ID   A8B2K2_GIAIC            Unreviewed;       145 AA.
AC   A8B2K2;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=Ribose 5-phosphate isomerase {ECO:0000313|EMBL:EDO82317.1};
DE            EC=5.3.1.6 {ECO:0000313|EMBL:EDO82317.1};
GN   ORFNames=GL50803_0027614 {ECO:0000313|EMBL:KAE8302995.1},
GN   GL50803_27614 {ECO:0000313|EMBL:EDO82317.1};
OS   Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO82317.1};
RN   [1] {ECO:0000313|EMBL:EDO82317.1, ECO:0000313|Proteomes:UP000001548}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC   and WB C6 {ECO:0000313|EMBL:EDO82317.1};
RX   PubMed=17901334; DOI=10.1126/science.1143837;
RA   Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA   Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA   Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA   Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA   Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA   Svard S.G., Sogin M.L.;
RT   "Genomic minimalism in the early diverging intestinal parasite Giardia
RT   lamblia.";
RL   Science 317:1921-1926(2007).
RN   [2] {ECO:0007829|PDB:3S5P}
RP   X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
RG   Seattle Structural Genomics Center for Infectious Disease (SSGCID);
RA   Edwards T.E., Abendroth J.;
RT   "Crystal structure of ribose-5-phosphate isomerase B RpiB from Giardia
RT   lamblia.";
RL   Submitted (MAY-2011) to the PDB data bank.
RN   [3] {ECO:0000313|EMBL:KAE8302995.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=WB C6 {ECO:0000313|EMBL:KAE8302995.1};
RA   Xu F., Jex A., Svard S.G.;
RT   "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDO82317.1}.
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DR   EMBL; AACB02000001; EDO82317.1; -; Genomic_DNA.
DR   EMBL; AACB03000003; KAE8302995.1; -; Genomic_DNA.
DR   RefSeq; XP_001709991.1; XM_001709939.1.
DR   PDB; 3S5P; X-ray; 2.30 A; A/B=1-145.
DR   PDBsum; 3S5P; -.
DR   AlphaFoldDB; A8B2K2; -.
DR   SMR; A8B2K2; -.
DR   STRING; 184922.A8B2K2; -.
DR   EnsemblProtists; EDO82317; EDO82317; GL50803_27614.
DR   GeneID; 5702915; -.
DR   KEGG; gla:GL50803_0027614; -.
DR   VEuPathDB; GiardiaDB:GL50803_27614; -.
DR   HOGENOM; CLU_091396_4_1_1; -.
DR   InParanoid; A8B2K2; -.
DR   OMA; YPPFCLR; -.
DR   Proteomes; UP000001548; Chromosome 3.
DR   GO; GO:0016853; F:isomerase activity; IBA:GO_Central.
DR   GO; GO:0004751; F:ribose-5-phosphate isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1400.10; Sugar-phosphate isomerase, RpiB/LacA/LacB; 1.
DR   InterPro; IPR004785; RpiB.
DR   InterPro; IPR003500; RpiB_LacA_LacB.
DR   InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR   NCBIfam; TIGR01120; rpiB; 1.
DR   NCBIfam; TIGR00689; rpiB_lacA_lacB; 1.
DR   PANTHER; PTHR30345:SF0; DNA DAMAGE-REPAIR_TOLERATION PROTEIN DRT102; 1.
DR   PANTHER; PTHR30345; RIBOSE-5-PHOSPHATE ISOMERASE B; 1.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   SUPFAM; SSF89623; Ribose/Galactose isomerase RpiB/AlsB; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3S5P};
KW   Isomerase {ECO:0000313|EMBL:EDO82317.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001548}.
SQ   SEQUENCE   145 AA;  15349 MW;  D629E3DBD494E116 CRC64;
     MKVAFASDHG GRDLRMFLQQ RASAHGYEVM DLGTESDASV DYPDFAKIGC EAVTSGRADC
     CILVCGTGIG ISIAANKMKG IRCALCSTEY DAEMARKHNN ANALALGGRT TGPEVAASIL
     SRFLSTNFEG GRHAARIAKI SAMEE
//