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Protein

Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog

Gene

CG34183

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69ZincPROSITE-ProRule annotation1
Metal bindingi74ZincPROSITE-ProRule annotation1
Metal bindingi105ZincPROSITE-ProRule annotation1
Metal bindingi109ZincPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri46 – 129RTR1-typePROSITE-ProRule annotationAdd BLAST84

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog (EC:3.1.3.16)
Alternative name(s):
RNA polymerase II-associated protein 2
Gene namesi
ORF Names:CG34183
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0085212 CG34183

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004162901 – 143Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 homologAdd BLAST143

Proteomic databases

PaxDbiA8DYY5

Expressioni

Gene expression databases

BgeeiFBgn0085212

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0111291

Structurei

3D structure databases

ProteinModelPortaliA8DYY5
SMRiA8DYY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RPAP2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri46 – 129RTR1-typePROSITE-ProRule annotationAdd BLAST84

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4780 Eukaryota
ENOG410ZZZC LUCA
GeneTreeiENSGT00390000017965
InParanoidiA8DYY5
KOiK20827
OMAiKSQVPTS
OrthoDBiEOG091G0TLM
PhylomeDBiA8DYY5

Family and domain databases

Gene3Di1.25.40.8201 hit
InterProiView protein in InterPro
IPR007308 Rtr1/RPAP2
IPR038534 Rtr1/RPAP2_sf
PfamiView protein in Pfam
PF04181 RPAP2_Rtr1, 1 hit
PROSITEiView protein in PROSITE
PS51479 ZF_RTR1, 1 hit

Sequencei

Sequence statusi: Complete.

A8DYY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTEKGEQLR QQLIAAVVKK RAAIARAHEI VVRLLEPGIP EPEFLSLLCE
60 70 80 90 100
IGPPNYSDIV DEREINKLCG YPLCSTVLEN VPKQKYSISA SKNKVYDITE
110 120 130 140
RKKFCSGYCF KASEYIKSQV PTSPLWLRDR ETRPSFQLLP RNT
Length:143
Mass (Da):16,330
Last modified:November 13, 2007 - v1
Checksum:iB96163550CC3AC7E
GO

Sequence cautioni

The sequence ABL75686 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24Missing in ABL75663 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: ABV53661.1
BT029562 mRNA Translation: ABL75622.1
BT029604 mRNA Translation: ABL75663.1
BT029627 mRNA Translation: ABL75686.1 Different initiation.
RefSeqiNP_001097134.1, NM_001103664.2
UniGeneiDm.25279

Genome annotation databases

EnsemblMetazoaiFBtr0112376; FBpp0111291; FBgn0085212
GeneIDi5740752
KEGGidme:Dmel_CG34183
UCSCiCG34183-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiRPAP2_DROME
AccessioniPrimary (citable) accession number: A8DYY5
Secondary accession number(s): A1A6P2, A1A6T3, A1A6V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: November 13, 2007
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome