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Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Avahi unicolor (Sambirano woolly lemur)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4
Gene namesi
Name:MT-ND4
Synonyms:MTND4, NADH4, ND4
Encoded oniMitochondrion
OrganismiAvahi unicolor (Sambirano woolly lemur)
Taxonomic identifieri402239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLemuriformesIndriidaeAvahi

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei94 – 112HelicalSequence analysisAdd BLAST19
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei284 – 303HelicalSequence analysisAdd BLAST20
Transmembranei308 – 330HelicalSequence analysisAdd BLAST23
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003233851 – 459NADH-ubiquinone oxidoreductase chain 4Add BLAST459

Structurei

3D structure databases

ProteinModelPortaliA8DQI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

A8DQI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKIIIPTIM LFPVTWYSNN SMIWINTTSH SLMISLMGLF LLNHPSNNSN
60 70 80 90 100
NFSLNFFSDP LSSPLLMLTM WLLPLMIMAS QYHLAKEPWF RKKSYLSMLI
110 120 130 140 150
TLQTFLIMTF MATELILFYI LFEATLIPTL IIITRWGNQT ERLNAGMYFL
160 170 180 190 200
FYTLTGSLPL LVALIYLQNS MGSLNLLTIN LWLKELPNSW STNLLWMACI
210 220 230 240 250
MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG YGMMRITMIL
260 270 280 290 300
DPTTKSMAYP FLMLCLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA
310 320 330 340 350
ILVQTPLGFM GATALMIAHG LTSSMLFCLA NSNYERIHSR TMLMARGLQT
360 370 380 390 400
LLPLTATWWL LASLNNLALP PSINLIGELL VTITSFSWSN ITVILIGLNM
410 420 430 440 450
LITALYSLYM LITTQRGKLT YYLHNLNPSL TRENTLMSMH ILPLLFLTLN

PKIILGPTF
Length:459
Mass (Da):51,912
Last modified:November 13, 2007 - v1
Checksum:i7E548F9FB9BF4677
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti54L → I in strain: isolate ANT5.10. 1
Natural varianti231L → H in strain: isolate ANT5.10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ856109 Genomic DNA. Translation: ABI54981.1.
DQ856110 Genomic DNA. Translation: ABI54985.1.
DQ856111 Genomic DNA. Translation: ABI54989.1.
DQ856112 Genomic DNA. Translation: ABI54993.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ856109 Genomic DNA. Translation: ABI54981.1.
DQ856110 Genomic DNA. Translation: ABI54985.1.
DQ856111 Genomic DNA. Translation: ABI54989.1.
DQ856112 Genomic DNA. Translation: ABI54993.1.

3D structure databases

ProteinModelPortaliA8DQI9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG093667.

Family and domain databases

InterProiIPR000260. NADH4_N.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR003918. NADH_UbQ_OxRdtase.
IPR001750. ND/Mrp_mem.
[Graphical view]
PfamiPF01059. Oxidored_q5_N. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU4M_AVAUN
AccessioniPrimary (citable) accession number: A8DQI9
Secondary accession number(s): A8DQJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.