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A8E5V7

- NAA60_XENTR

UniProt

A8E5V7 - NAA60_XENTR

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Protein

N-alpha-acetyltransferase 60

Gene

naa60

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. H4 histone acetyltransferase activity Source: UniProtKB
  2. peptide alpha-N-acetyltransferase activity Source: UniProtKB

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. chromosome segregation Source: UniProtKB
  3. histone H4 acetylation Source: UniProtKB
  4. N-terminal peptidyl-methionine acetylation Source: UniProtKB
  5. nucleosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Chromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 60 (EC:2.3.1.48, EC:2.3.1.88)
Alternative name(s):
N-acetyltransferase 15
NatF catalytic subunit
Gene namesi
Name:naa60
Synonyms:nat15
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-941561. naa60.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242N-alpha-acetyltransferase 60PRO_0000321570Add
BLAST

Expressioni

Gene expression databases

BgeeiA8E5V7.

Structurei

3D structure databases

ProteinModelPortaliA8E5V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 182170N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000008314.
HOVERGENiHBG061680.
InParanoidiA8E5V7.
OMAiTVKQLCG.
OrthoDBiEOG7M0NT7.
TreeFamiTF323980.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8E5V7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEEERPAAL ADTILRFLCH DDIDTVKELC ADWFPIEYPD SWYRDITSNK
60 70 80 90 100
KFFSLAATYN GQIVGMIVAE IKGRTKVHKE DGDILASSFS GDTQVAYILS
110 120 130 140 150
LGVVKEFRKQ GIGSLLLESL KSHISSTAQD HCKALYLHVL TTNSNAIRFY
160 170 180 190 200
ENRHFHQHHY LPYYYSIRGV LQDAYTYVLY LNGGHPPWTV MDYLQHLGSA
210 220 230 240
LAGFSPCTLP QRIYRQAHTL LRSLLPWSSI SAKSGIEYSR TM
Length:242
Mass (Da):27,575
Last modified:November 13, 2007 - v1
Checksum:iD9F47EBE43CC3FDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC153734 mRNA. Translation: AAI53735.1.
RefSeqiNP_001106444.1. NM_001112973.1.
UniGeneiStr.42853.

Genome annotation databases

EnsembliENSXETT00000060272; ENSXETP00000063481; ENSXETG00000031356.
GeneIDi100127619.
KEGGixtr:100127619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC153734 mRNA. Translation: AAI53735.1 .
RefSeqi NP_001106444.1. NM_001112973.1.
UniGenei Str.42853.

3D structure databases

ProteinModelPortali A8E5V7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000060272 ; ENSXETP00000063481 ; ENSXETG00000031356 .
GeneIDi 100127619.
KEGGi xtr:100127619.

Organism-specific databases

CTDi 79903.
Xenbasei XB-GENE-941561. naa60.

Phylogenomic databases

GeneTreei ENSGT00390000008314.
HOVERGENi HBG061680.
InParanoidi A8E5V7.
OMAi TVKQLCG.
OrthoDBi EOG7M0NT7.
TreeFami TF323980.

Gene expression databases

Bgeei A8E5V7.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiNAA60_XENTR
AccessioniPrimary (citable) accession number: A8E5V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3