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A8AZQ5 (A8AZQ5_STRGC) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HAMAP MF_00108
EC=2.7.7.60 HAMAP MF_00108
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase HAMAP MF_00108
MEP cytidylyltransferase HAMAP MF_00108
Gene names
Name:ispD HAMAP MF_00108
Ordered Locus Names:SGO_2017
OrganismStreptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]
Taxonomic identifier29390 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108 SAAS SAAS018294

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108 SAAS SAAS018294

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108 SAAS SAAS018294

Sequence similarities

Belongs to the IspD family. HAMAP MF_00108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Site151Transition state stabilizer By similarity HAMAP MF_00108
Site231Transition state stabilizer By similarity HAMAP MF_00108
Site1591Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108
Site2161Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108

Sequences

Sequence LengthMass (Da)Tools
A8AZQ5 [UniParc].

Last modified October 23, 2007. Version 1.
Checksum: CCE7520DE6F3704A

FASTA24026,950
        10         20         30         40         50         60 
MTVSALIFAG GTGKRMNTKT LPKQFLELHG KPIIIHTIEH FEAHSEIKDI VVVCVDDWLD 

        70         80         90        100        110        120 
YCKDLLAKFN IKKVSQVVPG GETGQMSIFN GLETLREKYQ GNDDYVLIHD GVRPLIDEEI 

       130        140        150        160        170        180 
ISKNIESVKK YGTAITVKPV IETVVQVDEE DIINNVIERS TCQTAVAPQS FVLSEIYSLH 

       190        200        210        220        230        240 
MRAQAEKLFD MTDSATLARY YGLSLHTVMG GSENIKITTP SDFYIFRAIY EARENAQIFG

« Hide

References

[1]"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide."
Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R.
J. Bacteriol. 189:7799-7807(2007) [PubMed: 17720781] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Challis EMBL ABV10518.1.
[2]Gill S.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Challis EMBL ABV10518.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000725 Genomic DNA. Translation: ABV10518.1.
RefSeqYP_001451265.1. NC_009785.1.

3D structure databases

ProteinModelPortalA8AZQ5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000011666; EBSTRP00000011223; EBSTRG00000011666.
GeneID5599137.
GenomeReviewsGene locus SGO_2017 in contig CP000725_GR.
KEGGsgo:SGO_2017.
PATRIC19661982. VBIStrGor124371_1967.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000027822.
HOGENOMHBG672839.
OMAYIFRAIY.
ProtClustDBCLSK904510.

Enzyme and pathway databases

BioCycSGOR29390:SGO_2017-MONOMER.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00453. IspD. 1 hit.
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA8AZQ5_STRGC
AccessionPrimary (citable) accession number: A8AZQ5
Entry history
Integrated into UniProtKB/TrEMBL: October 23, 2007
Last sequence update: October 23, 2007
Last modified: January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info