Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Cysteine-rich with EGF-like domains 1

Gene

Creld1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cysteine-rich with EGF-like domains 1Imported
Submitted name:
I11E7 proteinImported
Gene namesi
Name:Creld1Imported
ORF Names:mCG_132966Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2152539. Creld1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei364 – 382HelicalSequence analysisAdd BLAST19
Transmembranei387 – 405HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500932928930 – 420Sequence analysisAdd BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi183 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000030284.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032422.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 193EGF-likeInterPro annotationAdd BLAST41
Domaini305 – 342EGF-likeInterPro annotationAdd BLAST38

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4260. Eukaryota.
ENOG41107X2. LUCA.
HOVERGENiHBG081344.
OMAiEPHPCHT.
OrthoDBiEOG091G09AA.

Family and domain databases

InterProiView protein in InterPro
IPR021852. DUF3456.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
PfamiView protein in Pfam
PF11938. DUF3456. 1 hit.
PF07645. EGF_CA. 2 hits.
SMARTiView protein in SMART
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00261. FU. 2 hits.
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
PS01248. EGF_LAM_1. 1 hit.

Sequencei

Sequence statusi: Complete.

A8C1T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLPPRGLV PSLLWCLSLF LSLPGPVWLQ PSPPPHPSPR AEPHPCHTCR
60 70 80 90 100
ALVDNFNKGL ERTIRDNFGG GNTAWEEEKL SKYKDSETRL VEVLEGVCSR
110 120 130 140 150
SDFECHRLLE LSEELVENWW FHRQQEAPDL FQWLCSDSLK LCCPSGTFGP
160 170 180 190 200
SCLPCPGGTE RPCGGYGQCE GEGTRGGSGH CDCQAGYGGE ACGQCGLGYF
210 220 230 240 250
EAERNSSHLV CSACFGPCAR CTGPEESHCL QCKKGWALHH LKCVDIDECG
260 270 280 290 300
TEQATCGADQ FCVNTEGSYE CRDCAKACLG CMGAGPGRCK KCSRGYQQVG
310 320 330 340 350
SKCLDVDECE TVVCPGENEK CENTEGGYRC VCAEGYRQED GICVKEQVPE
360 370 380 390 400
SAGFFAEMTE DEMVVLQQMF FGVIICALAT LAAKGDLVFT AIFIGAVAAM
410 420
TGYWLSERSD RVLEGFIKGR
Length:420
Mass (Da):45,718
Last modified:November 13, 2007 - v1
Checksum:i4066BF2D739D3179
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009020 mRNA. Translation: BAF80621.1.
CH466523 Genomic DNA. Translation: EDK99479.1.
RefSeqiNP_598691.1. NM_133930.1.
UniGeneiMm.41593.

Genome annotation databases

GeneIDi171508.
KEGGimmu:171508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009020 mRNA. Translation: BAF80621.1.
CH466523 Genomic DNA. Translation: EDK99479.1.
RefSeqiNP_598691.1. NM_133930.1.
UniGeneiMm.41593.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032422.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171508.
KEGGimmu:171508.

Organism-specific databases

CTDi78987.
MGIiMGI:2152539. Creld1.

Phylogenomic databases

eggNOGiKOG4260. Eukaryota.
ENOG41107X2. LUCA.
HOVERGENiHBG081344.
OMAiEPHPCHT.
OrthoDBiEOG091G09AA.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030284.

Family and domain databases

InterProiView protein in InterPro
IPR021852. DUF3456.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
PfamiView protein in Pfam
PF11938. DUF3456. 1 hit.
PF07645. EGF_CA. 2 hits.
SMARTiView protein in SMART
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00261. FU. 2 hits.
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
PS01248. EGF_LAM_1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA8C1T7_MOUSE
AccessioniPrimary (citable) accession number: A8C1T7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2007
Last sequence update: November 13, 2007
Last modified: February 15, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.