A8C980 (GERS_RHISY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Germanicol synthase
Short name=RsM1
EC=5.4.99.34

Gene names

Name:

M1

Organism

Rhizophora stylosa (Bakau) (Red mangrove)

Taxonomic identifier

98588 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Malpighiales › Rhizophoraceae › Rhizophora

Protein attributes

Sequence length	759 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Multifunctional triterpene synthase producing germanicol, beta-amyrin and lupeol in the ratio 63:33:4. Ref.1
Catalytic activity	(3S)-2,3-epoxy-2,3-dihydrosqualene = germanicol. Ref.1
Sequence similarities	Belongs to the terpene cyclase/mutase family.

Ontologies

Keywords
Domain	Repeat
Molecular function	Isomerase
Gene Ontology (GO)
Biological_process	metabolic process Inferred from electronic annotation. Source: GOC
Molecular_function	intramolecular transferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 759	759	Germanicol synthase		PRO_0000412987

Sequences

	Sequence		Length	Mass (Da)
	A8C980 [UniParc]. Last modified November 13, 2007. Version 1. Checksum: 8F2939D76613A645	FASTA	759	87,523
	10 20 30 40 50 60 MWRLKIAEGG NDPYLYSTNN YVGRQIWEFD PDAGTPEERA KAEEARQNFY KNRYQVKPSG 70 80 90 100 110 120 DLLWRLQFLR EKNFKQTIPQ VRIEEGEEIT REKATTALRR AVQFFSALQA SDGHWPAENA 130 140 150 160 170 180 GPLFFLPPLV MCMCITGHLD TVFPAEHRKE ILRYIYYHQN EDGGWGLHIE GHSTMFCTAL 190 200 210 220 230 240 NYICMRILGE GPNGGQDDAC TRARKWIHDH GSVTNIPSWG KTWLSILGVY DWSGCNPMPP 250 260 270 280 290 300 EFWMLPSFLP MHPAKMWCYC RMVYMPMSYL YGKRFVGLIT PLIQQLREEL FTQPYDQINW 310 320 330 340 350 360 KKNCHQCAPE DLYYPHPFIQ DLIWDCLYIS MEPLLTRWPL NMIIRKKALE LTMKHIHYED 370 380 390 400 410 420 GSSRYITIGC VEKVLCMLAC WVEDPNGDYF KKHLARIPDY IWVAEDGMKM QSFGSQQWDT 430 440 450 460 470 480 GFAIQALLAT NLTDEIGGVL RRGHDFIKKS QVQDNPSGDF KSMYRHISKG SWTFSDQDHG 490 500 510 520 530 540 WQVSDCTAEG LKCCLLFSMM PPEIVGEHME PERLYDSVNV LLSLQSKNGG LSAWEPAGAQ 550 560 570 580 590 600 DWLELLNPTE FFADIVIEHE YVERTSSAIH ALVLFKKLYP GHRKKEIEDF IAKSVRFLES 610 620 630 640 650 660 IQTSDGTWYG NWGVCFTYGT WFALGGLAAA GKTYNSCLAM RKAVDFLLRI QKDDGGWGES 670 680 690 700 710 720 YLSCPEKKYV PLEANHSNLV HTAWAMMALV HAGQMDRDPT PLHRAAKLMI NSQLEDGDFP 730 740 750 QQEITGVFNR NCMLHYAAYR NIYPLWALAE YCRRVPLPS

References

[1]	"Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae." Basyuni M., Oku H., Tsujimoto E., Kinjo K., Baba S., Takara K. FEBS J. 274:5028-5042(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY. Tissue: Leaf.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB263203 mRNA. Translation: BAF80441.1.
3D structure databases
ProteinModelPortal	A8C980.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-14453.
Family and domain databases
InterPro	IPR001330. Prenyltrans. IPR018333. Squalene_cyclase. IPR008930. Terpenoid_cyclase/PrenylTrfase. [Graphical view]
Pfam	PF00432. Prenyltrans. 1 hit. [Graphical view]
SUPFAM	SSF48239. Terp_cyc_toroid. 2 hits.
TIGRFAMs	TIGR01787. squalene_cyclas. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GERS_RHISY

Accession

Primary (citable) accession number: A8C980

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2011
Last sequence update:	November 13, 2007
Last modified:	October 3, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program