A8CTY3 (A8CTY3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Intersectin 1 long form variant 3 EMBL ABV24867.1

Submitted name:
Intersectin-1 Ensembl ENSP00000387377

Gene names

Name:

ITSN1 Ensembl ENSP00000387377 EMBL ABV24867.1

Organism

Homo sapiens (Human) [Reference proteome] EMBL ABV24867.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1660 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. RuleBase RU003412 Contains 1 DH (DBL-homology) domain. SAAS SAAS000219 Contains 1 PH domain. SAAS SAAS008973 RuleBase RU003350 Contains 5 SH3 domains. RuleBase RU003338

Ontologies

Keywords
Domain	SH3 domain SAAS SAAS000108 RuleBase RU003338
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endocytosis Inferred from electronic annotation. Source: InterPro regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro calcium ion binding Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A8CTY3 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 715F81F741A346E4	FASTA	1,660	188,382
	10 20 30 40 50 60 MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ 70 80 90 100 110 120 IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPP VMKQQPVAIS SAPAFGMGGI 130 140 150 160 170 180 ASMPPLTAVA PVPMGSIPVV GMSPTLVSSV PTAAVPPLAN GAPPVIQPLP AFAHPAATLP 190 200 210 220 230 240 KSSSFSRSGP GSQLNTKLQK AQSFDVASVP PVAEWAVPQS SRLKYRQLFN SHDKTMSGHL 250 260 270 280 290 300 TGPQARTILM QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP 310 320 330 340 350 360 PEYIPPSFRR VRSGSGISVI SSTSVDQRLP EEPVLEDEQQ QLEKKLPVTF EDKKRENFER 370 380 390 400 410 420 GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE QERKRQLELE KQLEKQRELE 430 440 450 460 470 480 RQREEERRKE IERREAAKRE LERQRQLEWE RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF 490 500 510 520 530 540 ELEALNDKKH QLEGKLQDIR CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQESQQMLGR 550 560 570 580 590 600 LIPEKQILND QLKQVQQNSL HRDSLVTLKR ALEAKELARQ HLRDQLDEVE KETRSKLQEI 610 620 630 640 650 660 DIFNNQLKEL REIHNKQQLQ KQKSMEAERL KQKEQERKII ELEKQKEEAQ RRAQERDKQW 670 680 690 700 710 720 LEHVQQEDEH QRPRKLHEEE KLKREESVKK KDGEEKGKQE AQDKLGRLFH QHQEPAKPAV 730 740 750 760 770 780 QAPWSTAEKG PLTISAQENV KVVYYRALYP FESRSHDEIT IQPGDIVMVD ESQTGEPGWL 790 800 810 820 830 840 GGELKGKTGW FPANYAEKIP ENEVPAPVKP VTDSTSAPAP KLALRETPAP LAVTSSEPST 850 860 870 880 890 900 TPNNWADFSS TWPTSTNEKP ETDNWDAWAA QPSLTVPSAG QLRQRSAFTP ATATGSSPSP 910 920 930 940 950 960 VLGQGEKVEG LQAQALYPWR AKKDNHLNFN KNDVITVLEQ QDMWWFGEVQ GQKGWFPKSY 970 980 990 1000 1010 1020 VKLISGPIRK STSMDSGSSE SPASLKRVAS PAAKPVVSGE EFIAMYTYES SEQGDLTFQQ 1030 1040 1050 1060 1070 1080 GDVILVTKKD GDWWTGTVGD KAGVFPSNYV RLKDSEGSGT AGKTGSLGKK PEIAQVIASY 1090 1100 1110 1120 1130 1140 TATGPEQLTL APGQLILIRK KNPGGWWEGE LQARGKKRQI GWFPANYVKL LSPGTSKITP 1150 1160 1170 1180 1190 1200 TEPPKSTALA AVCQVIGMYD YTAQNDDELA FNKGQIINVL NKEDPDWWKG EVNGQVGLFP 1210 1220 1230 1240 1250 1260 SNYVKLTTDM DPSQQWCSDL HLLDMLTPTE RKRQGYIHEL IVTEENYVND LQLVTEIFQK 1270 1280 1290 1300 1310 1320 PLMESELLTE KEVAMIFVNW KELIMCNIKL LKALRVRKKM SGEKMPVKMI GDILSAQLPH 1330 1340 1350 1360 1370 1380 MQPYIRFCSR QLNGAALIQQ KTDEAPDFKE FVKRLAMDPR CKGMPLSSFI LKPMQRVTRY 1390 1400 1410 1420 1430 1440 PLIIKNQLVF NSVTNCLGPR KFLHSGKLYK AKSNKELYGF LFNDFLLLTQ ITKPLGSSGT 1450 1460 1470 1480 1490 1500 DKVFSPKSNL QYKMYKTPIF LNEVLVKLPT DPSGDEPIFH ISHIDRVYTL RAESINERTA 1510 1520 1530 1540 1550 1560 WVQKIKAASE LYIETEKKKR EKAYLVRSQR ATGIGRLMVN VVEGIELKPC RSHGKSNPYC 1570 1580 1590 1600 1610 1620 EVTMGSQCHI TKTIQDTLNP KWNSNCQFFI RDLEQEVLCI TVFERDQFSP DDFLGRTEIR 1630 1640 1650 1660 VADIKKDQGS KGPVTKCLLL HEVPTGEIVV RLDLQLFDEP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 21." Chromosome 21 mapping and sequencing consortium Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Structural diversity and differential expression of novel human intersectin 1 isoforms." Kropyvko S., Gerasymchuk D., Skrypkina I., Dergai M., Dergai O., Nikolaienko O., Rynditch A., Tsyba L. Mol. Biol. Rep. 37:2789-2796(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL ABV24867.1.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP000308 Genomic DNA. No translation available. AP000309 Genomic DNA. No translation available. AP000310 Genomic DNA. No translation available. AP000311 Genomic DNA. No translation available. AP000312 Genomic DNA. No translation available. AP000313 Genomic DNA. No translation available. EU120734 mRNA. Translation: ABV24867.1.
IPI	IPI00451616.
UniGene	Hs.160324.
3D structure databases
SMR	A8CTY3. Positions 1-111, 210-312, 908-966, 1000-1055, 1065-1517, 1534-1657.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000437442; ENSP00000387377; ENSG00000205726.
UCSC	uc002ytj.2. human.
Organism-specific databases
HGNC	HGNC:6183. ITSN1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG052159.
Family and domain databases
Gene3D	1.10.238.10. 2 hits. 1.20.900.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR000219. DH-domain. IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR000261. EPS15_homology. IPR026813. ITSN1. IPR000108. p67phox. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
PANTHER	PTHR11216:SF28. PTHR11216:SF28. 1 hit.
Pfam	PF00168. C2. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF00018. SH3_1. 3 hits. PF07653. SH3_2. 2 hits. [Graphical view]
PRINTS	PR00499. P67PHOX. PR00452. SH3DOMAIN.
SMART	SM00239. C2. 1 hit. SM00054. EFh. 2 hits. SM00027. EH. 2 hits. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00326. SH3. 5 hits. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF48065. DH-domain. 1 hit. SSF50044. SH3. 5 hits.
PROSITE	PS50004. C2. 1 hit. PS50010. DH_2. 1 hit. PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. PS50031. EH. 2 hits. PS50003. PH_DOMAIN. 1 hit. PS50002. SH3. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	35463617.

Entry information

Entry name

A8CTY3_HUMAN

Accession

Primary (citable) accession number: A8CTY3
Secondary accession number(s): E9PHV2

Entry history

Integrated into UniProtKB/TrEMBL:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	May 29, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.