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A8DQI9

- NU4M_AVAUN

UniProt

A8DQI9 - NU4M_AVAUN

Protein

NADH-ubiquinone oxidoreductase chain 4

Gene

MT-ND4

Organism
Avahi unicolor (Sambirano woolly lemur)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 4 (EC:1.6.5.3)
    Alternative name(s):
    NADH dehydrogenase subunit 4
    Gene namesi
    Name:MT-ND4
    Synonyms:MTND4, NADH4, ND4
    Encoded oniMitochondrion
    OrganismiAvahi unicolor (Sambirano woolly lemur)
    Taxonomic identifieri402239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLemuriformesIndriidaeAvahi

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 459459NADH-ubiquinone oxidoreductase chain 4PRO_0000323385Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei194 – 21421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei284 – 30320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei308 – 33023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei391 – 41121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 4 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG093667.

    Family and domain databases

    InterProiIPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view]
    PfamiPF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view]
    PRINTSiPR01437. NUOXDRDTASE4.
    TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A8DQI9-1 [UniParc]FASTAAdd to Basket

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    MLKIIIPTIM LFPVTWYSNN SMIWINTTSH SLMISLMGLF LLNHPSNNSN    50
    NFSLNFFSDP LSSPLLMLTM WLLPLMIMAS QYHLAKEPWF RKKSYLSMLI 100
    TLQTFLIMTF MATELILFYI LFEATLIPTL IIITRWGNQT ERLNAGMYFL 150
    FYTLTGSLPL LVALIYLQNS MGSLNLLTIN LWLKELPNSW STNLLWMACI 200
    MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG YGMMRITMIL 250
    DPTTKSMAYP FLMLCLWGMI MTSSICLRQT DLKSLIAYSS VSHMALVIVA 300
    ILVQTPLGFM GATALMIAHG LTSSMLFCLA NSNYERIHSR TMLMARGLQT 350
    LLPLTATWWL LASLNNLALP PSINLIGELL VTITSFSWSN ITVILIGLNM 400
    LITALYSLYM LITTQRGKLT YYLHNLNPSL TRENTLMSMH ILPLLFLTLN 450
    PKIILGPTF 459
    Length:459
    Mass (Da):51,912
    Last modified:November 13, 2007 - v1
    Checksum:i7E548F9FB9BF4677
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541L → I in strain: isolate ANT5.10.
    Natural varianti231 – 2311L → H in strain: isolate ANT5.10.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ856109 Genomic DNA. Translation: ABI54981.1.
    DQ856110 Genomic DNA. Translation: ABI54985.1.
    DQ856111 Genomic DNA. Translation: ABI54989.1.
    DQ856112 Genomic DNA. Translation: ABI54993.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ856109 Genomic DNA. Translation: ABI54981.1 .
    DQ856110 Genomic DNA. Translation: ABI54985.1 .
    DQ856111 Genomic DNA. Translation: ABI54989.1 .
    DQ856112 Genomic DNA. Translation: ABI54993.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG093667.

    Family and domain databases

    InterProi IPR010227. NADH_Q_OxRdtase_chainM/4.
    IPR001750. NADH_UbQ/plastoQ_OxRdtase.
    IPR003918. NADH_UbQ_OxRdtase.
    IPR000260. NADH_UbQ_OxRdtase_chain4_N.
    [Graphical view ]
    Pfami PF00361. Oxidored_q1. 1 hit.
    PF01059. Oxidored_q5_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01437. NUOXDRDTASE4.
    TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular phylogeny and taxonomic revision of the woolly lemurs, genus Avahi (primates: lemuriformes)."
      Andriantompohavana R., Lei R., Zaonarivelo J.R., Engberg S.E., Nalanirina G., McGuire S.M., Shore G.D., Andrianasolo J., Herrington K., Brenneman R.A., Louis E.E. Jr.
      Spec. Publ. Mus. Tex. Tech. Univ. 51:1-64(2007)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Isolate ANT5.10, Isolate ANT5.12, Isolate ANT5.8 and Isolate ANT5.9.

    Entry informationi

    Entry nameiNU4M_AVAUN
    AccessioniPrimary (citable) accession number: A8DQI9
    Secondary accession number(s): A8DQJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3