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Protein

Galectin

Gene

Lgals8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. carbohydrate binding Source: MGI

GO - Biological processi

  1. plasma cell differentiation Source: MGI
  2. T cell costimulation Source: MGI
Complete GO annotation...

Keywords - Ligandi

LectinUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
GalectinUniRule annotation
Gene namesi
Name:Lgals8Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1928481. Lgals8.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriA8DIL0.

Family & Domainsi

Sequence similaritiesi

Contains 2 galectin domains.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
KOiK06832.
OMAiAWGEEER.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A8DIL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLNNLQNI IYNPIIPYVG TITEQLKPGS LIVIRGHVPK DSERFQVDFQ
60 70 80 90 100
LGNSLKPRAD VAFHFNPRFK RSSCIVCNTL TQEKWGWEEI TYDMPFRKEK
110 120 130 140 150
SFEIVFMVLK NKFQVAVNGR HVLLYAHRIS PEQIDTVGIY GKVNIHSIGF
160 170 180 190 200
RFSSASALPH TLGDLQSMET SALGLTQINR ENIQKPGKLQ LSLPFEARLN
210 220 230 240 250
ASMGPGRTVV IKGEVNTNAR SFNVDLVAGK TRDIALHLNP RLNVKAFVRN
260 270 280 290 300
SFLQDAWGEE ERNITCFPFS SGMYFEMIIY CDVREFKVAI NGVHSLEYKH
310 320
RFKDLSSIDT LSVDGDIRLL DVRSW
Length:325
Mass (Da):37,010
Last modified:November 13, 2007 - v1
Checksum:i8784E4C445C8845F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154221 Genomic DNA. No translation available.
EF524570 mRNA. Translation: ABS45108.1.
RefSeqiNP_001277984.1. NM_001291055.1.
NP_001277989.1. NM_001291060.1.
XP_006516775.1. XM_006516712.1.
UniGeneiMm.474138.
Mm.486765.

Genome annotation databases

EnsembliENSMUST00000144283; ENSMUSP00000114200; ENSMUSG00000057554.
GeneIDi56048.
KEGGimmu:56048.
UCSCiuc011ywf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154221 Genomic DNA. No translation available.
EF524570 mRNA. Translation: ABS45108.1.
RefSeqiNP_001277984.1. NM_001291055.1.
NP_001277989.1. NM_001291060.1.
XP_006516775.1. XM_006516712.1.
UniGeneiMm.474138.
Mm.486765.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000144283; ENSMUSP00000114200; ENSMUSG00000057554.
GeneIDi56048.
KEGGimmu:56048.
UCSCiuc011ywf.1. mouse.

Organism-specific databases

CTDi3964.
MGIiMGI:1928481. Lgals8.

Phylogenomic databases

GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
KOiK06832.
OMAiAWGEEER.

Miscellaneous databases

ChiTaRSiLgals8. mouse.
NextBioi35545146.
SOURCEiSearch...

Gene expression databases

GenevestigatoriA8DIL0.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Galectin-8 induces apoptosis in the CD4(high)CD8(high) thymocyte subpopulation."
    Tribulatti M.V., Mucci J., Cattaneo V., Aguero F., Gilmartin T., Head S.R., Campetella O.
    Glycobiology 17:1404-1412(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: ThymusImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiA8DIL0_MOUSE
AccessioniPrimary (citable) accession number: A8DIL0
Entry historyi
Integrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: March 4, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.