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Protein

Germanicol synthase

Gene

M1

Organism
Rhizophora stylosa (Bakau) (Red mangrove)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Multifunctional triterpene synthase producing germanicol, beta-amyrin and lupeol in the ratio 63:33:4.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = germanicol.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14453.
BRENDAi5.4.99.34. 5362.

Names & Taxonomyi

Protein namesi
Recommended name:
Germanicol synthase (EC:5.4.99.34)
Short name:
RsM1
Gene namesi
Name:M1
OrganismiRhizophora stylosa (Bakau) (Red mangrove)
Taxonomic identifieri98588 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesRhizophoraceaeRhizophora

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Germanicol synthasePRO_0000412987Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliA8C980.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.

Sequencei

Sequence statusi: Complete.

A8C980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLKIAEGG NDPYLYSTNN YVGRQIWEFD PDAGTPEERA KAEEARQNFY
60 70 80 90 100
KNRYQVKPSG DLLWRLQFLR EKNFKQTIPQ VRIEEGEEIT REKATTALRR
110 120 130 140 150
AVQFFSALQA SDGHWPAENA GPLFFLPPLV MCMCITGHLD TVFPAEHRKE
160 170 180 190 200
ILRYIYYHQN EDGGWGLHIE GHSTMFCTAL NYICMRILGE GPNGGQDDAC
210 220 230 240 250
TRARKWIHDH GSVTNIPSWG KTWLSILGVY DWSGCNPMPP EFWMLPSFLP
260 270 280 290 300
MHPAKMWCYC RMVYMPMSYL YGKRFVGLIT PLIQQLREEL FTQPYDQINW
310 320 330 340 350
KKNCHQCAPE DLYYPHPFIQ DLIWDCLYIS MEPLLTRWPL NMIIRKKALE
360 370 380 390 400
LTMKHIHYED GSSRYITIGC VEKVLCMLAC WVEDPNGDYF KKHLARIPDY
410 420 430 440 450
IWVAEDGMKM QSFGSQQWDT GFAIQALLAT NLTDEIGGVL RRGHDFIKKS
460 470 480 490 500
QVQDNPSGDF KSMYRHISKG SWTFSDQDHG WQVSDCTAEG LKCCLLFSMM
510 520 530 540 550
PPEIVGEHME PERLYDSVNV LLSLQSKNGG LSAWEPAGAQ DWLELLNPTE
560 570 580 590 600
FFADIVIEHE YVERTSSAIH ALVLFKKLYP GHRKKEIEDF IAKSVRFLES
610 620 630 640 650
IQTSDGTWYG NWGVCFTYGT WFALGGLAAA GKTYNSCLAM RKAVDFLLRI
660 670 680 690 700
QKDDGGWGES YLSCPEKKYV PLEANHSNLV HTAWAMMALV HAGQMDRDPT
710 720 730 740 750
PLHRAAKLMI NSQLEDGDFP QQEITGVFNR NCMLHYAAYR NIYPLWALAE

YCRRVPLPS
Length:759
Mass (Da):87,523
Last modified:November 13, 2007 - v1
Checksum:i8F2939D76613A645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB263203 mRNA. Translation: BAF80441.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB263203 mRNA. Translation: BAF80441.1.

3D structure databases

ProteinModelPortaliA8C980.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14453.
BRENDAi5.4.99.34. 5362.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae."
    Basyuni M., Oku H., Tsujimoto E., Kinjo K., Baba S., Takara K.
    FEBS J. 274:5028-5042(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY.
    Tissue: Leaf.

Entry informationi

Entry nameiGERS_RHISY
AccessioniPrimary (citable) accession number: A8C980
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: November 13, 2007
Last modified: May 27, 2015
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.