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A8DQK9 (NU4M_AVACL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4
Gene names
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded onMitochondrion
OrganismAvahi cleesei (Cleese's woolly lemur)
Taxonomic identifier402244 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLemuriformesIndriidaeAvahi

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459NADH-ubiquinone oxidoreductase chain 4
PRO_0000323384

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane95 – 11117Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane194 – 21421Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane284 – 30320Helical; Potential
Transmembrane308 – 33023Helical; Potential
Transmembrane342 – 36221Helical; Potential
Transmembrane391 – 41121Helical; Potential

Natural variations

Natural variant191K → N in strain: Isolate BEMA8.

Sequences

Sequence LengthMass (Da)Tools
A8DQK9 [UniParc].

Last modified November 13, 2007. Version 1.
Checksum: AE1F0008CCAEDE79

FASTA45951,929
        10         20         30         40         50         60 
MLKIIIPTIM LFPVTWYSKN SMIWINTTSH SLMISLMGLL LLNHPSNNSN NFSLNFFSDP 

        70         80         90        100        110        120 
LSSPLLMLTM WLLPLMIMAS QHHLAKEPWF RKKSYLSMLI TLQMFLIMTF MATELILFYI 

       130        140        150        160        170        180 
LFEATLIPTL IIITRWGNQT ERLNAGMYFL FYTLTGSLPL LVALIYLQSS MGSLNLLTIN 

       190        200        210        220        230        240 
LWLKELPNSW STNLLWMACI MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG 

       250        260        270        280        290        300 
YGMMRITIIL DPTTKSMAYP FLMLCLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA 

       310        320        330        340        350        360 
ILVQTPLGFM GATALMIAHG LTSSMLFCLA NSNYERIHSR TMLMARGLQT LLPLMTTWWL 

       370        380        390        400        410        420 
LASLNNLALP PSINLIGELL VTITSFSWSN ITVILIGLNM LITALYSLYM LITTQRGKLT 

       430        440        450 
YYLHNLNPSL TRENTLMSMH MLPLLFLTLN PKIILGPTF 

« Hide

References

[1]"Molecular phylogeny and taxonomic revision of the woolly lemurs, genus Avahi (primates: lemuriformes)."
Andriantompohavana R., Lei R., Zaonarivelo J.R., Engberg S.E., Nalanirina G., McGuire S.M., Shore G.D., Andrianasolo J., Herrington K., Brenneman R.A., Louis E.E. Jr.
Spec. Publ. Mus. Tex. Tech. Univ. 51:1-64(2007)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Isolate BEMA12, Isolate BEMA13, Isolate BEMA14, Isolate BEMA8 and Isolate BEMA9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ856113 Genomic DNA. Translation: ABI54997.1.
DQ856114 Genomic DNA. Translation: ABI55001.1.
DQ856115 Genomic DNA. Translation: ABI55005.1.
DQ856116 Genomic DNA. Translation: ABI55009.1.
DQ856117 Genomic DNA. Translation: ABI55013.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG093667.

Family and domain databases

InterProIPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4M_AVACL
AccessionPrimary (citable) accession number: A8DQK9
Secondary accession number(s): A8DQK5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 13, 2007
Last modified: February 19, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families