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Protein

Taraxerol synthase

Gene

M2

Organism
Rhizophora stylosa (Bakau) (Red mangrove)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Multifunctional triterpene synthase producing taraxerol, beta-amyrin and lupeol in the ratio 70:17:13.

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = taraxerol.

GO - Molecular functioni

  1. intramolecular transferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14454.

Names & Taxonomyi

Protein namesi
Recommended name:
Taraxerol synthase (EC:5.4.99.35)
Short name:
RsM2
Gene namesi
Name:M2
OrganismiRhizophora stylosa (Bakau) (Red mangrove)
Taxonomic identifieri98588 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesRhizophoraceaeRhizophora

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 771771Taraxerol synthasePRO_0000412988Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati150 – 19142PFTB 1Add
BLAST
Repeati516 – 56146PFTB 2Add
BLAST
Repeati642 – 68342PFTB 3Add
BLAST

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated
Contains 3 PFTB repeats.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.

Sequencei

Sequence statusi: Complete.

A8C981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVWRLKIGE GANNPYLTST NNFVGRQTWV FEPDGGTPEE RDQVEEARQN
60 70 80 90 100
YFKNRFRVRP CSDLLWQMQF LREKNFRQKI PQVKVRDGEE INYETVTNAI
110 120 130 140 150
RRSAHYLSAT QSSDGFWPAD ASAPVFYLAP WVIGLYVIGH LNTVFPAEHQ
160 170 180 190 200
KEILRYIYCH QNEDGGWGLH YEDGGTMFGT AFNYVCMRIL GEGPGGGRDN
210 220 230 240 250
ACERARKGIL DHGGVTYIPS GGKTWLAMLG VFDWSGCNPM PPEFWMLPPF
260 270 280 290 300
FPMHPAQMWC YCRIVYMPMS YLYGRRFVGP ITPLVQQLRE ELHTQPFHEI
310 320 330 340 350
EWSKARHLCA KEDLFHRRPW IQELFWDCLH TFAEPLLTRW PLNNFIREKA
360 370 380 390 400
LKITMEHVHY DDKASHYINP GSVEKVICMV ACWVEDPSGE PFQRHLARIS
410 420 430 440 450
DYVWIAEDGM RITGIGSQTW DAALSIQALI ACNLIEEMGP TLKKGYDFLK
460 470 480 490 500
NSQAKDNPPG DFKRMYRHFG KGAWAFSSQD YGVIALDCTA ESLMCCLHFS
510 520 530 540 550
MMPPEIVGEK LEPEKLYLAV DFILSLQSKN GGLTCWEPAR GGKWLEVLNP
560 570 580 590 600
LEFFENIVVE HEYVEVTASA INALVMFKKR YPGYREKEIE HFISKAVHYL
610 620 630 640 650
IQTQFPNGPW YGVWGICFMY GTYFALKGLA AAGNTYANCP AIPKAVDFLL
660 670 680 690 700
KTQCQDGGWG ESYLSGTTKV YTPLEGNRSN LVQTAWALMG LIHSGQAERD
710 720 730 740 750
PTPLHRSAKL LINSQTSDGD FPQQDSTGLL KGSCAMHYAA YRNIFPLWAL
760 770
AAYRTHVLGL TSKAHSSAVM E
Length:771
Mass (Da):87,831
Last modified:November 13, 2007 - v1
Checksum:i8515AFA482981022
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB263204 mRNA. Translation: BAF80442.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB263204 mRNA. Translation: BAF80442.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14454.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae."
    Basyuni M., Oku H., Tsujimoto E., Kinjo K., Baba S., Takara K.
    FEBS J. 274:5028-5042(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Leaf.

Entry informationi

Entry nameiTARS_RHISY
AccessioniPrimary (citable) accession number: A8C981
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: November 13, 2007
Last modified: October 1, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.