A8AZ67 (A8AZ67_STRGC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase 2 HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase 2 HAMAP MF_01543

Gene names

Name:	fhs-2 EMBL ABV09965.1
Synonyms:	fhs2 HAMAP MF_01543
Ordered Locus Names:	SGO_1808

Organism

Streptococcus gordonii (strain Challis / ATCC 35105 / CH1 / DL1 / V288) [Complete proteome] [HAMAP]

Taxonomic identifier

29390 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543
Ligand	ATP-binding HAMAP MF_01543 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 EMBL ABV09965.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	66 – 73	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	A8AZ67 [UniParc]. Last modified October 23, 2007. Version 1. Checksum: C7D8A483ADAA648D	FASTA	557	59,053
	10 20 30 40 50 60 MVLSDIEIAN SVQMKPIKEV AEKLGIAEDA LSLYGNYKAK ISAGQLEALK DKPDGKLILV 70 80 90 100 110 120 TAISPTPAGE GKTTTSVGLV DALAAIGKKA VIALREPSLG PVFGIKGGAA GGGHAQVVPM 130 140 150 160 170 180 EDINLHFTGD FHAIGVANNL LAALIDNHIH HGNALGIDSR RITWKRAVDM NDRQLRHIVD 190 200 210 220 230 240 GLQGKVNGVP REDGFDITVA SEVMAILCLS ENITDLKNRL EKIIIGYSFE GKPITAKDLK 250 260 270 280 290 300 AGGAMAAVLK DAIHPNLVQT LEHTPALIHG GPFANIAHGC NSVLATKLAL KYADYAVTEA 310 320 330 340 350 360 GFGADLGAEK FIDIKCRTSG LRPSAVVLVA TIRALKMHGG VAKSDLAEEN VQAVVDGLPN 370 380 390 400 410 420 LEKHLENIQD VYGLPAVVAI NKFPLDTEAE LQAVYDACQK RGVDVVISDV WANGGAGGKE 430 440 450 460 470 480 LAEKVVKLAE GDNHFQFVYN EEDSIETKLN KIVTKVYGGK GVRLTPAAKR ELKQLEELGF 490 500 510 520 530 540 SNYPICMAKT QYSFSDDAKK LGAPKDFVVT ISQLKVSAGA GFIVALTGAI MTMPGLPKVP 550 ASEKIDVDKD GNISGLF

References

[1]	"Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide." Vickerman M.M., Iobst S., Jesionowski A.M., Gill S.R. J. Bacteriol. 189:7799-7807(2007) [PubMed: 17720781] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Challis EMBL ABV09965.1.
[2]	Gill S. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Challis EMBL ABV09965.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000725 Genomic DNA. Translation: ABV09965.1.
RefSeq	YP_001451077.1. NC_009785.1.
3D structure databases
ProteinModelPortal	A8AZ67.
SMR	A8AZ67. Positions 5-555.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000010542; EBSTRP00000010099; EBSTRG00000010542.
GeneID	5598466.
GenomeReviews	Gene locus SGO_1808 in contig CP000725_GR.
KEGG	sgo:SGO_1808.
PATRIC	19661564. VBIStrGor124371_1776.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027107.
HOGENOM	HBG677721.
OMA	TDFTVTI.
ProtClustDB	PRK13505.
Enzyme and pathway databases
BioCyc	SGOR29390:SGO_1808-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A8AZ67_STRGC

Accession

Primary (citable) accession number: A8AZ67

Entry history

Integrated into UniProtKB/TrEMBL:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)