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A8DQK9

- NU4M_AVACL

UniProt

A8DQK9 - NU4M_AVACL

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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Avahi cleesei (Cleese's woolly lemur)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiAvahi cleesei (Cleese's woolly lemur)
Taxonomic identifieri402244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLemuriformesIndriidaeAvahi

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459NADH-ubiquinone oxidoreductase chain 4PRO_0000323384Add
BLAST

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei95 – 11117HelicalSequence AnalysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei194 – 21421HelicalSequence AnalysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30320HelicalSequence AnalysisAdd
BLAST
Transmembranei308 – 33023HelicalSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

A8DQK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKIIIPTIM LFPVTWYSKN SMIWINTTSH SLMISLMGLL LLNHPSNNSN
60 70 80 90 100
NFSLNFFSDP LSSPLLMLTM WLLPLMIMAS QHHLAKEPWF RKKSYLSMLI
110 120 130 140 150
TLQMFLIMTF MATELILFYI LFEATLIPTL IIITRWGNQT ERLNAGMYFL
160 170 180 190 200
FYTLTGSLPL LVALIYLQSS MGSLNLLTIN LWLKELPNSW STNLLWMACI
210 220 230 240 250
MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG YGMMRITIIL
260 270 280 290 300
DPTTKSMAYP FLMLCLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA
310 320 330 340 350
ILVQTPLGFM GATALMIAHG LTSSMLFCLA NSNYERIHSR TMLMARGLQT
360 370 380 390 400
LLPLMTTWWL LASLNNLALP PSINLIGELL VTITSFSWSN ITVILIGLNM
410 420 430 440 450
LITALYSLYM LITTQRGKLT YYLHNLNPSL TRENTLMSMH MLPLLFLTLN

PKIILGPTF
Length:459
Mass (Da):51,929
Last modified:November 13, 2007 - v1
Checksum:iAE1F0008CCAEDE79
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191K → N in strain: Isolate BEMA8.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ856113 Genomic DNA. Translation: ABI54997.1.
DQ856114 Genomic DNA. Translation: ABI55001.1.
DQ856115 Genomic DNA. Translation: ABI55005.1.
DQ856116 Genomic DNA. Translation: ABI55009.1.
DQ856117 Genomic DNA. Translation: ABI55013.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ856113 Genomic DNA. Translation: ABI54997.1 .
DQ856114 Genomic DNA. Translation: ABI55001.1 .
DQ856115 Genomic DNA. Translation: ABI55005.1 .
DQ856116 Genomic DNA. Translation: ABI55009.1 .
DQ856117 Genomic DNA. Translation: ABI55013.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG093667.

Family and domain databases

InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view ]
PRINTSi PR01437. NUOXDRDTASE4.
TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular phylogeny and taxonomic revision of the woolly lemurs, genus Avahi (primates: lemuriformes)."
    Andriantompohavana R., Lei R., Zaonarivelo J.R., Engberg S.E., Nalanirina G., McGuire S.M., Shore G.D., Andrianasolo J., Herrington K., Brenneman R.A., Louis E.E. Jr.
    Spec. Publ. Mus. Tex. Tech. Univ. 51:1-64(2007)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Isolate BEMA12, Isolate BEMA13, Isolate BEMA14, Isolate BEMA8 and Isolate BEMA9.

Entry informationi

Entry nameiNU4M_AVACL
AccessioniPrimary (citable) accession number: A8DQK9
Secondary accession number(s): A8DQK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3