A8DYP9 (LPFUR_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fur leader peptide

Gene names

Name:	uof
Ordered Locus Names:	b4637

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	28 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cotranscribed with fur, it is essential for fur translation. The fur ribosomal binding site (RBS) is occluded by the 5'-mRNA secondary structure, which is opened by uof translation. Ref.2
Induction	By iron depletion. Repressed by the ncRNA ryhB. Ref.2

Ontologies

Keywords
Molecular function	Leader peptide
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of translation Inferred from direct assay Ref.2. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 28	28	Fur leader peptide		PRO_0000315217

Sequences

	Sequence		Length	Mass (Da)
	A8DYP9 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 3A799921ABC715B4	FASTA	28	3,109
	10 20 MIRIISRANS VTSSNEVNRL VTGQIPHD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Control of Fur synthesis by the non-coding RNA RyhB and iron-responsive decoding." Vecerek B., Moll I., Blaesi U. EMBO J. 26:965-975(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN TRANSLATION OF FUR, INDUCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U00096 Genomic DNA. Translation: ABV59574.1.
RefSeq	YP_001491546.1. NC_000913.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	511145.b4637.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABV59574; ABV59574; b4637.
GeneID	5625562.
KEGG	eco:b4637.
Organism-specific databases
EcoGene	EG14465. uof.
Phylogenomic databases
ProtClustDB	PRK14761.
Enzyme and pathway databases
BioCyc	EcoCyc:MONOMER0-2801.
Gene expression databases
Genevestigator	A8DYP9.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

LPFUR_ECOLI

Accession

Primary (citable) accession number: A8DYP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 13, 2007
Last modified:	May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program