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Protein

Ribonucleoside-diphosphate reductase large subunit-like protein

Gene

M45

Organism
Murid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Does not possess a ribonucleotide reductase activity. Betaherpesviruses probably use another strategy to expand the dNTP pool in a quiescent host cell.UniRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase large subunit-like proteinUniRule annotation
Gene namesi
Name:M45Imported
Synonyms:RIR1UniRule annotation
OrganismiMurid herpesvirus 1 (strain K181) (MuHV-1) (Mouse cytomegalovirus)Imported
Taxonomic identifieri69156 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeMuromegalovirus
Virus hostiMus musculus (Mouse) [TaxID: 10090]
Proteomesi
  • UP000158680 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmUniRule annotation, VirionUniRule annotation

Expressioni

Keywords - Developmental stagei

Late proteinUniRule annotation

Interactioni

Protein-protein interaction databases

IntActiA8E1H1. 5 interactors.
MINTiMINT-7256055.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 71RHIMInterPro annotationAdd BLAST52
Domaini650 – 1133RIBORED_LARGEInterPro annotationAdd BLAST484

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

Family and domain databases

HAMAPiMF_04027. HSV_RIR1_betahv. 1 hit.
InterProiView protein in InterPro
IPR034716. HSV_RIR1_betahv.
IPR025735. RHIM_dom.
IPR000788. RNR_lg_C.
PfamiView protein in Pfam
PF12721. RHIM. 1 hit.
PF02867. Ribonuc_red_lgC. 1 hit.
PRINTSiPR01183. RIBORDTASEM1.

Sequencei

Sequence statusi: Complete.

A8E1H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRQPKVYSD PDNGFFFLDV PMPDDGQGGQ QTATTAAGGA FGVGGGHSVP
60 70 80 90 100
YVRIMNGVSG IQIGNHNAMS IASCWSPSYT DRRRRSYPKT ATNAAADRVA
110 120 130 140 150
AAVSAANAAV NAAAAAAAAG GGGGANLLAA AVTCANQRGC CGGNGGHSLP
160 170 180 190 200
PTRAPKTNAT AAAAPAVAVA SNAKSDNNHA NAASGAGSAA ATPAATTSAA
210 220 230 240 250
AAVENRRPSP SPSTASTAPC DEGSSPRHHR PSHVSVGTQA TPSTPIPIPA
260 270 280 290 300
PRCSTGQQQQ QPQAKKLKPA KADPLLYAAT MPPPASVTTA AAAAVAPESE
310 320 330 340 350
SSPAASAPPA AAAMATGGDD EDQSSFSFVS DDVLGEFEDL RIAGLPVRDE
360 370 380 390 400
MRPPTPTMTV IPVSRPFRAG RDSGRDALFD DAVESVRCYC HGILGNSRFC
410 420 430 440 450
ALVNEKCSEP AKERMARIRR YAADVTRCGP LALYTAIVSS ANRLIQTDPS
460 470 480 490 500
CDLDLAECYV ETASKRNAVP LSAFYRDCDR LRDAVAAFFK TYGMVVDAMA
510 520 530 540 550
QRITERVGPA LGRGLYSTVV MMDRCGNSFQ GREETPISVF ARVAAALAVE
560 570 580 590 600
CEVDGGVSYK ILSSKPVDAA QAFDAFLSAL CSFAIIPSPR VLAYAGFGGS
610 620 630 640 650
NPIFDAVSYR AQFYSAESTI NGTLHDICDM VTNGLSVSVS AADLGGDIVA
660 670 680 690 700
SLHILGQQCK ALRPYARFKT VLRIYFDIWS VDALKIFSFI LDVGREYEGL
710 720 730 740 750
MAFAVNTPRI FWDRYLDSSG DKMWLMFARR EAAALCGLDL KSFRNVYEKM
760 770 780 790 800
ERDGRSAITV SPWWAVCQLD ACVARGNTAV VFPHNVKSMI PENIGRPAVC
810 820 830 840 850
GPGVSVVSGG FVGCTPIHEL CINLENCVLE GAAVESSVDV VLGLGCRFSF
860 870 880 890 900
KALESLVRDA VVLGNLLIDM TVRTNAYGAG KLLTLYRDLH IGVVGFHAVM
910 920 930 940 950
NRLGQKFADM ESYDLNQRIA EFIYYTAVRA SVDLCMAGAD PFPKFPKSLY
960 970 980 990 1000
AAGRFYPDLF DDDERGPRRM TKEFLEKLRE DVVKHGIRNA SFITGCSADE
1010 1020 1030 1040 1050
AANLAGTTPG FWPRRDNVFL EQTPLMMTPT KDQMLDECVR SVKIEPHRLH
1060 1070 1080 1090 1100
EEDLSCLGEN RPVELPVLNS RLRQISKESA TVAVRRGRSA PFYDDSDDED
1110 1120 1130 1140 1150
EVACSETGWT VSTDAVIKMC VDRQPFVDHA QSLPVAIGFG GSSVELARHL
1160 1170
RRGNALGLSV GVYKCSMPPS VNYR
Length:1,174
Mass (Da):125,127
Last modified:November 13, 2007 - v1
Checksum:i449486931C4152D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM886412 Genomic DNA. Translation: CAP08092.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM886412 Genomic DNA. Translation: CAP08092.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA8E1H1. 5 interactors.
MINTiMINT-7256055.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_04027. HSV_RIR1_betahv. 1 hit.
InterProiView protein in InterPro
IPR034716. HSV_RIR1_betahv.
IPR025735. RHIM_dom.
IPR000788. RNR_lg_C.
PfamiView protein in Pfam
PF12721. RHIM. 1 hit.
PF02867. Ribonuc_red_lgC. 1 hit.
PRINTSiPR01183. RIBORDTASEM1.
ProtoNetiSearch...

Entry informationi

Entry nameiA8E1H1_MUHVK
AccessioniPrimary (citable) accession number: A8E1H1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: May 10, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks the conserved sequence Asn-x-Cys-x-Glu essential for ribonucleotide reductase activity.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.