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A8C8X0

- PA_I67A2

UniProt

A8C8X0 - PA_I67A2

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Protein

Polymerase acidic protein

Gene
PA
Organism
Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication By similarity.

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: InterPro

GO - Biological processi

  1. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
  2. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Polymerase acidic protein
Alternative name(s):
RNA-directed RNA polymerase subunit P2
Gene namesi
Name:PA
OrganismiInfluenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
Taxonomic identifieri382855 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Polymerase acidic proteinPRO_0000373004Add
BLAST

Post-translational modificationi

Phosphorylated on serines and threonines by host kinases, including human casein kinase II By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA By similarity.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001009. RNA-dir_pol_influenzavirus.
[Graphical view]
PfamiPF00603. Flu_PA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

Isoform PA (identifier: A8C8X0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEDFVRQCFN PMIVELAEKT MKEYGENPKI ETNKFAAICT HMEVCFMYSD    50
FHFINERGES IIVEPGDSNA LLKHRFEIIE GRDRNMAWTV VNSICNTTGV 100
GKPRFLPDLY DYKEDRFIEI GVTRREIHIY YLEKANKIKS EETHIHIFSF 150
TGEEMATKAD YTLDEESRAR IKTRLFTIRQ EMASRGLWDS FRQSERGEET 200
IEERFEITGT MRRLADQSLP PNFSSLDNFR AYVDGFEPNG YIEGKLSQMS 250
REVNARIEPF LKTTPRPLRL PCGPPCFQRS KFLLMDALKL NIEDPSHEGE 300
GIPLYDAVRC MKTFFGWKEP TIVKPHEKGI NSNYLLAWKQ VLAEIQDIED 350
EKKIPRIKNM KKTSPLKWAL GENMAPEKVD FDDCKDVSDL KQYDSDEPEF 400
RSLASWIQNE FNKACELTDS SWLELDEIGE DVAPIEHIAS MRRNYFTAEV 450
SHCRATEYIM KGVYINTALL NASCAAMDDF QLIPMISKCR TKEGRRKTNL 500
YGFIIKGRSH LRNDTDVVNF VSMEFSLTDP RLEPHKWEKY CILEIGDMVL 550
RTAIGQVARP MFLYVRTNGT SKIKMKWGME MRRCLLQSLQ QIESMIEAES 600
SVKEKDMTKE FFENKSETWP IGESPKGVEE GSIGKVCRTL LAKSVFNCLY 650
ASPQLEGFSA ESRKLLLIVQ ALRDNLEPGT FDLGGLYESI EECLINDPWV 700
LLNASWFNSF LTHALR 716
Length:716
Mass (Da):82,810
Last modified:November 13, 2007 - v1
Checksum:iDE53B9A61E876EE9
GO
Isoform PA-X (identifier: P0DJV3-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P0DJV3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:252
Mass (Da):29,453
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CY026296 Viral cRNA. Translation: ABV82591.1.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CY026296 Viral cRNA. Translation: ABV82591.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001009. RNA-dir_pol_influenzavirus.
[Graphical view ]
Pfami PF00603. Flu_PA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. The NIAID Influenza Genome Sequencing Consortium
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiPA_I67A2
AccessioniPrimary (citable) accession number: A8C8X0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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