Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

PBAN-type neuropeptides

Gene

PBAN

Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

A hormone that controls sex pheromone production in females and pheromone responsiveness in male. Also mediates visceral muscle contractile activity (myotropic activity) (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Neuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
PBAN-type neuropeptides
Alternative name(s):
Pheromone/pyrokinin biosynthesis-activating neuropeptide
Cleaved into the following 4 chains:
Alternative name(s):
Pyrokinin-1
Alternative name(s):
Pyrokinin-2
Gene namesi
Name:PBAN1 Publication
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 331 PublicationAdd BLAST33
PropeptideiPRO_000033926534 – 631 PublicationAdd BLAST30
PeptideiPRO_000033926666 – 80TSQDITSGMWFGPRL-amide1 PublicationAdd BLAST15
PropeptideiPRO_000033926786 – 1171 PublicationAdd BLAST32
PeptideiPRO_0000339268120 – 128QITQFTPRL-amide1 Publication9
PropeptideiPRO_0000339269131 – 1531 PublicationAdd BLAST23
PeptideiPRO_0000339270154 – 163IYLPLFASRL-amide1 Publication10
PeptideiPRO_0000339271167 – 175VPWTPSPRL-amide1 Publication9
PropeptideiPRO_0000339272178 – 1951 PublicationAdd BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80Leucine amide1 Publication1
Modified residuei120Pyrrolidone carboxylic acid1 Publication1
Modified residuei128Leucine amide1 Publication1
Modified residuei163Leucine amide1 Publication1
Modified residuei175Leucine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiA8CL69.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiA8CL69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi82 – 85Poly-ArgSequence analysis4

Sequence similaritiesi

Belongs to the pyrokinin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JHAK. Eukaryota.
ENOG410Z8VU. LUCA.
InParanoidiA8CL69.
OMAiITSGMWF.

Family and domain databases

InterProiView protein in InterPro
IPR001484. Pyrokinin_CS.
PROSITEiView protein in PROSITE
PS00539. PYROKININ. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A8CL69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGFAVFSSF NRFTTIFVCV LLCVVYLLSY ASGEYDGRDS SSGSNNDRAP
60 70 80 90 100
SNEFGSCTDG KCIKRTSQDI TSGMWFGPRL GRRRRADRKP EINSDIEAFA
110 120 130 140 150
NAFEEPHWAI VTIPETEKRQ ITQFTPRLGR ESGEDYFSYG FPKDQEELYT
160 170 180 190
EEQIYLPLFA SRLGRRVPWT PSPRLGRQLH NIVDKPRQNF NDPRF
Length:195
Mass (Da):22,455
Last modified:November 13, 2007 - v1
Checksum:i0FF4096BF7431BE2
GO

Mass spectrometryi

Molecular mass is 1693.82 Da from positions 66 - 80. Determined by MALDI. 1 Publication
Molecular mass is 1101.63 Da from positions 120 - 128. Determined by MALDI. 1 Publication
Molecular mass is 1084.60 Da from positions 120 - 128. Determined by MALDI. Lacking the pyrrolidone carboxylic acid modification.1 Publication
Molecular mass is 1190.72 Da from positions 154 - 163. Determined by MALDI. 1 Publication
Molecular mass is 1050.60 Da from positions 167 - 175. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ199622 mRNA. Translation: ABB05501.1.
RefSeqiNP_001104182.1. NM_001110712.2.
UniGeneiAme.10930.

Genome annotation databases

EnsemblMetazoaiGB46057-RA; GB46057-PA; GB46057.
GeneIDi100126690.
KEGGiame:100126690.

Similar proteinsi

Entry informationi

Entry nameiPBAN_APIME
AccessioniPrimary (citable) accession number: A8CL69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 13, 2007
Last modified: August 30, 2017
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families