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Protein

Imidazolonepropionase

Gene

hutI

Organism
Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+.UniRule annotation

Cofactori

Zn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 1 zinc or iron ion per subunit.UniRule annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 3 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (hutH)
  2. Urocanate hydratase (hutU)
  3. Imidazolonepropionase (hutI)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Zinc or ironUniRule annotation1
Metal bindingi83Zinc or ironUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Binding sitei103SubstrateUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Binding sitei186SubstrateUniRule annotation1
Metal bindingi251Zinc or ironUniRule annotation1
Binding sitei254SubstrateUniRule annotation1
Metal bindingi326Zinc or ironUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Histidine metabolism

Keywords - Ligandi

Iron, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00379; UER00551.

Protein family/group databases

MEROPSiM38.980.

Names & Taxonomyi

Protein namesi
Recommended name:
ImidazolonepropionaseUniRule annotation (EC:3.5.2.7UniRule annotation)
Alternative name(s):
Imidazolone-5-propionate hydrolaseUniRule annotation
Gene namesi
Name:hutIUniRule annotation
Ordered Locus Names:SGO_1804
OrganismiStreptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)
Taxonomic identifieri467705 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001131 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000798351 – 421ImidazolonepropionaseAdd BLAST421

Interactioni

Protein-protein interaction databases

STRINGi467705.SGO_1804.

Structurei

3D structure databases

ProteinModelPortaliA8AZ63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HutI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI2. Bacteria.
COG1228. LUCA.
HOGENOMiHOG000218460.
KOiK01468.
OMAiDHCTHLT.
OrthoDBiPOG091H0EIK.

Family and domain databases

CDDicd01296. Imidazolone-5PH. 1 hit.
Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_00372. HutI. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR005920. HutI.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01224. hutI. 1 hit.

Sequencei

Sequence statusi: Complete.

A8AZ63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTADLLLTHF NQVFCPNDLG HPLFGAEMKE ARVLEDGYIA VKDGKILAVG
60 70 80 90 100
SGEPDASLIG PDTKIQSYEG KIATPGLIDC HTHLVYGGSR EHEFAKKLAG
110 120 130 140 150
VPYLEILAQG GGILSTVRAT REASFENLYD KSKKLLDYML LHGVTTVEAK
160 170 180 190 200
SGYGLNWETE KRQLDVVGAL DRDHEIDLVS TFMAAHAVPP EYKGRSQEYL
210 220 230 240 250
ELIVEEMLPR VKEENLAEFC DIFCEKGVFT ADESRYLLSK AKEMGFKLRI
260 270 280 290 300
HADEIESIGG VDVAAELGAT SAEHLMMATD EGIRKMAEAK VIGNLLPATT
310 320 330 340 350
FSLMEDTYAP ARKMLEAGMA ITLTTDSNPG SCPTANLQFV MQLGCFMMRL
360 370 380 390 400
TPVEVLNAVT INAAYSVNRQ DKIGSFDTGK QADITILDAK NIDYPLYFFA
410 420
TNLTHQVYKA GKLVVDQGRI V
Length:421
Mass (Da):46,218
Last modified:October 23, 2007 - v1
Checksum:i5DA3147B4C493682
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA. Translation: ABV09769.1.
RefSeqiWP_012130839.1. NC_009785.1.

Genome annotation databases

EnsemblBacteriaiABV09769; ABV09769; SGO_1804.
GeneIDi25053200.
KEGGisgo:SGO_1804.
PATRICi19661556. VBIStrGor124371_1772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000725 Genomic DNA. Translation: ABV09769.1.
RefSeqiWP_012130839.1. NC_009785.1.

3D structure databases

ProteinModelPortaliA8AZ63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi467705.SGO_1804.

Protein family/group databases

MEROPSiM38.980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABV09769; ABV09769; SGO_1804.
GeneIDi25053200.
KEGGisgo:SGO_1804.
PATRICi19661556. VBIStrGor124371_1772.

Phylogenomic databases

eggNOGiENOG4105CI2. Bacteria.
COG1228. LUCA.
HOGENOMiHOG000218460.
KOiK01468.
OMAiDHCTHLT.
OrthoDBiPOG091H0EIK.

Enzyme and pathway databases

UniPathwayiUPA00379; UER00551.

Family and domain databases

CDDicd01296. Imidazolone-5PH. 1 hit.
Gene3Di2.30.40.10. 2 hits.
HAMAPiMF_00372. HutI. 1 hit.
InterProiIPR006680. Amidohydro-rel.
IPR005920. HutI.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR01224. hutI. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHUTI_STRGC
AccessioniPrimary (citable) accession number: A8AZ63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 23, 2007
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.