeneTree	ENSGT00390000008314.
HOVERGEN	HBG061680.
OMA	PWTILYP.
Gene expression databases
Bgee	A8E5V7.
Family and domain databases
Gene3D	3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000182. GNAT_dom. [Graphical view]
Pfam	PF00583. Acetyltransf_1. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAA60_XENTR

Accession

Primary (citable) accession number: A8E5V7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 13, 2007
Last modified:	March 6, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program